[{"data":1,"prerenderedAt":140},["ShallowReactive",2],{"drug-spinosad":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":21,"regimens":34,"contraindications":60,"warnings":72,"renal":73,"monitoring":74,"interactions":75,"review":76,"examples":79,"iran":85,"links":92,"populations":101,"usApproval":135},"spinosad",1,{"fa":7,"en":8},"سوسپانسیون اسپینوساد ۰٫۹٪ (شپش)","Spinosad 0.9% suspension","antiparasitic",{"fa":11,"en":12},"ضدشپش موضعی","Topical pediculicide",[14],{"name":15,"market":16},"Natroba","US",[18,19,20],"natroba","اسپینوساد","شپش",[22],{"id":23,"form":24,"route":25,"label":26,"concentration":27,"markets":29,"refs":30},"susp","suspension","topical","Spinosad 0.9% topical suspension, 120 mL",{"amount":5,"unit":28,"perUnit":28},"application",[16],[31],{"source":32,"section":33},"fda-natroba","3",[35],{"id":36,"disease":37,"label":38,"population":41,"type":45,"unit":28,"dose":46,"refs":47,"durationDays":50,"notes":51},"lice","head-lice",{"fa":39,"en":40},"شپش سر — ۶ ماه به بالا: روی پوست سر و موی خشک، ۱۰ دقیقه","Head lice — ≥6 months: on dry scalp and hair, 10 min",{"minAge":42},{"value":43,"unit":44},6,"month","fixed",{"perDose":5,"dosesPerDay":5},[48],{"source":32,"section":49},"2.2",{"min":5,"max":5},[52],{"text":53,"refs":56},{"fa":54,"en":55},"تا ۱۲۰ mL بسته به طول مو. اگر پس از ۷ روز شپش زنده دیده شد، تکرار. در کودک فقط با نظارت بزرگسال.","Up to 120 mL depending on hair length. Repeat if live lice seen after 7 days. In children only with adult supervision.",[57,58],{"source":32,"section":49},{"source":32,"section":59},"2",[61],{"id":62,"severity":63,"rule":64,"text":66,"refs":69},"lt6m","block",{"maxAge":65},{"value":43,"unit":44},{"fa":67,"en":68},"زیر ۶ ماه توصیه نمی‌شود (بنزیل الکل).","Not recommended under 6 months (benzyl alcohol).",[70],{"source":32,"section":71},"8.4",[],[],[],[],{"status":77,"reviewer":78,"date":78},"unverified",null,[80],{"regimen":36,"formulation":23,"input":81,"expect":84},{"ageYears":82,"weightKg":83},7,22,{"perDose":5},{"status":86,"refs":87},"not-found",[88],{"source":89,"section":90,"url":91},"darooyab-generic","search","https:\u002F\u002Fwww.darooyab.ir\u002FSearch?q=spinosad%200.9%25%20suspension",[93,97],{"kind":94,"url":95,"label":96},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=022408","NDA022408",{"kind":98,"url":99,"label":100},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=72cf38f4-9ef4-4b0e-b085-b02f399e2592","FDA Natroba",{"pregnancy":102,"lactation":111,"pediatric":119,"geriatric":127},{"level":103,"text":104,"quote":107,"refs":108},"ok",{"fa":105,"en":106},"برچسب: جذب سیستمیک ناچیز؛ مواجهه جنین انتظار نمی‌رود.","Label: minimal systemic absorption; fetal exposure not expected.","Risk Summary Spinosad, the active ingredient in NATROBA, is not absorbed systemically following topical application, and maternal use is not expected to result in fetal exposure to the drug.",[109],{"source":32,"section":110},"8.1",{"level":103,"text":112,"quote":115,"refs":116},{"fa":113,"en":114},"برچسب: مواجهه شیرخوار انتظار نمی‌رود.","Label: infant exposure not expected.","Topical benzyl alcohol is unlikely to be absorbed through the skin of breastfeeding women in clinically relevant amounts; therefore, breastfeeding is not expected to result in exposure of the infant to NATROBA [ see Clinical Pharmacology (12.3) ].",[117],{"source":32,"section":118},"8.2",{"level":120,"text":121,"quote":124,"refs":125},"caution",{"fa":122,"en":123},"برچسب برای کودکان شرط، محدودیت سنی یا نکته دارد؛ جمله برچسب در زیر آمده است.","The label has conditions, age limits or notes for children; the label sentence is quoted below.","Head Lice Infestation The safety and effectiveness of NATROBA for the topical treatment of head lice infestation have been established in pediatric patients 6 months of age and older [see Clinical Pharmacology (12.3) and Clinical Studies (14) ] .",[126],{"source":32,"section":71},{"level":120,"text":128,"quote":131,"refs":132},{"fa":129,"en":130},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","Clinical studies of NATROBA did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects.",[133],{"source":32,"section":134},"8.5",{"kind":136,"refs":137,"id":96},"NDA",[138],{"source":32,"section":139},"SPL approval \u002F marketing category",1792092044810]