[{"data":1,"prerenderedAt":170},["ShallowReactive",2],{"drug-sodium-zirconium-cyclosilicate":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":20,"regimens":42,"contraindications":88,"warnings":89,"renal":90,"monitoring":91,"interactions":92,"review":93,"examples":96,"atc":105,"iran":107,"links":114,"populations":130,"usApproval":165},"sodium-zirconium-cyclosilicate",1,{"fa":7,"en":8},"سدیم زیرکونیوم سیکلوسیلیکات","Sodium zirconium cyclosilicate","various",{"fa":11,"en":12},"جاذب پتاسیم","Potassium binder",[14],{"name":15,"market":16},"Lokelma","US",[18,19],"lokelma","لوکلما",[21,34],{"id":22,"form":23,"route":24,"label":25,"concentration":26,"markets":29,"refs":30},"sachet-5","sachet","oral","5 g sachet",{"amount":27,"unit":28,"perUnit":23},5,"g",[16],[31],{"source":32,"section":33},"fda-lokelma","3",{"id":35,"form":23,"route":24,"label":36,"concentration":37,"markets":39,"refs":40},"sachet-10","10 g sachet",{"amount":38,"unit":28,"perUnit":23},10,[16],[41],{"source":32,"section":33},[43,69],{"id":44,"disease":45,"label":46,"population":49,"type":53,"unit":28,"dose":54,"refs":56,"durationDays":59,"notes":61},"initial","hyperkalemia",{"fa":47,"en":48},"هیپرکالمی — شروع ۱۰ g سه بار در روز تا ۴۸ ساعت","Hyperkalaemia — initial 10 g three times daily for up to 48 h",{"minAge":50},{"value":51,"unit":52},18,"year","fixed",{"perDose":38,"dosesPerDay":55},3,[57],{"source":32,"section":58},"2.1",{"min":5,"max":60},2,[62],{"text":63,"refs":66},{"fa":64,"en":65},"در حدود ۳ قاشق آب. سایر داروهای خوراکی ۲ ساعت قبل یا بعد.","In about 3 tablespoons of water. Other oral drugs 2 h before or after.",[67],{"source":32,"section":68},"2.3",{"id":70,"disease":45,"label":71,"population":74,"type":53,"unit":28,"dose":76,"refs":77,"notes":79},"maint",{"fa":72,"en":73},"هیپرکالمی — نگهدارنده ۱۰ g یک بار در روز","Hyperkalaemia — maintenance 10 g once daily",{"minAge":75},{"value":51,"unit":52},{"perDose":38,"dosesPerDay":5},[78],{"source":32,"section":58},[80],{"text":81,"refs":84},{"fa":82,"en":83},"بر اساس پتاسیم هر یک هفته یا بیشتر ۵ g تنظیم. همودیالیز: فقط روزهای غیر دیالیز، شروع ۵ g (پتاسیم بالای ۶٫۵: ۱۰ g).","Adjust by 5 g at intervals of ≥1 week by potassium. Haemodialysis: non-dialysis days only, start 5 g (K >6.5: 10 g).",[85,86],{"source":32,"section":58},{"source":32,"section":87},"2.2",[],[],[],[],[],{"status":94,"reviewer":95,"date":95},"unverified",null,[97,102],{"regimen":44,"formulation":35,"input":98,"expect":101},{"ageYears":99,"weightKg":100},60,70,{"perDose":38,"tabletsPerDoseRounded":5},{"regimen":70,"formulation":35,"input":103,"expect":104},{"ageYears":99,"weightKg":100},{"perDose":38,"tabletsPerDoseRounded":5},[106],"V03AE10",{"status":108,"refs":109},"not-found",[110],{"source":111,"section":112,"url":113},"darooyab-generic","search","https:\u002F\u002Fwww.darooyab.ir\u002FSearch?q=Sodium%20zirconium%20cyclosilicate",[115,119,123,127],{"kind":116,"url":117,"label":118},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=207078","NDA207078",{"kind":120,"url":121,"label":122},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=90bf8e28-748d-4e4b-a19f-9cf483370eff","FDA Lokelma",{"kind":124,"url":125,"label":126},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa618035.html","Sodium Zirconium Cyclosilicate",{"kind":128,"url":129,"label":106},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=V03AE10",{"pregnancy":131,"lactation":140,"pediatric":148,"geriatric":157},{"level":132,"text":133,"quote":136,"refs":137},"ok",{"fa":134,"en":135},"برچسب: جذب سیستمیک ناچیز؛ مواجهه جنین انتظار نمی‌رود.","Label: minimal systemic absorption; fetal exposure not expected.","Risk Summary LOKELMA is not absorbed systemically following oral administration and maternal use is not expected to result in fetal exposure to the drug.",[138],{"source":32,"section":139},"8.1",{"level":132,"text":141,"quote":144,"refs":145},{"fa":142,"en":143},"برچسب: مواجهه شیرخوار انتظار نمی‌رود.","Label: infant exposure not expected.","Risk Summary LOKELMA is not absorbed systemically following oral administration, and breastfeeding is not expected to result in exposure of the child to LOKELMA.",[146],{"source":32,"section":147},"8.2",{"level":149,"text":150,"quote":153,"refs":154},"not-established",{"fa":151,"en":152},"برچسب: ایمنی و اثربخشی در کودکان ثابت نشده است.","Label: safety and effectiveness in children have not been established.","Safety and effectiveness in pediatric patients have not been established.",[155],{"source":32,"section":156},"8.4",{"level":132,"text":158,"quote":161,"refs":162},{"fa":159,"en":160},"برچسب: در سالمندان تفاوت یا تنظیم دوز خاصی ذکر نشده.","Label: no specific difference or dose adjustment stated for older adults.","No overall differences in safety or effectiveness were observed between these patients and younger patients.",[163],{"source":32,"section":164},"8.5",{"kind":166,"refs":167,"id":118},"NDA",[168],{"source":32,"section":169},"SPL approval \u002F marketing category",1792111468428]