[{"data":1,"prerenderedAt":166},["ShallowReactive",2],{"drug-riluzole":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":19,"regimens":34,"contraindications":57,"warnings":67,"renal":75,"monitoring":76,"interactions":77,"review":78,"examples":81,"atc":87,"iran":89,"usApproval":101,"links":107,"populations":123},"riluzole",1,{"fa":7,"en":8},"ریلوزول","Riluzole","nervous-system",{"fa":11,"en":12},"مهارکننده گلوتامات","Glutamate inhibitor",[14],{"name":15,"market":16},"Rilutek","US",[18,7],"rilutek",[20],{"id":21,"form":22,"route":23,"label":24,"concentration":25,"markets":29,"refs":30},"tab-50","tablet","oral","50 mg tablet",{"amount":26,"unit":27,"perUnit":22,"scored":28},50,"mg",false,[16],[31],{"source":32,"section":33},"fda-riluzole","3",[35],{"id":36,"disease":36,"label":37,"population":40,"type":44,"unit":27,"dose":45,"refs":47,"notes":50},"als",{"fa":38,"en":39},"ALS — ۵۰ mg دو بار در روز، ۱ ساعت قبل یا ۲ ساعت بعد از غذا","ALS — 50 mg twice daily, 1 h before or 2 h after a meal",{"minAge":41},{"value":42,"unit":43},18,"year","fixed",{"perDose":26,"dosesPerDay":46},2,[48],{"source":32,"section":49},"2",[51],{"text":52,"refs":55},{"fa":53,"en":54},"آنزیم‌های کبد قبل و حین درمان.","Check aminotransferases before and during treatment.",[56],{"source":32,"section":49},[58],{"id":59,"severity":60,"text":61,"refs":64},"hyper","block",{"fa":62,"en":63},"سابقه حساسیت شدید به ریلوزول (آنافیلاکسی رخ داده).","History of severe hypersensitivity to riluzole (anaphylaxis has occurred).",[65],{"source":32,"section":66},"4",[68],{"text":69,"refs":72},{"fa":70,"en":71},"آسیب کبدی (ALT بالای ۵ برابر: توصیه نمی‌شود)؛ نوتروپنی (گزارش تب)؛ بیماری بینابینی ریه.","Hepatic injury (not recommended if ALT >5× ULN); neutropenia (report fever); interstitial lung disease.",[73],{"source":32,"section":74},"5",[],[],[],{"status":79,"reviewer":80,"date":80},"unverified",null,[82],{"regimen":36,"formulation":21,"input":83,"expect":86},{"ageYears":84,"weightKg":85},60,70,{"perDose":26,"tabletsPerDoseRounded":5},[88],"N07XX02",{"status":90,"forms":91,"refs":96},"registered",[92],{"code":93,"en":94,"fa":95},"01921","RILUZOLE 50MG TAB","قرص ریلوزول ۵۰ میلی‌گرم",[97],{"source":98,"section":99,"url":100},"darooyab-generic","G-4181\u002FRiluzole","https:\u002F\u002Fwww.darooyab.ir\u002FG-4181\u002FRiluzole",{"kind":102,"refs":103,"id":106},"ANDA",[104],{"source":32,"section":105},"SPL approval \u002F marketing category","ANDA206045",[108,111,115,118,121],{"kind":109,"url":110,"label":106},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=206045",{"kind":112,"url":113,"label":114},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=ccead445-970c-46a1-9532-2848cc2aa3b6","FDA Riluzole",{"kind":116,"url":117,"label":8},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa696013.html",{"kind":119,"url":120,"label":88},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=N07XX02",{"kind":122,"url":100,"label":8},"darooyab",{"pregnancy":124,"lactation":133,"pediatric":141,"geriatric":150,"reproductive":158},{"level":125,"text":126,"quote":129,"refs":130},"caution",{"fa":127,"en":128},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","Risk Summary There are no studies of riluzole in pregnant women, and case reports have been inadequate to inform the drug-associated risk.",[131],{"source":32,"section":132},"8.1",{"level":125,"text":134,"quote":137,"refs":138},{"fa":135,"en":136},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","Risk Summary It is not known if riluzole is excreted in human milk.",[139],{"source":32,"section":140},"8.2",{"level":142,"text":143,"quote":146,"refs":147},"not-established",{"fa":144,"en":145},"برچسب: ایمنی و اثربخشی در کودکان ثابت نشده است.","Label: safety and effectiveness in children have not been established.","Safety and effectiveness of riluzole tablets in pediatric patients have not been established.",[148],{"source":32,"section":149},"8.4",{"level":125,"text":151,"quote":154,"refs":155},{"fa":152,"en":153},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","In clinical studies of riluzole tablets, 30% of patients were 65 years and over.",[156],{"source":32,"section":157},"8.5",{"level":125,"text":159,"quote":162,"refs":163},{"fa":160,"en":161},"برچسب نکته‌ای درباره بارداری، پیشگیری یا باروری زنان و مردان دارد.","Label has advice on pregnancy testing, contraception or fertility for females and males.","In rats, oral administration of riluzole resulted in decreased fertility indices and increases in embryolethality [see Nonclinical Toxicology (13.1)].",[164],{"source":32,"section":165},"8.3",1792156193999]