[{"data":1,"prerenderedAt":212},["ShallowReactive",2],{"drug-tenofovir-df":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":22,"regimens":61,"contraindications":100,"warnings":101,"renal":109,"monitoring":110,"interactions":111,"review":112,"examples":114,"atc":125,"iran":127,"links":151,"populations":173,"usApproval":207},"tenofovir-df",1,{"fa":7,"en":8},"تنوفوویر دیزوپروکسیل","Tenofovir disoproxil fumarate","anti-infectives",{"fa":11,"en":12},"آنالوگ نوکلئوتیدی ضد HBV\u002FHIV","Nucleotide analogue (HBV\u002FHIV)",[14],{"name":15,"market":16},"Viread","US",[18,19,20,21],"viread","ویرید","تنوفوویر","TDF",[23,37,45,53],{"id":24,"form":25,"route":26,"label":27,"concentration":28,"markets":32,"refs":33},"tab-150","tablet","oral","150 mg tablet",{"amount":29,"unit":30,"perUnit":25,"scored":31},150,"mg",false,[16],[34],{"source":35,"section":36},"fda-viread","3",{"id":38,"form":25,"route":26,"label":39,"concentration":40,"markets":42,"refs":43},"tab-200","200 mg tablet",{"amount":41,"unit":30,"perUnit":25,"scored":31},200,[16],[44],{"source":35,"section":36},{"id":46,"form":25,"route":26,"label":47,"concentration":48,"markets":50,"refs":51},"tab-250","250 mg tablet",{"amount":49,"unit":30,"perUnit":25,"scored":31},250,[16],[52],{"source":35,"section":36},{"id":54,"form":25,"route":26,"label":55,"concentration":56,"markets":58,"refs":59},"tab-300","300 mg tablet",{"amount":57,"unit":30,"perUnit":25,"scored":31},300,[16],[60],{"source":35,"section":36},[62],{"id":63,"disease":64,"label":65,"population":68,"type":73,"unit":30,"dose":74,"refs":85,"notes":88},"hbv","hepatitis-b",{"fa":66,"en":67},"هپاتیت B مزمن — یک بار در روز بر اساس وزن (۲ سال به بالا، ۱۷ kg به بالا برای قرص)","Chronic hepatitis B — once daily by weight (≥2 y, ≥17 kg for tablets)",{"minAge":69,"minWeightKg":72},{"value":70,"unit":71},2,"year",17,"weightBand",{"weightBands":75},[76,79,81,83],{"minWeightKg":77,"maxWeightKg":78,"perDose":29,"dosesPerDay":5},16.99,21.99,{"minWeightKg":78,"maxWeightKg":80,"perDose":41,"dosesPerDay":5},27.99,{"minWeightKg":80,"maxWeightKg":82,"perDose":49,"dosesPerDay":5},34.99,{"minWeightKg":82,"maxWeightKg":84,"perDose":57,"dosesPerDay":5},null,[86],{"source":35,"section":87},"2.2, Table 1",[89],{"text":90,"refs":93},{"fa":91,"en":92},"با یا بدون غذا. دوز HIV همین است. پیش از شروع، تست HIV و HBV؛ کراتینین، CrCl، قند و پروتئین ادرار. CrCl ۳۰ تا ۴۹: هر ۴۸ ساعت؛ ۱۰ تا ۲۹: هر ۷۲ تا ۹۶ ساعت؛ همودیالیز: هفته‌ای یک بار پس از دیالیز.","With or without food. Same dose for HIV. Before starting test for HIV and HBV; creatinine, CrCl, urine glucose and protein. CrCl 30–49: every 48 h; 10–29: every 72–96 h; haemodialysis: weekly after dialysis.",[94,96,98],{"source":35,"section":95},"2.2",{"source":35,"section":97},"2.4",{"source":35,"section":99},"2",[],[102],{"text":103,"refs":106},{"fa":104,"en":105},"هشدار جعبه‌ای: تشدید شدید هپاتیت B پس از قطع؛ کبد تا چند ماه پایش شود.","Boxed warning: severe acute exacerbation of hepatitis B after stopping; monitor liver for several months.",[107],{"source":35,"section":108},"Boxed Warning",[],[],[],{"status":113,"reviewer":84,"date":84},"unverified",[115,120],{"regimen":63,"formulation":54,"input":116,"expect":119},{"ageYears":117,"weightKg":118},40,70,{"perDose":57,"tabletsPerDoseRounded":5},{"regimen":63,"formulation":38,"input":121,"expect":124},{"ageYears":122,"weightKg":123},8,25,{"perDose":41,"tabletsPerDoseRounded":5},[126],"J05AF07",{"status":128,"forms":129,"refs":146},"registered",[130,134,138,142],{"code":131,"en":132,"fa":133},"16918","TENOFOVIR 245MG TAB","قرص تنوفوویر ۲۴۵ میلی‌گرم",{"code":135,"en":136,"fa":137},"13524","TENOFOVIR 300MG TAB","قرص تنوفوویر ۳۰۰ میلی‌گرم",{"code":139,"en":140,"fa":141},"51976","TENOFOVIR 25MG TAB","قرص تنوفوویر ۲۵ میلی‌گرم",{"code":143,"en":144,"fa":145},"52153","TENOFOVIR DISOPROXIL FUMARATE TABLET ORAL 200 mg","قرص تنوفوویر دیسوپروکسیل فومارات ۲۰۰ میلی‌گرم",[147],{"source":148,"section":149,"url":150},"darooyab-generic","G-1205\u002FTenofovir","https:\u002F\u002Fwww.darooyab.ir\u002FG-1205\u002FTenofovir",[152,156,160,164,167,170],{"kind":153,"url":154,"label":155},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=021356","NDA021356",{"kind":157,"url":158,"label":159},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=33fd6418-fbdc-42ca-a50d-ce2a476a5418","FDA Viread",{"kind":161,"url":162,"label":163},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa618049.html","Doravirine, Lamivudine, and Tenofovir disoproxil fumarate",{"kind":161,"url":165,"label":166},"https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa616048.html","Efavirenz, Emtricitabine, and Tenofovir disoproxil fumarate",{"kind":168,"url":169,"label":126},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=J05AF07",{"kind":171,"url":150,"label":172},"darooyab","Tenofovir",{"pregnancy":174,"lactation":183,"pediatric":191,"geriatric":199},{"level":175,"text":176,"quote":179,"refs":180},"caution",{"fa":177,"en":178},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","Risk Summary Available data from the APR show no increase in the overall risk of major birth defects with first trimester exposure for tenofovir disoproxil fumarate (TDF) (2.1%) compared with the background rate for major birth defects of 2.7% in a U.S. reference population of the Metropolitan Atlanta Congenital …",[181],{"source":35,"section":182},"8.1",{"level":175,"text":184,"quote":187,"refs":188},{"fa":185,"en":186},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","Risk Summary Based on published data, tenofovir has been shown to be present in human breast milk (see Data ).",[189],{"source":35,"section":190},"8.2",{"level":175,"text":192,"quote":195,"refs":196},{"fa":193,"en":194},"برچسب برای کودکان شرط، محدودیت سنی یا نکته دارد؛ جمله برچسب در زیر آمده است.","The label has conditions, age limits or notes for children; the label sentence is quoted below.","Safety and effectiveness of VIREAD in pediatric patients younger than 2 years of age and weighing less than 10 kg with HIV-1 infection have not been established.",[197],{"source":35,"section":198},"8.4",{"level":175,"text":200,"quote":203,"refs":204},{"fa":201,"en":202},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","In general, dose selection for the elderly patient should be cautious, keeping in mind the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy.",[205],{"source":35,"section":206},"8.5",{"kind":208,"refs":209,"id":155},"NDA",[210],{"source":35,"section":211},"SPL approval \u002F marketing category",1792108438090]