[{"data":1,"prerenderedAt":156},["ShallowReactive",2],{"drug-opicapone":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":20,"regimens":43,"contraindications":68,"warnings":78,"renal":79,"monitoring":80,"interactions":81,"review":82,"examples":85,"atc":91,"iran":93,"usApproval":100,"links":106,"populations":120},"opicapone",1,{"fa":7,"en":8},"اوپیکاپون","Opicapone","nervous-system",{"fa":11,"en":12},"مهارکننده COMT","COMT inhibitor",[14],{"name":15,"market":16},"Ongentys","US",[18,19,7],"ongentys","اونجنتیس",[21,35],{"id":22,"form":23,"route":24,"label":25,"concentration":26,"markets":30,"refs":31},"cap-25","capsule","oral","25 mg capsule",{"amount":27,"unit":28,"perUnit":23,"scored":29},25,"mg",false,[16],[32],{"source":33,"section":34},"fda-ongentys","3",{"id":36,"form":23,"route":24,"label":37,"concentration":38,"markets":40,"refs":41},"cap-50","50 mg capsule",{"amount":39,"unit":28,"perUnit":23,"scored":29},50,[16],[42],{"source":33,"section":34},[44],{"id":45,"disease":46,"label":47,"population":50,"type":54,"unit":28,"dose":55,"refs":56,"notes":59},"pd","parkinsons",{"fa":48,"en":49},"پارکینسون (کمکی لوودوپا، دوره off) — ۵۰ mg یک بار هنگام خواب","Parkinson’s (adjunct to levodopa for \"off\" episodes) — 50 mg once at bedtime",{"minAge":51},{"value":52,"unit":53},18,"year","fixed",{"perDose":39,"dosesPerDay":5},[57],{"source":33,"section":58},"2.1",[60],{"text":61,"refs":64},{"fa":62,"en":63},"یک ساعت قبل و دست‌کم یک ساعت بعد غذا نخورد. نارسایی متوسط کبد: ۲۵ mg؛ شدید: پرهیز.","No food 1 h before and at least 1 h after. Moderate hepatic impairment: 25 mg; severe: avoid.",[65,66],{"source":33,"section":58},{"source":33,"section":67},"2.2",[69],{"id":70,"severity":71,"text":72,"refs":75},"ci","block",{"fa":73,"en":74},"MAOI غیرانتخابی همزمان؛ فئوکروموسیتوم، پاراگانگلیوم یا تومورهای ترشح‌کننده کاتکول‌آمین.","Concomitant non-selective MAOIs; phaeochromocytoma, paraganglioma or other catecholamine-secreting tumours.",[76],{"source":33,"section":77},"4",[],[],[],[],{"status":83,"reviewer":84,"date":84},"unverified",null,[86],{"regimen":45,"formulation":36,"input":87,"expect":90},{"ageYears":88,"weightKg":89},65,70,{"perDose":39,"tabletsPerDoseRounded":5},[92],"N04BX04",{"status":94,"refs":95},"not-found",[96],{"source":97,"section":98,"url":99},"darooyab-generic","search","https:\u002F\u002Fwww.darooyab.ir\u002FSearch?q=Opicapone",{"kind":101,"refs":102,"id":105},"NDA",[103],{"source":33,"section":104},"SPL approval \u002F marketing category","NDA212489",[107,110,114,117],{"kind":108,"url":109,"label":105},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=212489",{"kind":111,"url":112,"label":113},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=a511a531-112e-43f8-a43f-5334b0efe979","FDA Ongentys",{"kind":115,"url":116,"label":8},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa620059.html",{"kind":118,"url":119,"label":92},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=N04BX04",{"pregnancy":121,"lactation":130,"pediatric":138,"geriatric":147},{"level":122,"text":123,"quote":126,"refs":127},"caution",{"fa":124,"en":125},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","Risk Summary There are no adequate data on the developmental risk associated with use of ONGENTYS in pregnant women.",[128],{"source":33,"section":129},"8.1",{"level":122,"text":131,"quote":134,"refs":135},{"fa":132,"en":133},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","Risk Summary There are no data on the presence of opicapone in human milk, the effects on the breastfed infant, or the effects on milk production.",[136],{"source":33,"section":137},"8.2",{"level":139,"text":140,"quote":143,"refs":144},"not-established",{"fa":141,"en":142},"برچسب: ایمنی و اثربخشی در کودکان ثابت نشده است.","Label: safety and effectiveness in children have not been established.","Safety and effectiveness in pediatric patients have not been established.",[145],{"source":33,"section":146},"8.4",{"level":148,"text":149,"quote":152,"refs":153},"ok",{"fa":150,"en":151},"برچسب: در سالمندان تفاوت یا تنظیم دوز خاصی ذکر نشده.","Label: no specific difference or dose adjustment stated for older adults.","No dose adjustment is required for elderly patients.",[154],{"source":33,"section":155},"8.5",1792156189696]