[{"data":1,"prerenderedAt":201},["ShallowReactive",2],{"drug-tobramycin-dexamethasone-eye":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":21,"regimens":34,"contraindications":58,"warnings":68,"renal":69,"monitoring":70,"interactions":71,"review":72,"examples":75,"atc":81,"iran":83,"usApproval":139,"links":145,"populations":166},"tobramycin-dexamethasone-eye",1,{"fa":7,"en":8},"قطره چشمی توبرامایسین + دگزامتازون","Tobramycin + dexamethasone eye drops","sensory-organs",{"fa":11,"en":12},"آنتی‌بیوتیک + کورتیکواستروئید چشمی","Ophthalmic antibiotic + corticosteroid",[14],{"name":15,"market":16},"TobraDex","US",[18,19,20],"tobradex","توبرادکس","توبرامایسین دگزامتازون",[22],{"id":23,"form":24,"route":25,"label":26,"concentration":27,"markets":29,"refs":30},"susp","eye-drops","ophthalmic","Tobramycin 0.3% + dexamethasone 0.05% suspension",{"amount":5,"unit":28,"perUnit":28},"drop",[16],[31],{"source":32,"section":33},"fda-tobradex-st","3",[35],{"id":36,"disease":37,"label":38,"population":41,"type":45,"unit":28,"dose":46,"refs":48,"notes":51},"std","ocular-inflammation",{"fa":39,"en":40},"التهاب چشم پاسخ‌دهنده به کورتون با عفونت یا خطر عفونت باکتریایی — یک قطره هر ۴ تا ۶ ساعت","Steroid-responsive eye inflammation with bacterial infection or risk — 1 drop every 4–6 h",{"minAge":42},{"value":43,"unit":44},2,"year","fixed",{"perDose":5,"dosesPerDay":47},4,[49],{"source":32,"section":50},"2.1",[52],{"text":53,"refs":56},{"fa":54,"en":55},"در ۲۴ تا ۴۸ ساعت اول می‌توان هر ۲ ساعت. با بهبود به‌تدریج کم شود. پیش از تجویز و تمدید فشار چشم و معاینه با اسلیت‌لامپ.","In the first 24–48 h may be every 2 h. Taper gradually with improvement. Check IOP and slit-lamp examination before prescribing and renewing.",[57],{"source":32,"section":50},[59],{"id":60,"severity":61,"text":62,"refs":65},"ci","block",{"fa":63,"en":64},"بیشتر بیماری‌های ویروسی قرنیه و ملتحمه (هرپس دندریتیک، واکسینیا، آبله‌مرغان)، عفونت مایکوباکتریایی یا قارچی چشم؛ حساسیت.","Most viral diseases of cornea and conjunctiva (dendritic herpes, vaccinia, varicella), mycobacterial or fungal eye infection; hypersensitivity.",[66],{"source":32,"section":67},"4",[],[],[],[],{"status":73,"reviewer":74,"date":74},"unverified",null,[76],{"regimen":36,"formulation":23,"input":77,"expect":80},{"ageYears":78,"weightKg":79},40,70,{"perDose":5,"dosesPerDay":47},[82],"S01CA01",{"status":84,"forms":85,"refs":134},"registered",[86,90,94,98,102,106,110,114,118,122,126,130],{"code":87,"en":88,"fa":89},"18882","TOBRAMYCIN 0.3% OPH OINT","پماد توبرامایسین ۰٫۳ درصد",{"code":91,"en":92,"fa":93},"13022","TOBRAMYCIN 100MG\u002F2ML  INJ","فرآورده تزریقی توبرامایسین ۱۰۰ میلی‌گرم \u002F ۲ میلی‌لیتر",{"code":95,"en":96,"fa":97},"02189","TOBRAMYCIN 10MG\u002FML 2ML AMP","آمپول توبرامایسین ۱۰ میلی‌گرم \u002F میلی‌لیتر ۲ میلی‌لیتر",{"code":99,"en":100,"fa":101},"21537","TOBRAMYCIN 28MG INHALER","فرآورده استنشاقی توبرامایسین ۲۸ میلی‌گرم",{"code":103,"en":104,"fa":105},"16775","TOBRAMYCIN 300MG\u002F4ML NEBULISATION SOLUTION","محلول توبرامایسین ۳۰۰ میلی‌گرم \u002F ۴ میلی‌لیتر نبولایزیشن",{"code":107,"en":108,"fa":109},"11619","TOBRAMYCIN 300MG\u002F5ML AMP","آمپول توبرامایسین ۳۰۰ میلی‌گرم \u002F ۵ میلی‌لیتر",{"code":111,"en":112,"fa":113},"19893","TOBRAMYCIN 300MG\u002F5ML NEBULISATION","توبرامایسین ۳۰۰ میلی‌گرم \u002F ۵ میلی‌لیتر نبولایزیشن",{"code":115,"en":116,"fa":117},"12781","TOBRAMYCIN 40MG\u002F1ML  INJ","فرآورده تزریقی توبرامایسین ۴۰ میلی‌گرم \u002F ۱ میلی‌لیتر",{"code":119,"en":120,"fa":121},"01229","TOBRAMYCIN 40MG\u002FML 2ML AMP","آمپول توبرامایسین ۴۰ میلی‌گرم \u002F میلی‌لیتر ۲ میلی‌لیتر",{"code":123,"en":124,"fa":125},"06668","TOBRAMYCIN 75MG\u002F1.5ML AMP","آمپول توبرامایسین ۷۵ میلی‌گرم \u002F ۱٫۵ میلی‌لیتر",{"code":127,"en":128,"fa":129},"12805","TOBRAMYCIN 80MG\u002FML 2ML AMP","آمپول توبرامایسین ۸۰ میلی‌گرم \u002F میلی‌لیتر ۲ میلی‌لیتر",{"code":131,"en":132,"fa":133},"51698","TOBRAMYCIN SOLUTION RESPIRATORY 60 mg\u002F1mL 5 mL","محلول توبرامایسین ۶۰ میلی‌گرم \u002F ۱ میلی‌لیتر ۵ میلی‌لیتر",[135],{"source":136,"section":137,"url":138},"darooyab-generic","G-557\u002FTobramycin","https:\u002F\u002Fwww.darooyab.ir\u002FG-557\u002FTobramycin",{"kind":140,"refs":141,"id":144},"NDA",[142],{"source":32,"section":143},"SPL approval \u002F marketing category","NDA050818",[146,149,153,157,160,163],{"kind":147,"url":148,"label":144},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=050818",{"kind":150,"url":151,"label":152},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=3b99dbb3-ac84-4d0d-b30f-a5db44fdc316","FDA TobraDex ST",{"kind":154,"url":155,"label":156},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa681003.html","Tobramycin Injection",{"kind":154,"url":158,"label":159},"https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa682660.html","Tobramycin Ophthalmic",{"kind":161,"url":162,"label":82},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=S01CA01",{"kind":164,"url":138,"label":165},"darooyab","Tobramycin",{"pregnancy":167,"lactation":176,"pediatric":184,"geriatric":192},{"level":168,"text":169,"quote":172,"refs":173},"caution",{"fa":170,"en":171},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","TOBRADEX ST ophthalmic suspension should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus [see Nonclinical Toxicology (13.1) ] .",[174],{"source":32,"section":175},"8.1",{"level":168,"text":177,"quote":180,"refs":181},{"fa":178,"en":179},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","Because many drugs are excreted in human milk, caution should be exercised when TOBRADEX ST is administered to a nursing woman.",[182],{"source":32,"section":183},"8.3",{"level":168,"text":185,"quote":188,"refs":189},{"fa":186,"en":187},"برچسب برای کودکان شرط، محدودیت سنی یا نکته دارد؛ جمله برچسب در زیر آمده است.","The label has conditions, age limits or notes for children; the label sentence is quoted below.","Safety and effectiveness in pediatric patients below the age of 2 years have not been established.",[190],{"source":32,"section":191},"8.4",{"level":193,"text":194,"quote":197,"refs":198},"ok",{"fa":195,"en":196},"برچسب: در سالمندان تفاوت یا تنظیم دوز خاصی ذکر نشده.","Label: no specific difference or dose adjustment stated for older adults.","No overall differences in safety or effectiveness have been observed between elderly and younger patients.",[199],{"source":32,"section":200},"8.5",1792115197841]