[{"data":1,"prerenderedAt":169},["ShallowReactive",2],{"drug-trospium":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":20,"regimens":35,"contraindications":59,"warnings":69,"renal":77,"monitoring":86,"interactions":87,"review":88,"examples":91,"atc":97,"iran":99,"links":111,"populations":129,"usApproval":164},"trospium",1,{"fa":7,"en":8},"تروسپیوم","Trospium","genitourinary-sex-hormones",{"fa":11,"en":12},"آنتی‌موسکارینی (آمین چهارتایی)","Quaternary-amine antimuscarinic",[14],{"name":15,"market":16},"Sanctura","US",[18,19,7],"sanctura","spasmex",[21],{"id":22,"form":23,"route":24,"label":25,"concentration":26,"markets":30,"refs":31},"tab-20","tablet","oral","20 mg tablet",{"amount":27,"unit":28,"perUnit":23,"scored":29},20,"mg",false,[16],[32],{"source":33,"section":34},"fda-trospium","3",[36],{"id":37,"disease":38,"label":39,"population":42,"type":46,"unit":28,"dose":47,"refs":49,"notes":52},"oab","overactive-bladder",{"fa":40,"en":41},"مثانه بیش‌فعال بزرگسال — ۲۰ mg دو بار، دست‌کم ۱ ساعت پیش از غذا","Overactive bladder, adults — 20 mg twice daily, at least 1 h before meals",{"minAge":43},{"value":44,"unit":45},18,"year","fixed",{"perDose":27,"dosesPerDay":48},2,[50],{"source":33,"section":51},"2",[53],{"text":54,"refs":57},{"fa":55,"en":56},"۷۵ سال به بالا: بر اساس تحمل تا ۲۰ mg یک بار.","≥75 y: may reduce to 20 mg once daily by tolerability.",[58],{"source":33,"section":51},[60],{"id":61,"severity":62,"text":63,"refs":66},"ci","block",{"fa":64,"en":65},"احتباس ادرار؛ احتباس معده؛ گلوکوم زاویه بسته کنترل‌نشده؛ حساسیت.","Urinary retention; gastric retention; uncontrolled narrow-angle glaucoma; hypersensitivity.",[67],{"source":33,"section":68},"4",[70],{"text":71,"refs":74},{"fa":72,"en":73},"احتباس ادرار (به‌ویژه با انسداد خروجی مثانه)؛ آنژیوادم؛ کاهش حرکات گوارش؛ عوارض CNS (گیجی، خواب‌آلودگی).","Urinary retention (especially with bladder outlet obstruction); angioedema; decreased GI motility; CNS effects (confusion, somnolence).",[75],{"source":33,"section":76},"5",[78],{"egfrBelow":79,"severity":80,"text":81,"refs":84},30,"warn",{"fa":82,"en":83},"ClCr زیر ۳۰: ۲۰ mg یک بار هنگام خواب.","CrCl \u003C30: 20 mg once daily at bedtime.",[85],{"source":33,"section":51},[],[],{"status":89,"reviewer":90,"date":90},"unverified",null,[92],{"regimen":37,"formulation":22,"input":93,"expect":96},{"ageYears":94,"weightKg":95},60,70,{"perDose":27,"tabletsPerDoseRounded":5},[98],"G04BD09",{"status":100,"forms":101,"refs":106},"registered",[102],{"code":103,"en":104,"fa":105},"16102","TROSPIUM 20MG TAB","قرص تروسپیوم ۲۰ میلی‌گرم",[107],{"source":108,"section":109,"url":110},"darooyab-generic","G-932\u002FTrospium-Chloride","https:\u002F\u002Fwww.darooyab.ir\u002FG-932\u002FTrospium-Chloride",[112,116,120,123,126],{"kind":113,"url":114,"label":115},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=204945","ANDA204945",{"kind":117,"url":118,"label":119},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=570c3ae7-8011-4944-8935-57d0a66102aa","FDA Trospium",{"kind":121,"url":122,"label":8},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa604037.html",{"kind":124,"url":125,"label":98},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=G04BD09",{"kind":127,"url":110,"label":128},"darooyab","Trospium-Chloride",{"pregnancy":130,"lactation":139,"pediatric":147,"geriatric":156},{"level":131,"text":132,"quote":135,"refs":136},"caution",{"fa":133,"en":134},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","Teratogenic Effects Pregnancy Category C: There are no adequate and well-controlled studies of trospium chloride in pregnant women.",[137],{"source":33,"section":138},"8.1",{"level":131,"text":140,"quote":143,"refs":144},{"fa":141,"en":142},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","Trospium chloride (2 mg\u002Fkg orally and 50 mcg\u002Fkg intravenously) was excreted, to a limited extent (less than 1%), into the milk of lactating rats (primarily as parent compound).",[145],{"source":33,"section":146},"8.3",{"level":148,"text":149,"quote":152,"refs":153},"not-established",{"fa":150,"en":151},"برچسب: ایمنی و اثربخشی در کودکان ثابت نشده است.","Label: safety and effectiveness in children have not been established.","The safety and effectiveness of trospium chloride in pediatric patients have not been established.",[154],{"source":33,"section":155},"8.4",{"level":131,"text":157,"quote":160,"refs":161},{"fa":158,"en":159},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","Therefore, based upon tolerability, the dose frequency of trospium chloride may be reduced to 20 mg once daily in patients 75 years of age and older.",[162],{"source":33,"section":163},"8.5",{"kind":165,"refs":166,"id":115},"ANDA",[167],{"source":33,"section":168},"SPL approval \u002F marketing category",1792191570978]