[{"data":1,"prerenderedAt":159},["ShallowReactive",2],{"drug-probenecid":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":16,"formulations":18,"regimens":33,"contraindications":61,"warnings":71,"renal":79,"monitoring":88,"interactions":89,"review":90,"examples":93,"atc":100,"iran":102,"usApproval":118,"links":124,"populations":140},"probenecid",1,{"fa":7,"en":8},"پروبنسید","Probenecid","musculoskeletal",{"fa":11,"en":12},"اوریکوزوریک","Uricosuric",[14],{"name":8,"market":15},"US",[17,7,4],"benemid",[19],{"id":20,"form":21,"route":22,"label":23,"concentration":24,"markets":28,"refs":29},"tab-500","tablet","oral","500 mg tablet (scored)",{"amount":25,"unit":26,"perUnit":21,"scored":27},500,"mg",true,[15],[30],{"source":31,"section":32},"fda-probenecid","How Supplied",[34],{"id":35,"disease":35,"label":36,"population":39,"type":43,"unit":26,"dose":44,"refs":47,"limits":50,"notes":54},"gout",{"fa":37,"en":38},"هیپراوریسمی نقرس (بین حملات) — ۲۵۰ mg دو بار یک هفته، سپس ۵۰۰ mg دو بار","Hyperuricaemia of gout (between attacks) — 250 mg twice daily for one week, then 500 mg twice daily",{"minAge":40},{"value":41,"unit":42},18,"year","fixed",{"perDose":45,"perDoseMax":25,"dosesPerDay":46},250,2,[48],{"source":31,"section":49},"Dosage and Administration",{"maxPerDay":51,"refs":52},2000,[53],{"source":31,"section":49},[55],{"text":56,"refs":59},{"fa":57,"en":58},"تا حمله حاد فروکش نکرده شروع نشود. در صورت نیاز هر ۴ هفته ۵۰۰ mg\u002Fروز افزایش (معمولاً تا ۲۰۰۰ mg\u002Fروز). مایعات فراوان.","Do not start until an acute attack subsides. If needed, +500 mg\u002Fday every 4 weeks (usually up to 2000 mg\u002Fday). Plenty of fluids.",[60],{"source":31,"section":49},[62],{"id":63,"severity":64,"text":65,"refs":68},"ci","block",{"fa":66,"en":67},"حساسیت؛ کودک زیر ۲ سال؛ دیسکرازی خونی یا سنگ اسید اوریک کلیه؛ شروع حین حمله حاد نقرس.","Hypersensitivity; children under 2; blood dyscrasias or uric acid kidney stones; starting during an acute gout attack.",[69],{"source":31,"section":70},"Contraindications",[72],{"text":73,"refs":76},{"fa":74,"en":75},"تشدید حمله نقرس؛ افزایش سطح متوترکسات؛ سالیسیلات‌ها اثر را خنثی می‌کنند.","Gout flare; raises methotrexate levels; salicylates antagonise the effect.",[77],{"source":31,"section":78},"Warnings",[80],{"egfrBelow":81,"severity":82,"text":83,"refs":86},30,"warn",{"fa":84,"en":85},"GFR ۳۰ یا کمتر: احتمالاً بی‌اثر.","GFR ≤30: may be ineffective.",[87],{"source":31,"section":49},[],[],{"status":91,"reviewer":92,"date":92},"unverified",null,[94],{"regimen":35,"formulation":20,"input":95,"expect":98},{"ageYears":96,"weightKg":97},55,85,{"perDose":45,"tabletsPerDoseRounded":99,"upperPerDose":25},0.5,[101],"M04AB01",{"status":103,"forms":104,"refs":113},"registered",[105,109],{"code":106,"en":107,"fa":108},"10385","PROBENECID 100MG TAB","قرص پروبنسید ۱۰۰ میلی‌گرم",{"code":110,"en":111,"fa":112},"08079","PROBENECID 500MG TAB","قرص پروبنسید ۵۰۰ میلی‌گرم",[114],{"source":115,"section":116,"url":117},"darooyab-generic","G-760\u002FProbenecid","https:\u002F\u002Fwww.darooyab.ir\u002FG-760\u002FProbenecid",{"kind":119,"refs":120,"id":123},"ANDA",[121],{"source":31,"section":122},"SPL approval \u002F marketing category","ANDA217020",[125,128,132,135,138],{"kind":126,"url":127,"label":123},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=217020",{"kind":129,"url":130,"label":131},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=f2375d90-4132-4fb6-aee7-c4f9d11e98d5","FDA Probenecid",{"kind":133,"url":134,"label":8},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa682395.html",{"kind":136,"url":137,"label":101},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=M04AB01",{"kind":139,"url":117,"label":8},"darooyab",{"pediatric":141,"pregnancy":150},{"level":142,"text":143,"quote":146,"refs":147},"contraindicated",{"fa":144,"en":145},"برچسب: در کودکان زیر سن مشخص منع مصرف دارد.","Label: contraindicated in children below a stated age.","Children under 2 years of age.",[148],{"source":31,"section":149},"CONTRAINDICATIONS",{"level":151,"quote":152,"text":153,"refs":156},"caution","مصرف در بارداری پروبنسید گروه C در شرايط خاص و نظارت ويژه پزشك قابل استفاده است:",{"fa":154,"en":155},"دارویاب: گروه C — فقط اگر فایده بیشتر از خطر باشد.","Darooyab: category C — only if benefit outweighs risk.",[157],{"source":115,"section":158,"url":117},"G-760\u002FProbenecid — مصرف در بارداری",1792191562596]