[{"data":1,"prerenderedAt":162},["ShallowReactive",2],{"drug-pyrimethamine":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":20,"regimens":35,"contraindications":63,"warnings":73,"renal":81,"monitoring":82,"interactions":83,"review":84,"examples":87,"atc":94,"iran":96,"usApproval":108,"links":114,"populations":127},"pyrimethamine",1,{"fa":7,"en":8},"پیریمتامین","Pyrimethamine","antiparasitic",{"fa":11,"en":12},"آنتاگونیست اسید فولیک (ضدانگل)","Folic acid antagonist (antiparasitic)",[14],{"name":15,"market":16},"Daraprim","US",[18,19,7],"daraprim","داراپریم",[21],{"id":22,"form":23,"route":24,"label":25,"concentration":26,"markets":30,"refs":31},"tab-25","tablet","oral","25 mg tablet (scored)",{"amount":27,"unit":28,"perUnit":23,"scored":29},25,"mg",true,[16],[32],{"source":33,"section":34},"fda-daraprim","How Supplied",[36],{"id":37,"disease":38,"label":39,"population":42,"type":46,"unit":28,"dose":47,"refs":50,"durationDays":53,"notes":56},"toxo","toxoplasmosis",{"fa":40,"en":41},"توکسوپلاسموز — بزرگسال شروع ۵۰ تا ۷۵ mg روزانه همراه سولفونامید، ۱ تا ۳ هفته","Toxoplasmosis — adult start 50–75 mg daily with a sulfonamide, 1–3 weeks",{"minAge":43},{"value":44,"unit":45},18,"year","fixed",{"perDose":48,"perDoseMax":49,"dosesPerDay":5},50,75,[51],{"source":33,"section":52},"Dosage and Administration",{"min":54,"max":55},7,21,[57],{"text":58,"refs":61},{"fa":59,"en":60},"همراه ۱ تا ۴ g سولفونامید (مثلاً سولفادیازین) روزانه و اسید فولینیک (لکوورین) در همه بیماران. سپس حدود نصف دوز ۴ تا ۵ هفته. کودک: ۱ mg\u002Fkg روزانه در دو دوز ۲ تا ۴ روز، سپس نصف تا یک ماه.","With 1–4 g of a sulfonamide (e.g. sulfadiazine) daily and folinic acid (leucovorin) in all patients. Then about half the dose for 4–5 weeks. Children: 1 mg\u002Fkg\u002Fday in two doses for 2–4 days, then half for about a month.",[62],{"source":33,"section":52},[64],{"id":65,"severity":66,"text":67,"refs":70},"ci","block",{"fa":68,"en":69},"حساسیت به پیریمتامین؛ کم‌خونی مگالوبلاستیک ناشی از کمبود فولات.","Hypersensitivity to pyrimethamine; megaloblastic anaemia due to folate deficiency.",[71],{"source":33,"section":72},"Contraindications",[74],{"text":75,"refs":78},{"fa":76,"en":77},"دامنه درمانی باریک؛ علائم کمبود فولات — اسید فولینیک ۵ تا ۱۵ mg روزانه؛ CBC دو بار در هفته.","Narrow therapeutic window; folate deficiency — folinic acid 5–15 mg daily; CBC twice weekly.",[79],{"source":33,"section":80},"Warnings",[],[],[],{"status":85,"reviewer":86,"date":86},"unverified",null,[88],{"regimen":37,"formulation":22,"input":89,"expect":92},{"ageYears":90,"weightKg":91},35,70,{"perDose":48,"tabletsPerDoseRounded":93,"upperPerDose":49},2,[95],"P01BD01",{"status":97,"forms":98,"refs":103},"registered",[99],{"code":100,"en":101,"fa":102},"01083","PYRIMETHAMINE 25MG TAB","قرص پیریمتامین ۲۵ میلی‌گرم",[104],{"source":105,"section":106,"url":107},"darooyab-generic","G-847\u002FPyrimethamine","https:\u002F\u002Fwww.darooyab.ir\u002FG-847\u002FPyrimethamine",{"kind":109,"refs":110,"id":113},"NDA",[111],{"source":33,"section":112},"SPL approval \u002F marketing category","NDA008578",[115,118,122,125],{"kind":116,"url":117,"label":113},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=008578",{"kind":119,"url":120,"label":121},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=f634f34b-0952-4dd3-9da3-f84b6ab823de","FDA Daraprim",{"kind":123,"url":124,"label":95},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=P01BD01",{"kind":126,"url":107,"label":8},"darooyab",{"pregnancy":128,"lactation":137,"pediatric":146,"geriatric":154},{"level":129,"text":130,"quote":133,"refs":134},"caution",{"fa":131,"en":132},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","DARAPRIM should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.",[135],{"source":33,"section":136},"Precautions\u002FWarnings – Pregnancy",{"level":138,"text":139,"quote":142,"refs":143},"avoid",{"fa":140,"en":141},"برچسب: شیردهی توصیه نمی‌شود یا باید بین دارو و شیردهی یکی انتخاب شود.","Label: breastfeeding not recommended, or choose between the drug and breastfeeding.","… rimethamine and from concurrent use of a sulfonamide with DARAPRIM for treatment of some patients with toxoplasmosis, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother (see WARNINGS and PRECAUTIONS:",[144],{"source":33,"section":145},"Precautions\u002FWarnings – Nursing Mothers",{"level":129,"text":147,"quote":150,"refs":151},{"fa":148,"en":149},"برچسب برای کودکان شرط، محدودیت سنی یا نکته دارد؛ جمله برچسب در زیر آمده است.","The label has conditions, age limits or notes for children; the label sentence is quoted below.","See DOSAGE AND ADMINISTRATION section.",[152],{"source":33,"section":153},"Precautions\u002FWarnings – Pediatric Use",{"level":129,"text":155,"quote":158,"refs":159},{"fa":156,"en":157},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy.",[160],{"source":33,"section":161},"Precautions\u002FWarnings – Geriatric Use",1792191563488]