[{"data":1,"prerenderedAt":234},["ShallowReactive",2],{"drug-rivastigmine":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":20,"regimens":59,"contraindications":89,"warnings":99,"renal":100,"monitoring":101,"interactions":102,"review":103,"examples":106,"atc":112,"iran":114,"links":174,"populations":194,"usApproval":229},"rivastigmine",1,{"fa":7,"en":8},"ریواستیگمین","Rivastigmine","nervous-system",{"fa":11,"en":12},"مهارکننده کولین‌استراز","Cholinesterase inhibitor",[14],{"name":15,"market":16},"Exelon","US",[18,19,7],"exelon","اکسلون",[21,35,43,51],{"id":22,"form":23,"route":24,"label":25,"concentration":26,"markets":30,"refs":31},"cap-1-5","capsule","oral","1.5 mg capsule",{"amount":27,"unit":28,"perUnit":23,"scored":29},1.5,"mg",false,[16],[32],{"source":33,"section":34},"fda-rivastigmine","3",{"id":36,"form":23,"route":24,"label":37,"concentration":38,"markets":40,"refs":41},"cap-3","3 mg capsule",{"amount":39,"unit":28,"perUnit":23,"scored":29},3,[16],[42],{"source":33,"section":34},{"id":44,"form":23,"route":24,"label":45,"concentration":46,"markets":48,"refs":49},"cap-4-5","4.5 mg capsule",{"amount":47,"unit":28,"perUnit":23,"scored":29},4.5,[16],[50],{"source":33,"section":34},{"id":52,"form":23,"route":24,"label":53,"concentration":54,"markets":56,"refs":57},"cap-6","6 mg capsule",{"amount":55,"unit":28,"perUnit":23,"scored":29},6,[16],[58],{"source":33,"section":34},[60],{"id":61,"disease":62,"label":63,"population":66,"type":70,"unit":28,"dose":71,"refs":73,"limits":76,"notes":80},"ad","alzheimers",{"fa":64,"en":65},"آلزایمر — شروع ۱٫۵ mg دو بار در روز","Alzheimer’s — start 1.5 mg twice daily",{"minAge":67},{"value":68,"unit":69},18,"year","fixed",{"perDose":27,"dosesPerDay":72},2,[74],{"source":33,"section":75},"2.1",{"maxPerDay":77,"refs":78},12,[79],{"source":33,"section":75},[81],{"text":82,"refs":85},{"fa":83,"en":84},"هر حداقل ۲ هفته: ۳ ← ۴٫۵ ← ۶ mg دو بار. اگر بیش از ۳ روز قطع شد از ۱٫۵ mg دوباره. با غذا.","At least every 2 weeks: 3 → 4.5 → 6 mg twice daily. If interrupted >3 days restart at 1.5 mg. With food.",[86,87],{"source":33,"section":75},{"source":33,"section":88},"2.3",[90],{"id":91,"severity":92,"text":93,"refs":96},"ci","block",{"fa":94,"en":95},"حساسیت به ریواستیگمین یا کاربامات‌ها؛ سابقه واکنش محل چسب.","Hypersensitivity to rivastigmine or carbamates; previous patch-site reaction.",[97],{"source":33,"section":98},"4",[],[],[],[],{"status":104,"reviewer":105,"date":105},"unverified",null,[107],{"regimen":61,"formulation":22,"input":108,"expect":111},{"ageYears":109,"weightKg":110},75,65,{"perDose":27,"tabletsPerDoseRounded":5},[113],"N06DA03",{"status":115,"forms":116,"refs":169},"registered",[117,121,125,129,133,137,141,145,149,153,157,161,165],{"code":118,"en":119,"fa":120},"01998","RIVASTIGMINE 1.5MG CAP","کپسول ریواستیگمین ۱٫۵ میلی‌گرم",{"code":122,"en":123,"fa":124},"01902","RIVASTIGMINE 1.5MG TAB","قرص ریواستیگمین ۱٫۵ میلی‌گرم",{"code":126,"en":127,"fa":128},"15859","RIVASTIGMINE 18MG\u002F10CM2 PATCH","پچ پوستی ریواستیگمین ۱۸ میلی‌گرم \u002F ۱۰ سانتی‌متر ۲",{"code":130,"en":131,"fa":132},"09689","RIVASTIGMINE 2MG\u002F100ML SYRUP","شربت ریواستیگمین ۲ میلی‌گرم \u002F ۱۰۰ میلی‌لیتر",{"code":134,"en":135,"fa":136},"01999","RIVASTIGMINE 3MG CAP","کپسول ریواستیگمین ۳ میلی‌گرم",{"code":138,"en":139,"fa":140},"01903","RIVASTIGMINE 3MG TAB","قرص ریواستیگمین ۳ میلی‌گرم",{"code":142,"en":143,"fa":144},"02000","RIVASTIGMINE 4.5MG CAP","کپسول ریواستیگمین ۴٫۵ میلی‌گرم",{"code":146,"en":147,"fa":148},"01904","RIVASTIGMINE 4.5MG TAB","قرص ریواستیگمین ۴٫۵ میلی‌گرم",{"code":150,"en":151,"fa":152},"19832","RIVASTIGMINE 4.6MG\u002F24H PATCH","پچ پوستی ریواستیگمین ۴٫۶ میلی‌گرم \u002F ۲۴ H",{"code":154,"en":155,"fa":156},"02738","RIVASTIGMINE 6MG CAP","کپسول ریواستیگمین ۶ میلی‌گرم",{"code":158,"en":159,"fa":160},"01931","RIVASTIGMINE 6MG TAB","قرص ریواستیگمین ۶ میلی‌گرم",{"code":162,"en":163,"fa":164},"15858","RIVASTIGMINE 9MG\u002F5CM2 PATCH","پچ پوستی ریواستیگمین ۹ میلی‌گرم \u002F ۵ سانتی‌متر ۲",{"code":166,"en":167,"fa":168},"52413","RIVASTIGMINE (AS HYDROGEN TARTRATE) SOLUTION ORAL 2 mg\u002F1mL 120 mL","محلول خوراکی ریواستیگمین (معادل هیدروژن تارتارات) ۲ میلی‌گرم \u002F ۱ میلی‌لیتر ۱۲۰ میلی‌لیتر",[170],{"source":171,"section":172,"url":173},"darooyab-generic","G-3054\u002FRivastigmine","https:\u002F\u002Fwww.darooyab.ir\u002FG-3054\u002FRivastigmine",[175,179,183,186,189,192],{"kind":176,"url":177,"label":178},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=204572","ANDA204572",{"kind":180,"url":181,"label":182},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=c246a0e5-1e77-41ee-a7b3-384f21f2f2e0","FDA Rivastigmine caps.",{"kind":184,"url":185,"label":8},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa602009.html",{"kind":184,"url":187,"label":188},"https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa607078.html","Rivastigmine Transdermal Patch",{"kind":190,"url":191,"label":113},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=N06DA03",{"kind":193,"url":173,"label":8},"darooyab",{"pregnancy":195,"lactation":204,"pediatric":212,"geriatric":221},{"level":196,"text":197,"quote":200,"refs":201},"caution",{"fa":198,"en":199},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","Risk Summary There are no adequate data on the developmental risks associated with the use of rivastigmine tartrate in pregnant women.",[202],{"source":33,"section":203},"8.1",{"level":196,"text":205,"quote":208,"refs":209},{"fa":206,"en":207},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","Risk Summary There are no data on the presence of rivastigmine in human milk, the effects on the breastfed infant, or the effects of rivastigmine on milk production.",[210],{"source":33,"section":211},"8.2",{"level":213,"text":214,"quote":217,"refs":218},"not-established",{"fa":215,"en":216},"برچسب: ایمنی و اثربخشی در کودکان ثابت نشده است.","Label: safety and effectiveness in children have not been established.","Safety and effectiveness in pediatric patients have not been established.",[219],{"source":33,"section":220},"8.4",{"level":196,"text":222,"quote":225,"refs":226},{"fa":223,"en":224},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","Of the total number of patients in clinical studies of rivastigmine tartrate, 86% were 65 years and older while 46% were 75 years and older.",[227],{"source":33,"section":228},"8.5",{"kind":230,"refs":231,"id":178},"ANDA",[232],{"source":33,"section":233},"SPL approval \u002F marketing category",1792092044170]