[{"data":1,"prerenderedAt":182},["ShallowReactive",2],{"drug-adenosine":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":20,"regimens":34,"contraindications":82,"warnings":92,"renal":93,"monitoring":94,"interactions":95,"review":96,"examples":99,"atc":110,"iran":112,"links":136,"populations":151,"usApproval":177},"adenosine",1,{"fa":7,"en":8},"آدنوزین (تزریقی)","Adenosine (injection)","cardiovascular",{"fa":11,"en":12},"ضدآریتمی","Antiarrhythmic",[14],{"name":15,"market":16},"Adenocard","US",[18,19,4],"adenocard","آدنوزین",[21],{"id":22,"form":23,"route":24,"label":25,"concentration":26,"markets":29,"refs":30},"vial-3","injection","iv","3 mg\u002FmL (6 mg\u002F2 mL, 12 mg\u002F4 mL) vial",{"amount":27,"unit":28,"perVolumeMl":5},3,"mg",[16],[31],{"source":32,"section":33},"fda-adenosine","How Supplied",[35,57],{"id":36,"disease":37,"label":38,"population":41,"type":43,"unit":28,"dose":44,"refs":46,"durationDays":49,"notes":50},"adult","svt",{"fa":39,"en":40},"PSVT — بزرگسال و کودک ۵۰ kg به بالا: ۶ mg بولوس سریع، در صورت نیاز ۱۲ mg","PSVT — adults and children ≥50 kg: 6 mg rapid bolus, then 12 mg if needed",{"minWeightKg":42},50,"fixed",{"perDose":45,"dosesPerDay":5},6,[47],{"source":32,"section":48},"Dosage and Administration",{"min":5,"max":5},[51],{"text":52,"refs":55},{"fa":53,"en":54},"بولوس سریع در ۱ تا ۲ ثانیه و فوراً فلاش سالین. اگر ظرف ۱ تا ۲ دقیقه برنگشت: ۱۲ mg؛ همین ۱۲ mg را می‌توان یک بار دیگر تکرار کرد. دوز بالای ۱۲ mg توصیه نمی‌شود.","Rapid bolus over 1–2 s followed by a rapid saline flush. If no conversion within 1–2 min: 12 mg; the 12 mg dose may be repeated once. Doses over 12 mg not recommended.",[56],{"source":32,"section":48},{"id":58,"disease":37,"label":59,"population":62,"type":64,"unit":28,"dose":65,"refs":68,"limits":70,"durationDays":74,"notes":75},"child",{"fa":60,"en":61},"PSVT — کودک زیر ۵۰ kg: ۰٫۰۵ تا ۰٫۱ mg\u002Fkg بولوس سریع","PSVT — child \u003C50 kg: 0.05–0.1 mg\u002Fkg rapid bolus",{"maxWeightKg":63},49.99,"weightBased",{"perKgPerDay":66,"perKgPerDayMax":67,"dividedDoses":5},0.05,0.1,[69],{"source":32,"section":48},{"maxPerDose":71,"refs":72},12,[73],{"source":32,"section":48},{"min":5,"max":5},[76],{"text":77,"refs":80},{"fa":78,"en":79},"اگر ظرف ۱ تا ۲ دقیقه برنگشت، هر بار ۰٫۰۵ تا ۰٫۱ mg\u002Fkg بیشتر تا حداکثر یک دوز ۰٫۳ mg\u002Fkg (و نه بیش از ۱۲ mg). هر دوز با فلاش سالین.","If no conversion in 1–2 min, increase each bolus by 0.05–0.1 mg\u002Fkg up to a maximum single dose of 0.3 mg\u002Fkg (not over 12 mg). Flush after each dose.",[81],{"source":32,"section":48},[83],{"id":84,"severity":85,"text":86,"refs":89},"ci","block",{"fa":87,"en":88},"بلوک AV درجه ۲ یا ۳ یا بیماری گره سینوسی (بدون پیس‌میکر فعال)؛ حساسیت به آدنوزین.","Second- or third-degree AV block or sinus node disease (without a functioning pacemaker); hypersensitivity to adenosine.",[90],{"source":32,"section":91},"Contraindications",[],[],[],[],{"status":97,"reviewer":98,"date":98},"unverified",null,[100,106],{"regimen":36,"formulation":22,"input":101,"expect":104},{"ageYears":102,"weightKg":103},40,70,{"perDose":45,"mlPerDose":105},2,{"regimen":58,"formulation":22,"input":107,"expect":109},{"ageYears":45,"weightKg":108},20,{"perDose":5,"upperPerDose":105},[111],"C01EB10",{"status":113,"forms":114,"refs":131},"registered",[115,119,123,127],{"code":116,"en":117,"fa":118},"01836","ADENOSINE 3MG\u002FML (2ML) INJ","فرآورده تزریقی آدنوزین ۳ میلی‌گرم \u002F میلی‌لیتر، ۲ میلی‌لیتر",{"code":120,"en":121,"fa":122},"16827","ADENOSINE 5MG\u002F2ML INJ","فرآورده تزریقی آدنوزین ۵ میلی‌گرم \u002F ۲ میلی‌لیتر",{"code":124,"en":125,"fa":126},"52364","ADENOSINE INJECTION PARENTERAL 3 mg\u002F1mL 1 mL","فرآورده تزریقی آدنوزین ۳ میلی‌گرم \u002F ۱ میلی‌لیتر ۱ میلی‌لیتر",{"code":128,"en":129,"fa":130},"52365","ADENOSINE INJECTION PARENTERAL 3 mg\u002F1mL 4 mL","فرآورده تزریقی آدنوزین ۳ میلی‌گرم \u002F ۱ میلی‌لیتر ۴ میلی‌لیتر",[132],{"source":133,"section":134,"url":135},"darooyab-generic","G-1511\u002FAdenosine","https:\u002F\u002Fwww.darooyab.ir\u002FG-1511\u002FAdenosine",[137,141,145,148],{"kind":138,"url":139,"label":140},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=206778","ANDA206778",{"kind":142,"url":143,"label":144},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=546642f2-662f-46cf-9d82-5bb3bdcc7677","FDA Adenosine inj.",{"kind":146,"url":147,"label":111},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=C01EB10",{"kind":149,"url":135,"label":150},"darooyab","Adenosine",{"pregnancy":152,"pediatric":161,"geriatric":169},{"level":153,"text":154,"quote":157,"refs":158},"caution",{"fa":155,"en":156},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","Teratogenic Effects: Pregnancy Category C: Animal reproduction studies have not been conducted with adenosine; nor have studies been performed in pregnant women.",[159],{"source":32,"section":160},"Pregnancy",{"level":153,"text":162,"quote":165,"refs":166},{"fa":163,"en":164},"برچسب برای کودکان شرط، محدودیت سنی یا نکته دارد؛ جمله برچسب در زیر آمده است.","The label has conditions, age limits or notes for children; the label sentence is quoted below.","No controlled studies have been conducted in pediatric patients to establish the safety and efficacy of adenosine injection for the conversion of paroxysmal supraventricular tachycardia (PSVT).",[167],{"source":32,"section":168},"Pediatric Use",{"level":153,"text":170,"quote":173,"refs":174},{"fa":171,"en":172},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","In general, adenosine injection in geriatric patients should be used with caution since this population may have a diminished cardiac function, nodal dysfunction, concomitant diseases or drug therapy that may alter hemodynamic function and produce severe bradycardia or AV block.",[175],{"source":32,"section":176},"Geriatric Use",{"kind":178,"refs":179,"id":140},"ANDA",[180],{"source":32,"section":181},"SPL approval \u002F marketing category",1792108411748]