[{"data":1,"prerenderedAt":143},["ShallowReactive",2],{"drug-protamine":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":20,"regimens":34,"contraindications":50,"warnings":60,"renal":68,"monitoring":69,"interactions":70,"review":71,"examples":74,"atc":75,"iran":77,"links":97,"populations":111,"usApproval":138},"protamine",1,{"fa":7,"en":8},"پروتامین سولفات","Protamine sulfate","various",{"fa":11,"en":12},"خنثی‌کننده هپارین","Heparin antagonist",[14],{"name":15,"market":16},"Protamine","US",[4,18,19],"پروتامین","خنثی کننده هپارین",[21],{"id":22,"form":23,"route":24,"label":25,"concentration":26,"markets":29,"refs":30},"vial-10","injection","iv","10 mg\u002FmL (50 mg\u002F5 mL; 250 mg\u002F25 mL)",{"amount":27,"unit":28,"perVolumeMl":5},10,"mg",[16],[31],{"source":32,"section":33},"fda-protamine","How Supplied",[35],{"id":36,"disease":37,"label":38,"population":41,"type":42,"unit":28,"dose":43,"refs":47},"heparin","heparin-overdose",{"fa":39,"en":40},"خنثی‌سازی هپارین — ۱ mg برای هر ۱۰۰ واحد هپارین (حداکثر ۵۰ mg در هر تزریق)","Heparin neutralisation — 1 mg per 100 units heparin (max 50 mg per injection)",{},"notCalculated",{"reason":44},{"fa":45,"en":46},"برچسب: هر ۱ mg پروتامین دست‌کم ۱۰۰ واحد هپارین را خنثی می‌کند. وریدی بسیار آهسته در ۱۰ دقیقه، هر بار حداکثر ۵۰ mg. چون هپارین سریع از خون پاک می‌شود، دوز با گذشت زمان کم می‌شود (مثلاً ۳۰ دقیقه پس از هپارین، نصف دوز). دوز با تست‌های انعقادی تنظیم شود.","Label: each mg neutralises at least 100 USP heparin units. Very slow IV over 10 min, no more than 50 mg per dose. Because heparin clears quickly, the dose falls with time (e.g. half the dose 30 min after heparin). Guide by coagulation tests.",[48],{"source":32,"section":49},"Dosage and Administration",[51],{"id":52,"severity":53,"text":54,"refs":57},"ci","block",{"fa":55,"en":56},"سابقه عدم تحمل پروتامین.","Previous intolerance to protamine.",[58],{"source":32,"section":59},"Contraindications",[61],{"text":62,"refs":65},{"fa":63,"en":64},"تزریق سریع: افت شدید فشار و واکنش آنافیلاکتوئید؛ امکانات درمان شوک آماده باشد. پس از جراحی قلب احتمال بازگشت خونریزی.","Rapid injection: severe hypotension and anaphylactoid reactions; shock treatment must be available. Rebound bleeding possible after cardiac surgery.",[66],{"source":32,"section":67},"Warnings",[],[],[],{"status":72,"reviewer":73,"date":73},"unverified",null,[],[76],"V03AB14",{"status":78,"forms":79,"refs":92},"registered",[80,84,88],{"code":81,"en":82,"fa":83},"01073","PROTAMINE SULFATE 1000UAH\u002FML 10ML VIAL","ویال پروتامین سولفات ۱۰۰۰ اواه \u002F میلی‌لیتر ۱۰ میلی‌لیتر",{"code":85,"en":86,"fa":87},"01655","PROTAMINE SULFATE 1000UAH\u002FML 5ML VIAL","ویال پروتامین سولفات ۱۰۰۰ اواه \u002F میلی‌لیتر ۵ میلی‌لیتر",{"code":89,"en":90,"fa":91},"21774","PROTAMINE50MG 5ML VIAL","ویال پروتامین ۵۰ میلی‌گرم ۵ میلی‌لیتر",[93],{"source":94,"section":95,"url":96},"darooyab-generic","G-1976\u002FProtamine","https:\u002F\u002Fwww.darooyab.ir\u002FG-1976\u002FProtamine",[98,102,106,109],{"kind":99,"url":100,"label":101},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=089454","ANDA089454",{"kind":103,"url":104,"label":105},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=c76876da-b9a8-45d0-9278-7df3288d3a06","FDA Protamine",{"kind":107,"url":108,"label":76},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=V03AB14",{"kind":110,"url":96,"label":15},"darooyab",{"pregnancy":112,"lactation":121,"pediatric":129},{"level":113,"text":114,"quote":117,"refs":118},"caution",{"fa":115,"en":116},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","Pregnancy Category C Animal reproduction studies have not been conducted with protamine sulfate.",[119],{"source":32,"section":120},"Pregnancy",{"level":113,"text":122,"quote":125,"refs":126},{"fa":123,"en":124},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","Because many drugs are excreted in human milk, caution should be exercised when protamine sulfate is administered to a nursing woman.",[127],{"source":32,"section":128},"Nursing Mothers",{"level":130,"text":131,"quote":134,"refs":135},"not-established",{"fa":132,"en":133},"برچسب: ایمنی و اثربخشی در کودکان ثابت نشده است.","Label: safety and effectiveness in children have not been established.","Safety and effectiveness in children have not been established.",[136],{"source":32,"section":137},"Pediatric Use",{"kind":139,"refs":140,"id":101},"ANDA",[141],{"source":32,"section":142},"SPL approval \u002F marketing category",1792108435211]