[{"data":1,"prerenderedAt":194},["ShallowReactive",2],{"drug-palonosetron":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":20,"regimens":34,"contraindications":85,"warnings":95,"renal":103,"monitoring":104,"interactions":105,"review":106,"examples":109,"atc":127,"iran":129,"links":136,"populations":154,"usApproval":189},"palonosetron",1,{"fa":7,"en":8},"پالونوسترون","Palonosetron","alimentary-metabolism",{"fa":11,"en":12},"آنتاگونیست 5-HT3 (طولانی‌اثر)","Long-acting 5-HT3 antagonist",[14],{"name":15,"market":16},"Aloxi","US",[18,19,7],"aloxi","آلوکسی",[21],{"id":22,"form":23,"route":24,"label":25,"concentration":26,"markets":29,"refs":30},"vial-0-05","injection","iv","0.05 mg\u002FmL (0.25 mg\u002F5 mL) vial",{"amount":27,"unit":28,"perVolumeMl":5},0.05,"mg",[16],[31],{"source":32,"section":33},"fda-palonosetron","3",[35,51,72],{"id":36,"disease":36,"label":37,"population":40,"type":44,"unit":28,"dose":45,"refs":47,"durationDays":50},"cinv",{"fa":38,"en":39},"پیشگیری تهوع شیمی‌درمانی بزرگسال — ۰٫۲۵ mg وریدی طی ۳۰ ثانیه، ۳۰ دقیقه پیش از شیمی‌درمانی","CINV prevention, adults — 0.25 mg IV over 30 s, 30 min before chemotherapy",{"minAge":41},{"value":42,"unit":43},18,"year","fixed",{"perDose":46,"dosesPerDay":5},0.25,[48],{"source":32,"section":49},"2.1, Table 1",{"min":5,"max":5},{"id":52,"disease":36,"label":53,"population":56,"type":61,"unit":28,"dose":62,"refs":65,"limits":67,"durationDays":71},"cinv-child",{"fa":54,"en":55},"کودک ۱ ماه تا \u003C۱۷ سال — ۲۰ mcg\u002Fkg (حداکثر ۱٫۵ mg) طی ۱۵ دقیقه","Children 1 month–\u003C17 y — 20 mcg\u002Fkg (max 1.5 mg) over 15 min",{"minAge":57,"maxAge":59},{"value":5,"unit":58},"month",{"value":60,"unit":43},17,"weightBased",{"perKgPerDose":63,"intervalHours":64},0.02,24,[66],{"source":32,"section":49},{"maxPerDose":68,"refs":69},1.5,[70],{"source":32,"section":49},{"min":5,"max":5},{"id":73,"disease":73,"label":74,"population":77,"type":44,"unit":28,"dose":79,"refs":81,"durationDays":84},"ponv",{"fa":75,"en":76},"پیشگیری تهوع پس از جراحی بزرگسال — ۰٫۰۷۵ mg وریدی طی ۱۰ ثانیه درست پیش از القای بیهوشی","PONV prevention, adults — 0.075 mg IV over 10 s immediately before induction",{"minAge":78},{"value":42,"unit":43},{"perDose":80,"dosesPerDay":5},0.075,[82],{"source":32,"section":83},"2.1",{"min":5,"max":5},[86],{"id":87,"severity":88,"text":89,"refs":92},"hyper","block",{"fa":90,"en":91},"حساسیت به پالونوسترون.","Hypersensitivity to palonosetron.",[93],{"source":32,"section":94},"4",[96],{"text":97,"refs":100},{"fa":98,"en":99},"واکنش حساسیتی (حتی با حساسیت به سایر 5-HT3)؛ سندرم سروتونین.","Hypersensitivity (including in those allergic to other 5-HT3 antagonists); serotonin syndrome.",[101],{"source":32,"section":102},"5",[],[],[],{"status":107,"reviewer":108,"date":108},"unverified",null,[110,116,123],{"regimen":36,"formulation":22,"input":111,"expect":114},{"ageYears":112,"weightKg":113},50,70,{"perDose":46,"mlPerDose":115},5,{"regimen":52,"formulation":22,"input":117,"expect":120},{"ageYears":118,"weightKg":119},6,20,{"perDose":121,"mlPerDose":122},0.4,8,{"regimen":73,"formulation":22,"input":124,"expect":126},{"ageYears":125,"weightKg":113},40,{"perDose":80,"mlPerDose":68},[128],"A04AA05",{"status":130,"refs":131},"not-found",[132],{"source":133,"section":134,"url":135},"darooyab-generic","G-2624\u002FPalonosetron","https:\u002F\u002Fwww.darooyab.ir\u002FG-2624\u002FPalonosetron",[137,141,145,149,152],{"kind":138,"url":139,"label":140},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=201533","ANDA201533",{"kind":142,"url":143,"label":144},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=ee6f6f94-1ca7-481e-9909-b19ae64e80c2","FDA Palonosetron",{"kind":146,"url":147,"label":148},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa610002.html","Palonosetron Injection",{"kind":150,"url":151,"label":128},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=A04AA05",{"kind":153,"url":135,"label":8},"darooyab",{"pregnancy":155,"lactation":164,"pediatric":172,"geriatric":180},{"level":156,"text":157,"quote":160,"refs":161},"caution",{"fa":158,"en":159},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","Risk Summary There are no available data on palonosetron HCl use in pregnant women to inform a drug-associated risk.",[162],{"source":32,"section":163},"8.1",{"level":156,"text":165,"quote":168,"refs":169},{"fa":166,"en":167},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","Risk Summary There are no data on the presence of palonosetron in human milk, the effects of palonosetron on the breastfed infant, or the effects of palonosetron on milk production.",[170],{"source":32,"section":171},"8.2",{"level":156,"text":173,"quote":176,"refs":177},{"fa":174,"en":175},"برچسب برای کودکان شرط، محدودیت سنی یا نکته دارد؛ جمله برچسب در زیر آمده است.","The label has conditions, age limits or notes for children; the label sentence is quoted below.","Chemotherapy-Induced Nausea and Vomiting Safety and effectiveness of palonosetron hydrochloride injection have been established in pediatric patients aged 1 month to less than 17 years for the prevention of acute nausea and vomiting associated with initial and repeat courses of emetogenic cancer chemotherapy, …",[178],{"source":32,"section":179},"8.4",{"level":181,"text":182,"quote":185,"refs":186},"ok",{"fa":183,"en":184},"برچسب: در سالمندان تفاوت یا تنظیم دوز خاصی ذکر نشده.","Label: no specific difference or dose adjustment stated for older adults.","No dose adjustment is required for geriatric patients.",[187],{"source":32,"section":188},"8.5",{"kind":190,"refs":191,"id":140},"ANDA",[192],{"source":32,"section":193},"SPL approval \u002F marketing category",1792191559705]