[{"data":1,"prerenderedAt":178},["ShallowReactive",2],{"drug-tretinoin-topical":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":22,"regimens":34,"contraindications":53,"warnings":54,"renal":62,"monitoring":63,"interactions":64,"review":65,"examples":68,"atc":69,"iran":71,"usApproval":118,"links":124,"populations":144},"tretinoin-topical",1,{"fa":7,"en":8},"ترتینوئین موضعی","Tretinoin (topical)","dermatology",{"fa":11,"en":12},"رتینوئید موضعی","Topical retinoid",[14],{"name":15,"market":16},"Retin-A Micro","US",[18,19,20,21],"retin-a","رتین ای","ترتینوئین","ترتینوئین کرم",[23],{"id":24,"form":24,"route":25,"label":26,"concentration":27,"markets":29,"refs":30},"gel","topical","Tretinoin gel 0.04%, 0.06%, 0.08% or 0.1%",{"amount":5,"unit":28,"perUnit":28},"application",[16],[31],{"source":32,"section":33},"fda-retin-a-micro","3",[35],{"id":36,"disease":36,"label":37,"population":40,"type":44,"unit":45,"dose":46,"refs":50},"acne",{"fa":38,"en":39},"آکنه — لایه نازک یک بار در روز، عصر","Acne — thin layer once daily in the evening",{"minAge":41},{"value":42,"unit":43},12,"year","notCalculated","mg",{"reason":47},{"fa":48,"en":49},"پس از شستن ملایم و خشک کردن، لایه نازک روی کل ناحیه آکنه یک بار در روز عصر؛ دور از چشم، دهان، چین‌های بینی و مخاط. بیش از لایه نازک نه. بهبود از ۲ هفته به بعد.","After gentle cleansing and drying, a thin layer over the whole acne area once daily in the evening; away from eyes, mouth, nasal creases and mucosa. No more than a thin layer. Improvement from about 2 weeks.",[51],{"source":32,"section":52},"2",[],[55],{"text":56,"refs":59},{"fa":57,"en":58},"تحریک موضعی (خشکی، قرمزی، پوسته‌ریزی، سوزش)؛ روی پوست اگزمایی یا در هوای خیلی سرد یا بادی مصرف نشود؛ از آفتاب پرهیز.","Local irritation (dryness, redness, peeling, burning); avoid eczematous skin and extreme wind or cold; avoid sun.",[60],{"source":32,"section":61},"5",[],[],[],{"status":66,"reviewer":67,"date":67},"unverified",null,[],[70],"D10AD01",{"status":72,"forms":73,"refs":113},"registered",[74,78,82,86,90,94,98,102,106,110],{"code":75,"en":76,"fa":77},"01244","TRETINOIN 0.025% GEL","ژل ترتینوئین ۰٫۰۲۵ درصد",{"code":79,"en":80,"fa":81},"01245","TRETINOIN 0.05% 15G CREAM","کرم ترتینوئین ۰٫۰۵ درصد ۱۵ گرم",{"code":83,"en":84,"fa":85},"21707","TRETINOIN 0.05% 30G TOP CREAM","کرم ترتینوئین ۰٫۰۵ درصد ۳۰ گرم",{"code":87,"en":88,"fa":89},"01696","TRETINOIN 0.05% GEL","ژل ترتینوئین ۰٫۰۵ درصد",{"code":91,"en":92,"fa":93},"01246","TRETINOIN 0.05% LOTION","لوسیون ترتینوئین ۰٫۰۵ درصد",{"code":95,"en":96,"fa":97},"18591","TRETINOIN 0.1% 20G CREAM","کرم ترتینوئین ۰٫۱ درصد ۲۰ گرم",{"code":99,"en":100,"fa":101},"03431","TRETINOIN 10MG CAP","کپسول ترتینوئین ۱۰ میلی‌گرم",{"code":103,"en":104,"fa":105},"15871","TRETINOIN 10MG TAB","قرص ترتینوئین ۱۰ میلی‌گرم",{"code":107,"en":108,"fa":109},"01243","TRETINOIN_BULK","ماده اولیه ترتینوئین",{"code":111,"en":112,"fa":85},"52304","TRETINOIN CREAM TOPICAL 0.05 % 30 g",[114],{"source":115,"section":116,"url":117},"darooyab-generic","G-2338\u002FTretinoin","https:\u002F\u002Fwww.darooyab.ir\u002FG-2338\u002FTretinoin",{"kind":119,"refs":120,"id":123},"NDA",[121],{"source":32,"section":122},"SPL approval \u002F marketing category","NDA020475",[125,128,132,136,139,142],{"kind":126,"url":127,"label":123},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=020475",{"kind":129,"url":130,"label":131},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=08ab7e0c-1437-455f-815c-98904d96a289","FDA Retin-A Micro",{"kind":133,"url":134,"label":135},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa608032.html","Tretinoin",{"kind":133,"url":137,"label":138},"https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa682437.html","Tretinoin Topical",{"kind":140,"url":141,"label":70},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=D10AD01",{"kind":143,"url":117,"label":135},"darooyab",{"pregnancy":145,"lactation":154,"pediatric":162,"geriatric":170},{"level":146,"text":147,"quote":150,"refs":151},"caution",{"fa":148,"en":149},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","Risk Summary Available data from published prospective observational studies and retrospective cohort studies over decades of use of topical tretinoin in pregnant women have not established a drug-associated risk of major birth defects, miscarriage, or adverse maternal or fetal outcomes (see Data) .",[152],{"source":32,"section":153},"8.1",{"level":146,"text":155,"quote":158,"refs":159},{"fa":156,"en":157},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","Risk Summary There are no data on the presence of tretinoin or its metabolites in human milk, the effects on the breastfed infant, or the effects on milk production.",[160],{"source":32,"section":161},"8.2",{"level":146,"text":163,"quote":166,"refs":167},{"fa":164,"en":165},"برچسب برای کودکان شرط، محدودیت سنی یا نکته دارد؛ جمله برچسب در زیر آمده است.","The label has conditions, age limits or notes for children; the label sentence is quoted below.","The safety and effectiveness of RETIN-A MICRO for topical application for the treatment of acne vulgaris have been established in pediatric patients aged 12 years and older [see Clinical Studies (14) ] .",[168],{"source":32,"section":169},"8.4",{"level":146,"text":171,"quote":174,"refs":175},{"fa":172,"en":173},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","Clinical trials of RETIN-A MICRO did not include sufficient numbers of subjects aged 65 and over to determine whether they responded differently from younger adult subjects.",[176],{"source":32,"section":177},"8.5",1792111470380]