[{"data":1,"prerenderedAt":119},["ShallowReactive",2],{"drug-physostigmine":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":20,"regimens":34,"contraindications":67,"warnings":77,"renal":78,"monitoring":79,"interactions":80,"review":81,"examples":84,"atc":85,"iran":87,"links":99,"populations":109},"physostigmine",1,{"fa":7,"en":8},"فیزوستیگمین","Physostigmine","various",{"fa":11,"en":12},"مهارکننده کولین‌استراز (پادزهر)","Cholinesterase inhibitor (antidote)",[14],{"name":15,"market":16},"Anticholium","US",[18,19,7],"anticholium","آنتی کولیوم",[21],{"id":22,"form":23,"route":24,"label":25,"concentration":26,"markets":29,"refs":30},"amp","injection","iv","5 mL ampoule (IM or slow IV)",{"amount":5,"unit":27,"perUnit":28},"application","vial",[16],[31],{"source":32,"section":33},"fda-anticholium","How Supplied",[35,54],{"id":36,"disease":37,"label":38,"population":41,"type":45,"unit":46,"dose":47,"refs":51},"adult","anticholinergic-toxicity",{"fa":39,"en":40},"برگشت اثر مرکزی مسمومیت آنتی‌کولینرژیک — بزرگسال ۰٫۵ تا ۱ mg عضلانی یا وریدی آهسته","Reversal of central anticholinergic toxicity — adult 0.5–1 mg IM or slow IV",{"minAge":42},{"value":43,"unit":44},18,"year","notCalculated","mg",{"reason":48},{"fa":49,"en":50},"وریدی حداکثر ۱ mg\u002Fدقیقه؛ در صورت نیاز هر ۱۰ تا ۳۰ دقیقه تکرار. غلظت آمپول این فرآورده وارداتی در برچسب موجود ذکر نشده؛ حجم از روی بسته محاسبه شود.","IV no faster than 1 mg\u002Fmin; repeat every 10–30 min if needed. Ampoule concentration of this imported product is not stated in the available labeling; compute volume from the package.",[52],{"source":32,"section":53},"Dosage and Administration",{"id":55,"disease":37,"label":56,"population":59,"type":45,"unit":46,"dose":61,"refs":65},"child",{"fa":57,"en":58},"کودک — ۰٫۰۲ mg\u002Fkg عضلانی یا وریدی آهسته (حداکثر ۰٫۵ mg\u002Fدقیقه)؛ تکرار هر ۵ تا ۱۰ دقیقه تا حداکثر ۲ mg","Children — 0.02 mg\u002Fkg IM or slow IV (max 0.5 mg\u002Fmin); repeat every 5–10 min up to 2 mg total",{"maxAge":60},{"value":43,"unit":44},{"reason":62},{"fa":63,"en":64},"تکرار فقط اگر اثرات سمی ادامه دارد و علائم کولینرژیک نیست. اقدامات حمایتی همیشه.","Repeat only while toxic effects persist without cholinergic signs. Always with supportive care.",[66],{"source":32,"section":53},[68],{"id":69,"severity":70,"text":71,"refs":74},"ci","block",{"fa":72,"en":73},"حساسیت؛ آسم؛ گانگرن؛ بیماری کرونر؛ انسداد مکانیکی روده یا ادرار؛ دیستروفی میوتونیک؛ آسیب مغزی بسته؛ پس از شل‌کننده‌های دپلاریزان (سوکسینیل‌کولین).","Hypersensitivity; asthma; gangrene; coronary heart disease; mechanical bowel or urinary obstruction; myotonic dystrophy; closed head injury; after depolarising relaxants (succinylcholine).",[75],{"source":32,"section":76},"Contraindications",[],[],[],[],{"status":82,"reviewer":83,"date":83},"unverified",null,[],[86],"V03AB19",{"status":88,"forms":89,"refs":94},"registered",[90],{"code":91,"en":92,"fa":93},"01638","PHYSOSTIGMINE SAL 2MG\u002F2ML AMP","آمپول فیسوستیگمین سال ۲ میلی‌گرم \u002F ۲ میلی‌لیتر",[95],{"source":96,"section":97,"url":98},"darooyab-generic","G-3051\u002FPhysostigmine","https:\u002F\u002Fwww.darooyab.ir\u002FG-3051\u002FPhysostigmine",[100,104,107],{"kind":101,"url":102,"label":103},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=b90b50e8-c8f1-4f2d-be6e-4d269b8c362c","FDA Anticholium",{"kind":105,"url":106,"label":86},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=V03AB19",{"kind":108,"url":98,"label":8},"darooyab",{"pregnancy":110},{"level":111,"text":112,"quote":115,"refs":116},"caution",{"fa":113,"en":114},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","and breast-feeding Pregnancy: There is no experience with the use of Anticholium ® in pregnant women.",[117],{"source":32,"section":118},"Precautions\u002FWarnings – Pregnancy",1792444417604]