[{"data":1,"prerenderedAt":198},["ShallowReactive",2],{"drug-amikacin":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":21,"regimens":35,"contraindications":87,"warnings":97,"renal":107,"monitoring":108,"interactions":109,"review":110,"examples":113,"atc":127,"iran":129,"usApproval":145,"links":151,"populations":172},"amikacin",1,{"fa":7,"en":8},"آمیکاسین (تزریقی)","Amikacin (injection)","anti-infectives",{"fa":11,"en":12},"آمینوگلیکوزید","Aminoglycoside",[14],{"name":15,"market":16},"Amikin","US",[18,19,20],"amikin","آمیکاسین","آمپول آمیکاسین",[22],{"id":23,"form":24,"route":25,"label":26,"concentration":27,"markets":30,"refs":31},"vial-250","injection","im","250 mg\u002FmL (500 mg\u002F2 mL; 1 g\u002F4 mL) vial",{"amount":28,"unit":29,"perVolumeMl":5},250,"mg",[16],[32],{"source":33,"section":34},"fda-amikacin","How Supplied",[36,66],{"id":37,"disease":38,"label":39,"population":42,"type":45,"unit":29,"dose":46,"refs":49,"limits":52,"durationDays":56,"notes":59},"std","sepsis",{"fa":40,"en":41},"بزرگسال، کودک و شیرخوار بزرگ‌تر با کلیه سالم — ۱۵ mg\u002Fkg\u002Fروز در ۲ تا ۳ دوز","Adults, children and older infants with normal renal function — 15 mg\u002Fkg\u002Fday in 2–3 doses",{"minAge":43},{"value":5,"unit":44},"month","weightBased",{"perKgPerDay":47,"dividedDoses":48},15,2,[50],{"source":33,"section":51},"Dosage and Administration",{"maxPerDay":53,"refs":54},1500,[55],{"source":33,"section":51},{"min":57,"max":58},7,10,[60],{"text":61,"refs":64},{"fa":62,"en":63},"یعنی ۷٫۵ mg\u002Fkg هر ۱۲ ساعت یا ۵ mg\u002Fkg هر ۸ ساعت؛ حداکثر ۱٫۵ g در روز. سطح سرمی، کلیه، شنوایی و تعادل پایش شود.","i.e. 7.5 mg\u002Fkg every 12 h or 5 mg\u002Fkg every 8 h; max 1.5 g\u002Fday. Monitor serum levels, renal, auditory and vestibular function.",[65],{"source":33,"section":51},{"id":67,"disease":38,"label":68,"population":71,"type":45,"unit":29,"dose":73,"refs":76,"notes":78},"neo",{"fa":69,"en":70},"نوزاد — بارگذاری ۱۰ mg\u002Fkg سپس ۷٫۵ mg\u002Fkg هر ۱۲ ساعت","Newborn — load 10 mg\u002Fkg then 7.5 mg\u002Fkg every 12 h",{"maxAge":72},{"value":5,"unit":44},{"perKgPerDose":74,"intervalHours":75},7.5,12,[77],{"source":33,"section":51},[79],{"text":80,"refs":83},{"fa":81,"en":82},"دوز اول ۱۰ mg\u002Fkg. در نارس و نوزاد به‌علت نارسی کلیه با احتیاط.","First dose 10 mg\u002Fkg. Caution in premature and newborn infants (renal immaturity).",[84,85],{"source":33,"section":51},{"source":33,"section":86},"Pediatric Use",[88],{"id":89,"severity":90,"text":91,"refs":94},"hyper","block",{"fa":92,"en":93},"حساسیت به آمیکاسین یا سایر آمینوگلیکوزیدها.","Hypersensitivity to amikacin or other aminoglycosides.",[95],{"source":33,"section":96},"Contraindications",[98],{"text":99,"refs":102},{"fa":100,"en":101},"هشدار جعبه‌ای: سمیت گوش، کلیه و عصبی‌عضلانی؛ آسیب جنین در بارداری.","Boxed warning: oto-, nephro- and neuromuscular toxicity; fetal harm in pregnancy.",[103,105],{"source":33,"section":104},"Boxed Warning",{"source":33,"section":106},"Warnings",[],[],[],{"status":111,"reviewer":112,"date":112},"unverified",null,[114,121],{"regimen":37,"formulation":23,"input":115,"expect":118},{"ageYears":116,"weightKg":117},40,70,{"perDose":119,"mlPerDose":120},525,2.1,{"regimen":67,"formulation":23,"input":122,"expect":124},{"ageDays":58,"weightKg":123},3.5,{"perDose":125,"mlPerDose":126},26.25,0.11,[128],"J01GB06",{"status":130,"forms":131,"refs":140},"registered",[132,136],{"code":133,"en":134,"fa":135},"00053","AMIKACIN SULFATE 100MG\u002F2ML AMP","آمپول آمیکاسین سولفات ۱۰۰ میلی‌گرم \u002F ۲ میلی‌لیتر",{"code":137,"en":138,"fa":139},"00054","AMIKACIN SULFATE 500MG\u002F2ML AMP","آمپول آمیکاسین سولفات ۵۰۰ میلی‌گرم \u002F ۲ میلی‌لیتر",[141],{"source":142,"section":143,"url":144},"darooyab-generic","G-273\u002FAmikacin","https:\u002F\u002Fwww.darooyab.ir\u002FG-273\u002FAmikacin",{"kind":146,"refs":147,"id":150},"ANDA",[148],{"source":33,"section":149},"SPL approval \u002F marketing category","ANDA203323",[152,155,159,163,166,169],{"kind":153,"url":154,"label":150},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=203323",{"kind":156,"url":157,"label":158},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=f260ff2a-76a0-4672-9516-91c344b67890","FDA Amikacin inj.",{"kind":160,"url":161,"label":162},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa682661.html","Amikacin Injection",{"kind":160,"url":164,"label":165},"https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa623020.html","Amikacin Oral Inhalation",{"kind":167,"url":168,"label":128},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=J01GB06",{"kind":170,"url":144,"label":171},"darooyab","Amikacin",{"pregnancy":173,"lactation":182,"pediatric":191},{"level":174,"text":175,"quote":178,"refs":179},"caution",{"fa":176,"en":177},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","Teratogenic Effects (See WARNINGS section.)",[180],{"source":33,"section":181},"Pregnancy",{"level":183,"text":184,"quote":187,"refs":188},"avoid",{"fa":185,"en":186},"برچسب: شیردهی توصیه نمی‌شود یا باید بین دارو و شیردهی یکی انتخاب شود.","Label: breastfeeding not recommended, or choose between the drug and breastfeeding.","Because many drugs are excreted in human milk and because of the potential for serious adverse reactions in nursing infants from amikacin, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.",[189],{"source":33,"section":190},"Nursing Mothers",{"level":174,"text":192,"quote":195,"refs":196},{"fa":193,"en":194},"برچسب برای کودکان شرط، محدودیت سنی یا نکته دارد؛ جمله برچسب در زیر آمده است.","The label has conditions, age limits or notes for children; the label sentence is quoted below.","Aminoglycosides should be used with caution in premature and neonatal infants because of the renal immaturity of these patients and the resulting prolongation of serum half-life of these drugs.",[197],{"source":33,"section":86},1792100091645]