[{"data":1,"prerenderedAt":172},["ShallowReactive",2],{"drug-avanafil":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":21,"regimens":52,"contraindications":79,"warnings":89,"renal":90,"monitoring":91,"interactions":92,"review":93,"examples":96,"atc":101,"iran":103,"links":110,"populations":125,"usApproval":167},"avanafil",1,{"fa":7,"en":8},"آوانافیل","Avanafil","genitourinary-sex-hormones",{"fa":11,"en":12},"مهارکننده PDE5","PDE5 inhibitor",[14],{"name":15,"market":16},"Stendra","US",[18,19,7,20],"stendra","استندرا","spedra",[22,36,44],{"id":23,"form":24,"route":25,"label":26,"concentration":27,"markets":31,"refs":32},"tab-50","tablet","oral","50 mg tablet",{"amount":28,"unit":29,"perUnit":24,"scored":30},50,"mg",false,[16],[33],{"source":34,"section":35},"fda-avanafil","3",{"id":37,"form":24,"route":25,"label":38,"concentration":39,"markets":41,"refs":42},"tab-100","100 mg tablet",{"amount":40,"unit":29,"perUnit":24,"scored":30},100,[16],[43],{"source":34,"section":35},{"id":45,"form":24,"route":25,"label":46,"concentration":47,"markets":49,"refs":50},"tab-200","200 mg tablet",{"amount":48,"unit":29,"perUnit":24,"scored":30},200,[16],[51],{"source":34,"section":35},[53],{"id":54,"disease":55,"label":56,"population":59,"type":63,"unit":29,"dose":64,"refs":65,"limits":68,"notes":72},"ed","erectile-dysfunction",{"fa":57,"en":58},"اختلال نعوذ — ۱۰۰ mg حدود ۱۵ دقیقه پیش از فعالیت جنسی","Erectile dysfunction — 100 mg about 15 min before sexual activity",{"minAge":60},{"value":61,"unit":62},18,"year","fixed",{"perDose":40,"dosesPerDay":5},[66],{"source":34,"section":67},"2.1",{"maxPerDay":48,"refs":69},[70],{"source":34,"section":71},"2",[73],{"text":74,"refs":77},{"fa":75,"en":76},"بسته به اثر ۵۰ تا ۲۰۰ mg؛ بیش از یک بار در روز نه.","Adjust 50–200 mg; no more than once a day.",[78],{"source":34,"section":71},[80],{"id":81,"severity":82,"text":83,"refs":86},"nitrates","block",{"fa":84,"en":85},"مصرف هم‌زمان با هر نوع نیترات یا ریوسیگوات\u002Fوریسیگوات.","Use with any organic nitrate or riociguat\u002Fvericiguat.",[87],{"source":34,"section":88},"4",[],[],[],[],{"status":94,"reviewer":95,"date":95},"unverified",null,[97],{"regimen":54,"formulation":37,"input":98,"expect":100},{"ageYears":28,"weightKg":99},80,{"perDose":40,"tabletsPerDoseRounded":5},[102],"G04BE10",{"status":104,"refs":105},"not-found",[106],{"source":107,"section":108,"url":109},"darooyab-generic","search","https:\u002F\u002Fwww.darooyab.ir\u002FSearch?q=avanafil",[111,115,119,122],{"kind":112,"url":113,"label":114},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=202276","NDA202276",{"kind":116,"url":117,"label":118},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=fa7d93e3-b69b-4e02-8146-89760cd8e9d6","FDA Stendra",{"kind":120,"url":121,"label":8},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa614010.html",{"kind":123,"url":124,"label":102},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=G04BE10",{"pregnancy":126,"lactation":135,"pediatric":142,"geriatric":151,"reproductive":159},{"level":127,"text":128,"quote":131,"refs":132},"caution",{"fa":129,"en":130},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","Risk Summary STENDRA is not indicated for use in females.",[133],{"source":34,"section":134},"8.1",{"level":127,"text":136,"quote":131,"refs":139},{"fa":137,"en":138},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.",[140],{"source":34,"section":141},"8.2",{"level":143,"text":144,"quote":147,"refs":148},"not-established",{"fa":145,"en":146},"برچسب: ایمنی و اثربخشی در کودکان ثابت نشده است.","Label: safety and effectiveness in children have not been established.","STENDRA is not indicated for use in pediatric patients.",[149],{"source":34,"section":150},"8.4",{"level":127,"text":152,"quote":155,"refs":156},{"fa":153,"en":154},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","However, a greater sensitivity to medication in some older individuals should be considered [ s ee Clinical Pharmacology (12.3) ] .",[157],{"source":34,"section":158},"8.5",{"level":127,"text":160,"quote":163,"refs":164},{"fa":161,"en":162},"برچسب نکته‌ای درباره بارداری، پیشگیری یا باروری زنان و مردان دارد.","Label has advice on pregnancy testing, contraception or fertility for females and males.","Infertility There have been no studies evaluating the effect of STENDRA on fertility in men [ see Clinical Pharmacology (12.2) ] Based on studies in animals, decreased fertility, abnormal sperm motility and morphology, and altered estrous cycles were observed in rats.",[165],{"source":34,"section":166},"8.3",{"kind":168,"refs":169,"id":114},"NDA",[170],{"source":34,"section":171},"SPL approval \u002F marketing category",1792091052625]