[{"data":1,"prerenderedAt":143},["ShallowReactive",2],{"drug-sevoflurane":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":21,"regimens":34,"contraindications":51,"warnings":61,"renal":69,"monitoring":70,"interactions":71,"review":72,"examples":75,"atc":76,"iran":78,"usApproval":90,"links":96,"populations":109},"sevoflurane",1,{"fa":7,"en":8},"سووفلوران","Sevoflurane","nervous-system",{"fa":11,"en":12},"هوشبر استنشاقی هالوژنه","Halogenated inhalational anaesthetic",[14],{"name":15,"market":16},"Ultane","US",[18,19,20,7],"ultane","sevorane","سووران",[22],{"id":23,"form":24,"route":25,"label":26,"concentration":27,"markets":29,"refs":30},"liq","solution","inhaled","Volatile liquid for vaporizer (100%)",{"amount":5,"unit":28,"perUnit":28},"application",[16],[31],{"source":32,"section":33},"fda-sevoflurane","Description",[35],{"id":36,"disease":37,"label":38,"population":41,"type":42,"unit":43,"dose":44,"refs":48},"ga","general-anesthesia",{"fa":39,"en":40},"القا و نگهداری بیهوشی عمومی (بزرگسال و کودک) — غلظت دمی با ویپوریزر اختصاصی، فردی","Induction and maintenance of general anaesthesia (adults and children) — inspired concentration via a dedicated vaporizer, individualised",{},"notCalculated","mg",{"reason":45},{"fa":46,"en":47},"دوز به‌صورت درصد غلظت دمی\u002FMAC و بر اساس پاسخ بیمار تنظیم می‌شود؛ عدد قابل محاسبه با وزن ندارد. فقط با ویپوریزر کالیبره‌شده برای سووفلوران.","Dosed as inspired concentration\u002FMAC and titrated to response; no weight-based number. Only with a vaporizer calibrated for sevoflurane.",[49],{"source":32,"section":50},"Dosage and Administration",[52],{"id":53,"severity":54,"text":55,"refs":58},"ci","block",{"fa":56,"en":57},"استعداد ژنتیکی (شناخته یا مشکوک) هیپرترمی بدخیم؛ حساسیت به این دارو یا سایر هوشبرهای هالوژنه.","Known or suspected genetic susceptibility to malignant hyperthermia; sensitivity to this or other halogenated anaesthetics.",[59],{"source":32,"section":60},"Contraindications",[62],{"text":63,"refs":66},{"fa":64,"en":65},"هیپرترمی بدخیم؛ هیپرکالمی حین عمل (به‌ویژه میوپاتی‌ها)؛ طولانی شدن QT؛ آسیب کبد؛ نوروتوکسیسیتی احتمالی در کودک زیر ۳ سال با بیهوشی طولانی.","Malignant hyperthermia; perioperative hyperkalaemia (especially myopathies); QT prolongation; hepatic injury; possible neurotoxicity in children under 3 with prolonged anaesthesia.",[67],{"source":32,"section":68},"Warnings",[],[],[],{"status":73,"reviewer":74,"date":74},"unverified",null,[],[77],"N01AB08",{"status":79,"forms":80,"refs":85},"registered",[81],{"code":82,"en":83,"fa":84},"02548","SEVOFLURAN 250ML FOR INHALATION","سووفلوران ۲۵۰ میلی‌لیتر",[86],{"source":87,"section":88,"url":89},"darooyab-generic","G-2926\u002FSevoflurane","https:\u002F\u002Fwww.darooyab.ir\u002FG-2926\u002FSevoflurane",{"kind":91,"refs":92,"id":95},"ANDA",[93],{"source":32,"section":94},"SPL approval \u002F marketing category","ANDA075895",[97,100,104,107],{"kind":98,"url":99,"label":95},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=075895",{"kind":101,"url":102,"label":103},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=22700993-851a-48aa-941e-1d2b6b04081f","FDA Sevoflurane",{"kind":105,"url":106,"label":77},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=N01AB08",{"kind":108,"url":89,"label":8},"darooyab",{"pregnancy":110,"lactation":119,"pediatric":127,"geriatric":135},{"level":111,"text":112,"quote":115,"refs":116},"caution",{"fa":113,"en":114},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","Risk Summary There are no adequate and well-controlled studies in pregnant women.",[117],{"source":32,"section":118},"Pregnancy",{"level":111,"text":120,"quote":123,"refs":124},{"fa":121,"en":122},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","To minimize infant exposure to sevoflurane or its metabolites, a nursing mother may temporarily pump, and discard breast milk produced during the first 24 hours after administration of sevoflurane.",[125],{"source":32,"section":126},"Nursing Mothers",{"level":111,"text":128,"quote":131,"refs":132},{"fa":129,"en":130},"برچسب برای کودکان شرط، محدودیت سنی یا نکته دارد؛ جمله برچسب در زیر آمده است.","The label has conditions, age limits or notes for children; the label sentence is quoted below.","Induction and maintenance of general anesthesia with sevoflurane have been established in controlled clinical studies in pediatric patients aged 1 to 18 years (see CLINICAL STUDIES , ADVERSE REACTIONS ).",[133],{"source":32,"section":134},"Pediatric Use",{"level":111,"text":136,"quote":139,"refs":140},{"fa":137,"en":138},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","MAC decreases with increasing age.",[141],{"source":32,"section":142},"Geriatric Use",1792444422703]