[{"data":1,"prerenderedAt":233},["ShallowReactive",2],{"drug-ondansetron":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":20,"regimens":55,"contraindications":144,"warnings":161,"renal":196,"monitoring":197,"interactions":198,"review":199,"examples":202},"ondansetron",1,{"fa":7,"en":8},"اندانسترون","Ondansetron","gastrointestinal",{"fa":11,"en":12},"آنتاگونیست گیرنده 5-HT3","5-HT3 receptor antagonist",[14],{"name":15,"market":16},"Zofran","US",[18,19],"ondansetrone","زوفران",[21,35,43],{"id":22,"form":23,"route":24,"label":25,"concentration":26,"markets":30,"refs":31},"tab-4","tablet","oral","4 mg tablet",{"amount":27,"unit":28,"perUnit":23,"scored":29},4,"mg",false,[16],[32],{"source":33,"section":34},"fda-ondansetron-tab","3",{"id":36,"form":23,"route":24,"label":37,"concentration":38,"markets":40,"refs":41},"tab-8","8 mg tablet",{"amount":39,"unit":28,"perUnit":23,"scored":29},8,[16],[42],{"source":33,"section":34},{"id":44,"form":45,"route":24,"label":46,"concentration":47,"markets":48,"refs":49},"odt-4","odt","4 mg orally disintegrating tablet",{"amount":27,"unit":28,"perUnit":23,"scored":29},[16],[50],{"source":33,"section":51,"note":52},"2.1",{"fa":53,"en":54},"قرص، ODT و محلول در دوز معادل قابل جایگزینی‌اند","Tablets, ODT and oral solution interchangeable at corresponding doses",[56,98,124],{"id":57,"disease":58,"label":59,"population":62,"type":66,"unit":28,"dose":67,"refs":70,"limits":74,"durationDays":77,"notes":78},"age-vomiting","gastroenteritis-vomiting",{"fa":60,"en":61},"استفراغ گاستروآنتریت — تک‌دوز ۰٫۱۵ mg\u002Fkg (حداکثر ۸ mg)","Gastroenteritis vomiting — single dose 0.15 mg\u002Fkg (max 8 mg)",{"minAge":63,"minWeightKg":39},{"value":64,"unit":65},6,"month","weightBased",{"perKgPerDose":68,"intervalHours":69},0.15,24,[71],{"source":72,"section":73},"cps-ondansetron-2018","Recommendations",{"maxPerDose":39,"refs":75},[76],{"source":72,"section":73},{"min":5,"max":5},[79,85,91],{"text":80,"refs":83},{"fa":81,"en":82},"فقط یک دوز؛ دوزهای متعدد سودی ندارد. ORS از ۱۵ تا ۳۰ دقیقه بعد شروع شود. برای کودک با دهیدراتاسیون خفیف تا متوسط یا شکست ORS؛ در اسهال شدید غالب روتین نیست.","Single dose only; no benefit from multiple doses. Start oral rehydration 15–30 min later. For mild–moderate dehydration or failed ORS; not routine when moderate–severe diarrhea predominates.",[84],{"source":72,"section":73},{"text":86,"refs":89},{"fa":87,"en":88},"جایگزین وزنی: ۸–۱۵ kg: ۲ mg؛ ۱۵–۳۰ kg: ۴ mg؛ بیش از ۳۰ kg: ۶–۸ mg. فرم مایع توصیه شده؛ قرص ۴ mg برای دوز کمتر از ۴ mg مناسب نیست.","Weight-band alternative: 8–15 kg 2 mg; 15–30 kg 4 mg; >30 kg 6–8 mg. Liquid form recommended; a 4 mg tablet cannot give doses below 4 mg.",[90],{"source":72,"section":73},{"text":92,"refs":95},{"fa":93,"en":94},"این کاربرد در برچسب FDA نیست (برچسب: پیشگیری از تهوع شیمی‌درمانی و پس از عمل).","This use is not in the FDA label (label: chemotherapy and postoperative nausea prevention).",[96],{"source":33,"section":97},"1",{"id":99,"disease":100,"label":101,"population":104,"type":109,"unit":28,"dose":110,"refs":112,"notes":117},"cinv-4-11","cinv",{"fa":102,"en":103},"تهوع شیمی‌درمانی متوسط — ۴ تا ۱۱ سال: ۴ mg","Moderately emetogenic chemotherapy — 4–11 years: 4 mg",{"minAge":105,"maxAge":107},{"value":27,"unit":106},"year",{"value":108,"unit":106},12,"fixed",{"perDose":27,"dosesPerDay":111},3,[113,115],{"source":33,"section":114},"2.1, Table 2",{"source":33,"section":116},"8.4",[118],{"text":119,"refs":122},{"fa":120,"en":121},"۴ mg سی دقیقه قبل از شیمی‌درمانی، سپس ۴ و ۸ ساعت بعد؛ سپس ۴ mg سه بار در روز تا ۱–۲ روز پس از پایان.","4 mg 30 min before chemotherapy, then at 4 and 8 h; then 4 mg three times a day for 1–2 days after completion.",[123],{"source":33,"section":114},{"id":125,"disease":100,"label":126,"population":129,"type":109,"unit":28,"dose":131,"refs":133,"notes":137},"cinv-12-17",{"fa":127,"en":128},"تهوع شیمی‌درمانی متوسط — ۱۲ تا ۱۷ سال: ۸ mg","Moderately emetogenic chemotherapy — 12–17 years: 8 mg",{"minAge":130},{"value":108,"unit":106},{"perDose":39,"dosesPerDay":132},2,[134,135],{"source":33,"section":114},{"source":33,"section":136},"2.1, Table 1",[138],{"text":139,"refs":142},{"fa":140,"en":141},"۸ mg سی دقیقه قبل، دوز دوم ۸ ساعت بعد؛ سپس ۸ mg هر ۱۲ ساعت تا ۱–۲ روز پس از پایان.","8 mg 30 min before, second dose 8 h later; then 8 mg every 12 h for 1–2 days after completion.",[143],{"source":33,"section":114},[145,154],{"id":146,"severity":147,"text":148,"refs":151},"hypersensitivity","block",{"fa":149,"en":150},"حساسیت (مثل آنافیلاکسی) به اندانسترون.","Hypersensitivity (e.g. anaphylaxis) to ondansetron.",[152],{"source":33,"section":153},"4",{"id":155,"severity":147,"text":156,"refs":159},"apomorphine",{"fa":157,"en":158},"مصرف همزمان آپومورفین (افت فشار شدید و کاهش هوشیاری).","Concomitant apomorphine (profound hypotension, loss of consciousness).",[160],{"source":33,"section":153},[162,169,176,183,190],{"text":163,"refs":166},{"fa":164,"en":165},"طولانی شدن QT","QT prolongation",[167],{"source":33,"section":168},"5.2",{"text":170,"refs":173},{"fa":171,"en":172},"سندرم سروتونین","Serotonin syndrome",[174],{"source":33,"section":175},"5.3",{"text":177,"refs":180},{"fa":178,"en":179},"ایسکمی میوکارد","Myocardial ischemia",[181],{"source":33,"section":182},"5.4",{"text":184,"refs":187},{"fa":185,"en":186},"ممکن است ایلئوس پیشرونده را بپوشاند","May mask progressive ileus and gastric distension",[188],{"source":33,"section":189},"5.5",{"text":191,"refs":194},{"fa":192,"en":193},"برای ECG و الکترولیت روتین پیش از تک‌دوز خوراکی در کودک بدون عامل خطر شواهدی نیست.","Routine ECG\u002Felectrolyte screening before a single oral dose is not supported in children without known risk factors.",[195],{"source":72,"section":73},[],[],[],{"status":200,"reviewer":201,"date":201},"unverified",null,[203,207,212,216,221,225,229],{"regimen":57,"formulation":22,"input":204,"expect":205},{"ageYears":132,"weightKg":108},{"status":206},"blocked",{"regimen":57,"formulation":22,"input":208,"expect":210},{"ageYears":39,"weightKg":209},26,{"perDose":211,"tabletsPerDoseRounded":5},3.9,{"regimen":57,"formulation":22,"input":213,"expect":215},{"ageYears":39,"weightKg":214},30,{"status":206},{"regimen":57,"formulation":36,"input":217,"expect":220},{"ageYears":218,"weightKg":219},14,60,{"perDose":39},{"regimen":57,"formulation":22,"input":222,"expect":224},{"ageMonths":223,"weightKg":223},7,{"status":206},{"regimen":99,"formulation":22,"input":226,"expect":228},{"ageYears":64,"weightKg":227},20,{"tabletsPerDoseRounded":5},{"regimen":125,"formulation":36,"input":230,"expect":232},{"ageYears":218,"weightKg":231},50,{"tabletsPerDoseRounded":5},1792078538975]