[{"data":1,"prerenderedAt":272},["ShallowReactive",2],{"drug-vancomycin":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":21,"regimens":57,"contraindications":136,"warnings":146,"renal":154,"monitoring":155,"interactions":156,"review":157,"examples":160,"atc":176,"iran":179,"usApproval":207,"links":213,"populations":237},"vancomycin",1,{"fa":7,"en":8},"ونکومایسین","Vancomycin","anti-infectives",{"fa":11,"en":12},"گلیکوپپتید","Glycopeptide antibiotic",[14],{"name":15,"market":16},"Vancocin","US",[18,19,7,20],"vancocin","ونکوسین","وانکومایسین",[22,36,49],{"id":23,"form":24,"route":25,"label":26,"concentration":27,"markets":31,"refs":32},"vial-1g","powder-for-injection","iv","1 g vial for IV infusion (reconstitute per label)",{"amount":28,"unit":29,"perUnit":30},1000,"mg","vial",[16],[33],{"source":34,"section":35},"fda-vancoinj","How Supplied",{"id":37,"form":38,"route":39,"label":40,"concentration":41,"markets":44,"refs":45},"cap-125","capsule","oral","125 mg capsule (oral)",{"amount":42,"unit":29,"perUnit":38,"scored":43},125,false,[16],[46],{"source":47,"section":48},"fda-vancooral","3",{"id":50,"form":38,"route":39,"label":51,"concentration":52,"markets":54,"refs":55},"cap-250","250 mg capsule (oral)",{"amount":53,"unit":29,"perUnit":38,"scored":43},250,[16],[56],{"source":47,"section":48},[58,77,97,121],{"id":59,"disease":60,"label":61,"population":64,"type":68,"unit":29,"dose":69,"refs":71,"durationDays":74,"allowedFormulations":76},"cdiff-adult","c-diff",{"fa":62,"en":63},"اسهال C. difficile — بزرگسال: ۱۲۵ mg خوراکی چهار بار در روز، ۱۰ روز","C. difficile diarrhoea — adult: 125 mg orally four times daily, 10 days",{"minAge":65},{"value":66,"unit":67},18,"year","fixed",{"perDose":42,"dosesPerDay":70},4,[72],{"source":47,"section":73},"2.1",{"min":75,"max":75},10,[37,50],{"id":78,"disease":60,"label":79,"population":82,"type":84,"unit":29,"dose":85,"refs":87,"limits":90,"durationDays":94,"allowedFormulations":96},"cdiff-child",{"fa":80,"en":81},"اسهال C. difficile — کودک: ۴۰ mg\u002Fkg\u002Fروز خوراکی در ۳ تا ۴ دوز، ۷ تا ۱۰ روز","C. difficile diarrhoea — child: 40 mg\u002Fkg\u002Fday orally in 3–4 doses, 7–10 days",{"maxAge":83},{"value":66,"unit":67},"weightBased",{"perKgPerDay":86,"dividedDoses":70},40,[88],{"source":47,"section":89},"2.2",{"maxPerDay":91,"refs":92},2000,[93],{"source":47,"section":89},{"min":95,"max":75},7,[37,50],{"id":98,"disease":99,"label":100,"population":103,"type":84,"unit":29,"dose":107,"refs":109,"allowedFormulations":112,"notes":113},"iv-child","sepsis",{"fa":101,"en":102},"وریدی — کودک: ۱۰ mg\u002Fkg هر ۶ ساعت (انفوزیون حداقل ۶۰ دقیقه)","IV — child: 10 mg\u002Fkg every 6 h (infuse over ≥60 min)",{"minAge":104,"maxAge":106},{"value":5,"unit":105},"month",{"value":66,"unit":67},{"perKgPerDose":75,"intervalHours":108},6,[110],{"source":34,"section":111},"Dosage and Administration — Pediatric patients",[23],[114],{"text":115,"refs":118},{"fa":116,"en":117},"سطح سرمی پایش شود. نوزاد: ۱۵ mg\u002Fkg سپس ۱۰ mg\u002Fkg هر ۱۲ ساعت (هفته اول) و هر ۸ ساعت تا ۱ ماهگی.","Monitor serum levels. Neonates: 15 mg\u002Fkg then 10 mg\u002Fkg every 12 h (first week) and every 8 h up to 1 month.",[119],{"source":34,"section":120},"Dosage and Administration — Neonates",{"id":122,"disease":99,"label":123,"population":126,"type":128,"unit":29,"dose":129,"refs":133},"iv-adult",{"fa":124,"en":125},"وریدی — بزرگسال: ۵۰۰ mg هر ۶ ساعت یا ۱ g هر ۱۲ ساعت","IV — adult: 500 mg every 6 h or 1 g every 12 h",{"minAge":127},{"value":66,"unit":67},"notCalculated",{"reason":130},{"fa":131,"en":132},"برچسب: ۲ g در روز (۵۰۰ mg هر ۶ ساعت یا ۱ g هر ۱۲ ساعت)، هر دوز حداکثر ۱۰ mg\u002Fmin یا حداقل ۶۰ دقیقه؛ در نارسایی کلیه و سالمندان کاهش دوز و پایش سطح.","Label: 2 g\u002Fday (500 mg every 6 h or 1 g every 12 h), each dose ≤10 mg\u002Fmin or over ≥60 min; reduce in renal impairment and the elderly, monitor levels.",[134],{"source":34,"section":135},"Dosage and Administration — Adults",[137],{"id":138,"severity":139,"text":140,"refs":143},"hyper","block",{"fa":141,"en":142},"حساسیت به ونکومایسین.","Hypersensitivity to vancomycin.",[144],{"source":34,"section":145},"Contraindications",[147],{"text":148,"refs":151},{"fa":149,"en":150},"تزریق سریع: افت فشار و شوک؛ واکنش‌های تزریق (گرگرفتگی، قرمزی، کهیر، خارش)؛ آسیب حاد کلیه با مواجهه بالا.","Rapid infusion: hypotension and shock; infusion reactions (flushing, erythema, urticaria, pruritus); acute kidney injury with high exposure.",[152],{"source":34,"section":153},"Warnings",[],[],[],{"status":158,"reviewer":159,"date":159},"unverified",null,[161,166,171],{"regimen":59,"formulation":37,"input":162,"expect":165},{"ageYears":163,"weightKg":164},50,70,{"perDose":42,"tabletsPerDoseRounded":5},{"regimen":78,"formulation":37,"input":167,"expect":169},{"ageYears":75,"weightKg":168},25,{"perDose":53,"tabletsPerDoseRounded":170},2,{"regimen":98,"formulation":23,"input":172,"expect":174},{"ageYears":108,"weightKg":173},20,{"perDose":175},200,[177,178],"J01XA01","A07AA09",{"status":180,"forms":181,"refs":202},"registered",[182,186,190,194,198],{"code":183,"en":184,"fa":185},"17886","VANCOMYCIN HCL 1G VIAL","ویال وانکومایسین هیدروکلراید ۱ گرم",{"code":187,"en":188,"fa":189},"01702","VANCOMYCIN HCL 250MG CAP","کپسول وانکومایسین هیدروکلراید ۲۵۰ میلی‌گرم",{"code":191,"en":192,"fa":193},"01276","VANCOMYCIN HCL 500MG VIAL","ویال وانکومایسین هیدروکلراید ۵۰۰ میلی‌گرم",{"code":195,"en":196,"fa":197},"01703","VANCOMYCIN HCL 500MG\u002F6ML 120ML SUSP","سوسپانسیون وانکومایسین هیدروکلراید ۵۰۰ میلی‌گرم \u002F ۶ میلی‌لیتر ۱۲۰ میلی‌لیتر",{"code":199,"en":200,"fa":201},"52200","VANCOMYCIN (AS HYDROCHLORIDE) CAPSULE, LIQUID FILLED ORAL 125 mg","کپسول وانکومایسین (معادل هیدروکلراید) پرشده ۱۲۵ میلی‌گرم",[203],{"source":204,"section":205,"url":206},"darooyab-generic","G-565\u002FVancomycin","https:\u002F\u002Fwww.darooyab.ir\u002FG-565\u002FVancomycin",{"kind":208,"refs":209,"id":212},"ANDA",[210],{"source":34,"section":211},"SPL approval \u002F marketing category","ANDA205694",[214,217,221,224,227,230,233,235],{"kind":215,"url":216,"label":212},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=205694",{"kind":218,"url":219,"label":220},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=b79d9671-02dd-40e2-97fb-a6c7be85cda1","FDA Vancomycin inj.",{"kind":218,"url":222,"label":223},"https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=bc737938-ae36-460b-a2a8-609f3fe59156","FDA Vancomycin caps",{"kind":225,"url":226,"label":8},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa604038.html",{"kind":225,"url":228,"label":229},"https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa601167.html","Vancomycin Injection",{"kind":231,"url":232,"label":177},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=J01XA01",{"kind":231,"url":234,"label":178},"https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=A07AA09",{"kind":236,"url":206,"label":8},"darooyab",{"pregnancy":238,"lactation":247,"pediatric":256,"geriatric":264},{"level":239,"text":240,"quote":243,"refs":244},"caution",{"fa":241,"en":242},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","Teratogenic Effects Animal reproduction studies have not been conducted with vancomycin.",[245],{"source":34,"section":246},"Pregnancy",{"level":248,"text":249,"quote":252,"refs":253},"avoid",{"fa":250,"en":251},"برچسب: شیردهی توصیه نمی‌شود یا باید بین دارو و شیردهی یکی انتخاب شود.","Label: breastfeeding not recommended, or choose between the drug and breastfeeding.","Because of the potential for adverse events, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.",[254],{"source":34,"section":255},"Nursing Mothers",{"level":239,"text":257,"quote":260,"refs":261},{"fa":258,"en":259},"برچسب برای کودکان شرط، محدودیت سنی یا نکته دارد؛ جمله برچسب در زیر آمده است.","The label has conditions, age limits or notes for children; the label sentence is quoted below.","In pediatric patients, it may be appropriate to confirm desired vancomycin serum concentrations.",[262],{"source":34,"section":263},"Pediatric Use",{"level":239,"text":265,"quote":268,"refs":269},{"fa":266,"en":267},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","The natural decrement of glomerular filtration with increasing age may lead to elevated vancomycin serum concentrations if dosage is not adjusted.",[270],{"source":34,"section":271},"Geriatric Use",1792100122661]