[{"data":1,"prerenderedAt":151},["ShallowReactive",2],{"drug-tri-luma":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":21,"regimens":33,"contraindications":54,"warnings":64,"renal":72,"monitoring":73,"interactions":74,"review":75,"examples":78,"iran":79,"usApproval":95,"links":101,"populations":116},"tri-luma",1,{"fa":7,"en":8},"کرم سه‌گانه ملاسما (فلوسینولون + هیدروکینون + ترتینوئین)","Fluocinolone + hydroquinone + tretinoin cream","dermatology",{"fa":11,"en":12},"ترکیب ضدلک","Depigmenting combination",[14],{"name":15,"market":16},"Tri-Luma","US",[4,18,19,20],"تری لوما","هیدروکینون","کرم ضد لک",[22],{"id":23,"form":23,"route":24,"label":25,"concentration":26,"markets":28,"refs":29},"cream","topical","Fluocinolone 0.01% \u002F hydroquinone 4% \u002F tretinoin 0.05% cream",{"amount":5,"unit":27,"perUnit":27},"application",[16],[30],{"source":31,"section":32},"fda-triluma","3",[34],{"id":35,"disease":35,"label":36,"population":39,"type":43,"unit":44,"dose":45,"refs":49},"melasma",{"fa":37,"en":38},"ملاسمای متوسط تا شدید صورت — لایه نازک شب‌ها، کوتاه‌مدت","Moderate–severe facial melasma — thin film nightly, short-term",{"minAge":40},{"value":41,"unit":42},18,"year","notCalculated","mg",{"reason":46},{"fa":47,"en":48},"یک بار در روز دست‌کم ۳۰ دقیقه پیش از خواب، لایه نازک روی لک‌ها و حدود ۱ سانتی‌متر پوست سالم اطراف. با کنترل لک قطع شود. روزها ضدآفتاب SPF 30 و پرهیز از آفتاب.","Once daily at least 30 min before bedtime, a thin film on the patches and about 1\u002F2 inch of surrounding skin. Stop when controlled. Daytime SPF 30 sunscreen and sun avoidance.",[50,52],{"source":31,"section":51},"2",{"source":31,"section":53},"1",[55],{"id":56,"severity":57,"text":58,"refs":61},"hyper","block",{"fa":59,"en":60},"حساسیت به هر یک از اجزا.","Hypersensitivity to any component.",[62],{"source":31,"section":63},"4",[65],{"text":66,"refs":69},{"fa":67,"en":68},"حاوی سولفیت (واکنش آلرژیک و حمله آسم در افراد حساس).","Contains sulfite (allergic reactions and asthma attacks in susceptible people).",[70],{"source":31,"section":71},"5",[],[],[],{"status":76,"reviewer":77,"date":77},"unverified",null,[],{"status":80,"forms":81,"refs":90},"registered",[82,86],{"code":83,"en":84,"fa":85},"00546","FLUOCINOLONE ACETONIDE 0.025% 15G CREAM","کرم فلوئوسینولون استوناید ۰٫۰۲۵ درصد ۱۵ گرم",{"code":87,"en":88,"fa":89},"00545","FLUOCINOLONE ACETONIDE 0.025% 15G OINT","پماد فلوئوسینولون استوناید ۰٫۰۲۵ درصد ۱۵ گرم",[91],{"source":92,"section":93,"url":94},"darooyab-generic","G-2101\u002FFluocinolone","https:\u002F\u002Fwww.darooyab.ir\u002FG-2101\u002FFluocinolone",{"kind":96,"refs":97,"id":100},"NDA",[98],{"source":31,"section":99},"SPL approval \u002F marketing category","NDA021112",[102,105,109,113],{"kind":103,"url":104,"label":100},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=021112",{"kind":106,"url":107,"label":108},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=a35fa709-5eb5-4429-b38f-f1e0019bf0ee","FDA Tri-Luma",{"kind":110,"url":111,"label":112},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa682271.html","Fluocinolone Topical",{"kind":114,"url":94,"label":115},"darooyab","Fluocinolone",{"pregnancy":117,"lactation":126,"pediatric":134,"geriatric":143},{"level":118,"text":119,"quote":122,"refs":123},"caution",{"fa":120,"en":121},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","Teratogenic Effects: Pregnancy Category C There are no adequate and well-controlled studies in pregnant women.",[124],{"source":31,"section":125},"8.1",{"level":118,"text":127,"quote":130,"refs":131},{"fa":128,"en":129},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","Because many drugs are secreted in human milk, caution should be exercised when TRI-LUMA Cream is administered to a nursing woman.",[132],{"source":31,"section":133},"8.3",{"level":135,"text":136,"quote":139,"refs":140},"not-established",{"fa":137,"en":138},"برچسب: ایمنی و اثربخشی در کودکان ثابت نشده است.","Label: safety and effectiveness in children have not been established.","Safety and effectiveness of TRI-LUMA Cream in pediatric patients have not been established.",[141],{"source":31,"section":142},"8.4",{"level":118,"text":144,"quote":147,"refs":148},{"fa":145,"en":146},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal or cardiac function, and of concomitant disease or other drug therapy.",[149],{"source":31,"section":150},"8.5",1792111454423]