[{"data":1,"prerenderedAt":199},["ShallowReactive",2],{"drug-quinine":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":20,"regimens":35,"contraindications":66,"warnings":76,"renal":84,"monitoring":85,"interactions":86,"review":87,"examples":90,"atc":97,"iran":99,"links":142,"populations":160,"usApproval":194},"quinine",1,{"fa":7,"en":8},"کینین (خوراکی)","Quinine sulfate (oral)","antiparasitic",{"fa":11,"en":12},"ضدمالاریا","Antimalarial",[14],{"name":15,"market":16},"Qualaquin","US",[18,19,4],"qualaquin","کینین",[21],{"id":22,"form":23,"route":24,"label":25,"concentration":26,"markets":30,"refs":31},"cap-324","capsule","oral","324 mg capsule",{"amount":27,"unit":28,"perUnit":23,"scored":29},324,"mg",false,[16],[32],{"source":33,"section":34},"fda-quinine","3",[36],{"id":37,"disease":38,"label":39,"population":42,"type":46,"unit":28,"dose":47,"refs":50,"durationDays":53,"notes":55},"treat","malaria",{"fa":40,"en":41},"مالاریای فالسیپاروم بدون عارضه — ۶۴۸ mg هر ۸ ساعت، ۷ روز (۱۶ سال به بالا)","Uncomplicated P. falciparum malaria — 648 mg every 8 h for 7 days (≥16 y)",{"minAge":43},{"value":44,"unit":45},16,"year","fixed",{"perDose":48,"dosesPerDay":49},648,3,[51],{"source":33,"section":52},"2.1",{"min":54,"max":54},7,[56],{"text":57,"refs":60},{"fa":58,"en":59},"همراه غذا. نارسایی شدید مزمن کلیه: یک دوز بارگذاری ۶۴۸ mg، سپس ۳۲۴ mg هر ۱۲ ساعت. در نارسایی شدید کبد مصرف نشود.","With food. Severe chronic renal impairment: one 648 mg loading dose, then 324 mg every 12 h. Not for severe hepatic impairment.",[61,62,64],{"source":33,"section":52},{"source":33,"section":63},"2.2",{"source":33,"section":65},"2.3",[67],{"id":68,"severity":69,"text":70,"refs":73},"ci","block",{"fa":71,"en":72},"QT طولانی، کمبود G6PD، میاستنی گراویس، نوریت اپتیک، حساسیت به کینین\u002Fمفلوکین\u002Fکینیدین.","Prolonged QT, G6PD deficiency, myasthenia gravis, optic neuritis, hypersensitivity to quinine\u002Fmefloquine\u002Fquinidine.",[74],{"source":33,"section":75},"4",[77],{"text":78,"refs":81},{"fa":79,"en":80},"هشدار جعبه‌ای: برای گرفتگی شبانه پا مصرف نشود — واکنش‌های خونی کشنده (ترومبوسیتوپنی، HUS\u002FTTP).","Boxed warning: not for nocturnal leg cramps — life-threatening haematologic reactions (thrombocytopenia, HUS\u002FTTP).",[82],{"source":33,"section":83},"Boxed Warning",[],[],[],{"status":88,"reviewer":89,"date":89},"unverified",null,[91],{"regimen":37,"formulation":22,"input":92,"expect":95},{"ageYears":93,"weightKg":94},30,70,{"perDose":48,"tabletsPerDoseRounded":96},2,[98],"P01BC01",{"status":100,"forms":101,"refs":137},"registered",[102,106,110,114,118,122,126,130,134],{"code":103,"en":104,"fa":105},"01089","QUININE 100MG TAB","قرص کینین ۱۰۰ میلی‌گرم",{"code":107,"en":108,"fa":109},"06966","QUININE 200MG TAB","قرص کینین ۲۰۰ میلی‌گرم",{"code":111,"en":112,"fa":113},"01090","QUININE 250MG TAB","قرص کینین ۲۵۰ میلی‌گرم",{"code":115,"en":116,"fa":117},"01091","QUININE 250MG\u002F1ML AMP","آمپول کینین ۲۵۰ میلی‌گرم \u002F ۱ میلی‌لیتر",{"code":119,"en":120,"fa":121},"01756","QUININE 300MG\u002FML AMP","آمپول کینین ۳۰۰ میلی‌گرم \u002F میلی‌لیتر",{"code":123,"en":124,"fa":125},"14575","QUININE 600MG\u002FML AMP","آمپول کینین ۶۰۰ میلی‌گرم \u002F میلی‌لیتر",{"code":127,"en":128,"fa":129},"02042","QUININE HCL 100MG CAP","کپسول کینین هیدروکلراید ۱۰۰ میلی‌گرم",{"code":131,"en":132,"fa":133},"06724","QUININE SULPHATE 300MG TAB","قرص کینین سولفات ۳۰۰ میلی‌گرم",{"code":135,"en":136,"fa":133},"51949","QUININE SULFATE TABLET ORAL 300 mg",[138],{"source":139,"section":140,"url":141},"darooyab-generic","G-849\u002FQuinine","https:\u002F\u002Fwww.darooyab.ir\u002FG-849\u002FQuinine",[143,147,151,155,158],{"kind":144,"url":145,"label":146},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=203112","ANDA203112",{"kind":148,"url":149,"label":150},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=1f32f05c-a215-40be-b951-e41a7b54a8a0","FDA Quinine sulfate",{"kind":152,"url":153,"label":154},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa682322.html","Quinine",{"kind":156,"url":157,"label":98},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=P01BC01",{"kind":159,"url":141,"label":154},"darooyab",{"pregnancy":161,"lactation":170,"pediatric":178,"geriatric":186},{"level":162,"text":163,"quote":166,"refs":167},"caution",{"fa":164,"en":165},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","Pregnancy Category C There are extensive published data but few well-controlled studies of quinine sulfate in pregnant women.",[168],{"source":33,"section":169},"8.1",{"level":162,"text":171,"quote":174,"refs":175},{"fa":172,"en":173},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","Caution should be exercised when administered to a nursing woman.",[176],{"source":33,"section":177},"8.3",{"level":162,"text":179,"quote":182,"refs":183},{"fa":180,"en":181},"برچسب برای کودکان شرط، محدودیت سنی یا نکته دارد؛ جمله برچسب در زیر آمده است.","The label has conditions, age limits or notes for children; the label sentence is quoted below.","The safety and efficacy of quinine sulfate in pediatric patients under the age of 16 has not been established.",[184],{"source":33,"section":185},"8.4",{"level":162,"text":187,"quote":190,"refs":191},{"fa":188,"en":189},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","Clinical studies of quinine sulfate did not include sufficient numbers of subjects aged 65 and over to determine whether they respond to treatment differently from younger subjects.",[192],{"source":33,"section":193},"8.5",{"kind":195,"refs":196,"id":146},"ANDA",[197],{"source":33,"section":198},"SPL approval \u002F marketing category",1792106599362]