[{"data":1,"prerenderedAt":193},["ShallowReactive",2],{"drug-prasugrel":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":19,"regimens":42,"contraindications":85,"warnings":95,"renal":103,"monitoring":104,"interactions":105,"review":106,"examples":109,"atc":118,"iran":120,"links":136,"populations":153,"usApproval":188},"prasugrel",1,{"fa":7,"en":8},"پراسوگرل","Prasugrel","blood",{"fa":11,"en":12},"مهارکننده P2Y12 (ضدپلاکت)","P2Y12 inhibitor (antiplatelet)",[14],{"name":15,"market":16},"Effient","US",[18,7],"effient",[20,34],{"id":21,"form":22,"route":23,"label":24,"concentration":25,"markets":29,"refs":30},"tab-5","tablet","oral","5 mg tablet",{"amount":26,"unit":27,"perUnit":22,"scored":28},5,"mg",false,[16],[31],{"source":32,"section":33},"fda-prasugrel","3",{"id":35,"form":22,"route":23,"label":36,"concentration":37,"markets":39,"refs":40},"tab-10","10 mg tablet",{"amount":38,"unit":27,"perUnit":22,"scored":28},10,[16],[41],{"source":32,"section":33},[43,68],{"id":44,"disease":45,"label":46,"population":49,"type":54,"unit":27,"dose":55,"refs":56,"notes":59},"acs","acute-coronary-syndrome",{"fa":47,"en":48},"سندرم حاد کرونری با PCI — ۱۰ mg روزانه (پس از بارگذاری ۶۰ mg)","ACS managed with PCI — 10 mg daily (after a 60 mg load)",{"minAge":50,"minWeightKg":53},{"value":51,"unit":52},18,"year",60,"fixed",{"perDose":38,"dosesPerDay":5},[57],{"source":32,"section":58},"2",[60],{"text":61,"refs":64},{"fa":62,"en":63},"شروع با دوز بارگذاری ۶۰ mg یک‌جا، سپس روزانه. همراه آسپرین ۷۵ تا ۳۲۵ mg روزانه. ۷۵ سال به بالا معمولاً توصیه نمی‌شود.","Start with a single 60 mg loading dose, then daily. With aspirin 75–325 mg daily. Generally not recommended at ≥75 y.",[65,66],{"source":32,"section":58},{"source":32,"section":67},"5",{"id":69,"disease":45,"label":70,"population":73,"type":54,"unit":27,"dose":76,"refs":77,"notes":79},"acs-low",{"fa":71,"en":72},"وزن زیر ۶۰ kg — ۵ mg روزانه (پس از بارگذاری ۶۰ mg)","Weight \u003C60 kg — 5 mg daily (after a 60 mg load)",{"minAge":74,"maxWeightKg":75},{"value":51,"unit":52},59.99,{"perDose":26,"dosesPerDay":5},[78],{"source":32,"section":58},[80],{"text":81,"refs":82},{"fa":62,"en":63},[83,84],{"source":32,"section":58},{"source":32,"section":67},[86],{"id":87,"severity":88,"text":89,"refs":92},"bleed","block",{"fa":90,"en":91},"خونریزی فعال پاتولوژیک؛ سابقه TIA یا سکته مغزی؛ حساسیت.","Active pathological bleeding; prior TIA or stroke; hypersensitivity.",[93],{"source":32,"section":94},"4",[96],{"text":97,"refs":100},{"fa":98,"en":99},"هشدار جعبه‌ای: خونریزی شدید و گاه کشنده. در ≥۷۵ سال معمولاً توصیه نمی‌شود. ۷ روز پیش از جراحی قطع شود.","Boxed warning: significant, sometimes fatal bleeding. Generally not recommended at ≥75 y. Stop 7 days before surgery.",[101],{"source":32,"section":102},"Boxed Warning",[],[],[],{"status":107,"reviewer":108,"date":108},"unverified",null,[110,114],{"regimen":44,"formulation":35,"input":111,"expect":113},{"ageYears":53,"weightKg":112},80,{"perDose":38,"tabletsPerDoseRounded":5},{"regimen":69,"formulation":21,"input":115,"expect":117},{"ageYears":53,"weightKg":116},55,{"perDose":26,"tabletsPerDoseRounded":5},[119],"B01AC22",{"status":121,"forms":122,"refs":131},"registered",[123,127],{"code":124,"en":125,"fa":126},"16009","PRASUGREL 10MG TAB","قرص پراسوگرل ۱۰ میلی‌گرم",{"code":128,"en":129,"fa":130},"16010","PRASUGREL 5MG TAB","قرص پراسوگرل ۵ میلی‌گرم",[132],{"source":133,"section":134,"url":135},"darooyab-generic","G-4733\u002FPrasugrel","https:\u002F\u002Fwww.darooyab.ir\u002FG-4733\u002FPrasugrel",[137,141,145,148,151],{"kind":138,"url":139,"label":140},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=205897","ANDA205897",{"kind":142,"url":143,"label":144},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=f51e64e0-f556-65d0-a876-fb709aaeefea","FDA Prasugrel",{"kind":146,"url":147,"label":8},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa609027.html",{"kind":149,"url":150,"label":119},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=B01AC22",{"kind":152,"url":135,"label":8},"darooyab",{"pregnancy":154,"lactation":163,"pediatric":171,"geriatric":180},{"level":155,"text":156,"quote":159,"refs":160},"caution",{"fa":157,"en":158},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","Risk Summary There are no data with prasugrel tablets use in pregnant women to inform a drug-associated risk.",[161],{"source":32,"section":162},"8.1",{"level":155,"text":164,"quote":167,"refs":168},{"fa":165,"en":166},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","Risk Summary There is no information regarding the presence of prasugrel in human milk, the effects on the breastfed infant, or the effects on milk production.",[169],{"source":32,"section":170},"8.2",{"level":172,"text":173,"quote":176,"refs":177},"not-established",{"fa":174,"en":175},"برچسب: ایمنی و اثربخشی در کودکان ثابت نشده است.","Label: safety and effectiveness in children have not been established.","Safety and effectiveness in pediatric patients have not been established.",[178],{"source":32,"section":179},"8.4",{"level":155,"text":181,"quote":184,"refs":185},{"fa":182,"en":183},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","… ory of myocardial infarction) where its effect appears to be greater and its use may be considered [see Warnings and Precautions ( 5.1 ), Clinical Pharmacology ( 12.3 ), and Clinical Studies ( 14 )] .",[186],{"source":32,"section":187},"8.5",{"kind":189,"refs":190,"id":140},"ANDA",[191],{"source":32,"section":192},"SPL approval \u002F marketing category",1792115192762]