[{"data":1,"prerenderedAt":216},["ShallowReactive",2],{"drug-oxaliplatin":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":22,"regimens":36,"contraindications":69,"warnings":79,"renal":94,"monitoring":104,"interactions":105,"review":106,"examples":109,"atc":118,"iran":120,"usApproval":148,"links":154,"populations":171},"oxaliplatin",1,{"fa":7,"en":8},"اگزالی‌پلاتین","Oxaliplatin","antineoplastic-immunomodulating",{"fa":11,"en":12},"ترکیب پلاتین","Platinum compound",[14],{"name":15,"market":16},"Eloxatin","US",[18,19,20,21],"eloxatin","الوکساتین","اگزالیپلاتین","FOLFOX",[23],{"id":24,"form":25,"route":26,"label":27,"concentration":28,"markets":31,"refs":32},"vial-5","injection","iv","5 mg\u002FmL (50\u002F100\u002F200 mg)",{"amount":29,"unit":30,"perVolumeMl":5},5,"mg",[16],[33],{"source":34,"section":35},"fda-oxaliplatin","3",[37],{"id":38,"disease":39,"label":40,"population":43,"type":47,"unit":30,"dose":48,"refs":50,"durationDays":53,"notes":54},"crc","colorectal-cancer",{"fa":41,"en":42},"سرطان کولورکتال (FOLFOX: کمکی یا پیشرفته) — ۸۵ mg\u002Fm² طی ۱۲۰ دقیقه روز ۱ هر ۲ هفته","Colorectal cancer (FOLFOX: adjuvant or advanced) — 85 mg\u002Fm² over 120 min on day 1 every 2 weeks",{"minAge":44},{"value":45,"unit":46},18,"year","bsa",{"perM2PerDay":49,"dividedDoses":5},85,[51],{"source":34,"section":52},"2.1",{"min":5,"max":5},[55,63],{"text":56,"refs":59},{"fa":57,"en":58},"همزمان با لکوورین ۲۰۰ mg\u002Fm² (کیسه جدا)، سپس فلوئورویوراسیل. کمکی تا ۱۲ دوره. در واکنش حاد انفوزیون تا ۶ ساعت طولانی شود.","Concurrently with leucovorin 200 mg\u002Fm² (separate bag), then fluorouracil. Adjuvant up to 12 cycles. Prolong to 6 h for acute infusion reactions.",[60,61],{"source":34,"section":52},{"source":34,"section":62},"2.2",{"text":64,"refs":67},{"fa":65,"en":66},"فقط زیر نظر پزشک متخصص شیمی‌درمانی و در مرکز مجهز. عدد ماشین‌حساب = mg\u002Fm² برچسب × سطح بدن (Mosteller)؛ پروتکل، فاصله دوره‌ها، تنظیم بر اساس CBC و عملکرد کلیه\u002Fکبد با تیم انکولوژی.","Only under an oncologist in an equipped centre. Calculator = label mg\u002Fm² × BSA (Mosteller); protocol, cycle interval and adjustment for CBC and renal\u002Fhepatic function rest with the oncology team.",[68],{"source":34,"section":52},[70],{"id":71,"severity":72,"text":73,"refs":76},"hyper","block",{"fa":74,"en":75},"سابقه حساسیت به اگزالی‌پلاتین یا سایر داروهای پلاتین.","History of hypersensitivity to oxaliplatin or other platinum drugs.",[77],{"source":34,"section":78},"4",[80,87],{"text":81,"refs":84},{"fa":82,"en":83},"هشدار جعبه‌ای: واکنش حساسیتی و آنافیلاکسی کشنده در هر دوره — قطع دائم.","Boxed warning: serious and fatal hypersensitivity\u002Fanaphylaxis in any cycle — stop permanently.",[85],{"source":34,"section":86},"Boxed Warning",{"text":88,"refs":91},{"fa":89,"en":90},"نوروپاتی حسی (تشدید با سرما)؛ سرکوب شدید مغز استخوان؛ PRES؛ سمیت ریوی و کبدی؛ QT؛ رابدومیولیز؛ خونریزی؛ سمیت جنینی.","Sensory neuropathy (cold-induced); severe myelosuppression; PRES; pulmonary and hepatic toxicity; QT; rhabdomyolysis; haemorrhage; embryo-fetal toxicity.",[92],{"source":34,"section":93},"5",[95],{"egfrBelow":96,"severity":97,"text":98,"refs":101},30,"warn",{"fa":99,"en":100},"ClCr زیر ۳۰: ۶۵ mg\u002Fm².","CrCl \u003C30: 65 mg\u002Fm².",[102],{"source":34,"section":103},"2.3",[],[],{"status":107,"reviewer":108,"date":108},"unverified",null,[110],{"regimen":38,"formulation":24,"input":111,"expect":115},{"ageYears":112,"weightKg":113,"heightCm":114},55,80,180,{"perDose":116,"mlPerDose":117},170,34,[119],"L01XA03",{"status":121,"forms":122,"refs":143},"registered",[123,127,131,135,139],{"code":124,"en":125,"fa":126},"01916","OXALIPLATIN 100MG VIAL","ویال اگزالی‌پلاتین ۱۰۰ میلی‌گرم",{"code":128,"en":129,"fa":130},"07040","OXALIPLATIN 100MG\u002F20ML VIAL","ویال اگزالی‌پلاتین ۱۰۰ میلی‌گرم \u002F ۲۰ میلی‌لیتر",{"code":132,"en":133,"fa":134},"09749","OXALIPLATIN 200MG VIAL","ویال اگزالی‌پلاتین ۲۰۰ میلی‌گرم",{"code":136,"en":137,"fa":138},"01915","OXALIPLATIN 50MG VIAL","ویال اگزالی‌پلاتین ۵۰ میلی‌گرم",{"code":140,"en":141,"fa":142},"07041","OXALIPLATIN 50MG\u002F10ML VIAL","ویال اگزالی‌پلاتین ۵۰ میلی‌گرم \u002F ۱۰ میلی‌لیتر",[144],{"source":145,"section":146,"url":147},"darooyab-generic","G-1043\u002FOxaliplatin","https:\u002F\u002Fwww.darooyab.ir\u002FG-1043\u002FOxaliplatin",{"kind":149,"refs":150,"id":153},"ANDA",[151],{"source":34,"section":152},"SPL approval \u002F marketing category","ANDA207325",[155,158,162,166,169],{"kind":156,"url":157,"label":153},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=207325",{"kind":159,"url":160,"label":161},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=a6f89dc3-a594-4b5b-8728-272e20c1ecb5","FDA Oxaliplatin",{"kind":163,"url":164,"label":165},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa607035.html","Oxaliplatin Injection",{"kind":167,"url":168,"label":119},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=L01XA03",{"kind":170,"url":147,"label":8},"darooyab",{"pregnancy":172,"lactation":181,"pediatric":189,"geriatric":198,"reproductive":207},{"level":173,"text":174,"quote":177,"refs":178},"avoid",{"fa":175,"en":176},"برچسب: می‌تواند به جنین آسیب بزند. در بارداری خطرناک است.","Label: can cause fetal harm. Dangerous in pregnancy.","Risk Summary Based on its direct interaction with DNA, oxaliplatin can cause fetal harm when administered to a pregnant woman.",[179],{"source":34,"section":180},"8.1",{"level":173,"text":182,"quote":185,"refs":186},{"fa":183,"en":184},"برچسب: شیردهی توصیه نمی‌شود یا باید بین دارو و شیردهی یکی انتخاب شود.","Label: breastfeeding not recommended, or choose between the drug and breastfeeding.","Because of the potential for serious adverse reactions in breastfed infants, advise women not to breastfeed during treatment with oxaliplatin and for 3 months after the final dose.",[187],{"source":34,"section":188},"8.2",{"level":190,"text":191,"quote":194,"refs":195},"not-established",{"fa":192,"en":193},"برچسب: ایمنی و اثربخشی در کودکان ثابت نشده است.","Label: safety and effectiveness in children have not been established.","The safety and effectiveness of oxaliplatin in pediatrics have not been established.",[196],{"source":34,"section":197},"8.4",{"level":199,"text":200,"quote":203,"refs":204},"ok",{"fa":201,"en":202},"برچسب: در سالمندان تفاوت یا تنظیم دوز خاصی ذکر نشده.","Label: no specific difference or dose adjustment stated for older adults.","No overall differences in effectiveness were observed between these patients and younger adults.",[205],{"source":34,"section":206},"8.5",{"level":208,"text":209,"quote":212,"refs":213},"caution",{"fa":210,"en":211},"برچسب نکته‌ای درباره بارداری، پیشگیری یا باروری زنان و مردان دارد.","Label has advice on pregnancy testing, contraception or fertility for females and males.","Contraception Oxaliplatin can cause embryo-fetal harm when administered to a pregnant woman [see Use in Specific Populations (8.1) ] .",[214],{"source":34,"section":215},"8.3",1792444415197]