[{"data":1,"prerenderedAt":173},["ShallowReactive",2],{"drug-nicardipine-iv":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":21,"regimens":43,"contraindications":70,"warnings":80,"renal":88,"monitoring":89,"interactions":90,"review":91,"examples":94,"atc":102,"iran":104,"usApproval":116,"links":122,"populations":139},"nicardipine-iv",1,{"fa":7,"en":8},"نیکاردیپین وریدی","Nicardipine (IV)","cardiovascular",{"fa":11,"en":12},"مسدودکننده کانال کلسیم دی‌هیدروپیریدینی","Dihydropyridine calcium channel blocker",[14],{"name":15,"market":16},"Cardene IV","US",[18,19,20],"cardene","کاردن","نیکاردیپین",[22,35],{"id":23,"form":24,"route":25,"label":26,"concentration":27,"markets":30,"refs":31},"bag-01","injection","iv","20 mg\u002F200 mL premixed (0.1 mg\u002FmL)",{"amount":28,"unit":29,"perVolumeMl":5},0.1,"mg",[16],[32],{"source":33,"section":34},"fda-cardene-iv","3",{"id":36,"form":24,"route":25,"label":37,"concentration":38,"markets":40,"refs":41},"bag-02","40 mg\u002F200 mL premixed (0.2 mg\u002FmL)",{"amount":39,"unit":29,"perVolumeMl":5},0.2,[16],[42],{"source":33,"section":34},[44],{"id":45,"disease":46,"label":47,"population":50,"type":54,"unit":29,"dose":55,"refs":58,"notes":61},"htn","hypertensive-emergency",{"fa":48,"en":49},"افزایش شدید فشار خون (وقتی خوراکی ممکن نیست) — شروع ۵ mg\u002Fساعت، حداکثر ۱۵ mg\u002Fساعت","Severe hypertension when oral therapy is not feasible — start 5 mg\u002Fh, max 15 mg\u002Fh",{"minAge":51},{"value":52,"unit":53},18,"year","infusion",{"perMin":56,"perMinMax":57},0.08333,0.25,[59],{"source":33,"section":60},"2.1",[62],{"text":63,"refs":66},{"fa":64,"en":65},"شروع ۵ mg\u002Fساعت؛ هر ۵ تا ۱۵ دقیقه ۲٫۵ mg\u002Fساعت بیشتر تا حداکثر ۱۵ mg\u002Fساعت. ماشین‌حساب سرعت mL\u002Fساعت کیسه را نشان می‌دهد. از ورید مرکزی یا محیطی بزرگ؛ محل محیطی هر ۱۲ ساعت عوض شود.","Start 5 mg\u002Fh; increase by 2.5 mg\u002Fh every 5–15 min to max 15 mg\u002Fh. The calculator shows bag mL\u002Fh. Central or large peripheral vein; change peripheral site every 12 h.",[67,68],{"source":33,"section":60},{"source":33,"section":69},"2.3",[71],{"id":72,"severity":73,"text":74,"refs":77},"as","block",{"fa":75,"en":76},"تنگی پیشرفته دریچه آئورت.","Advanced aortic stenosis.",[78],{"source":33,"section":79},"4",[81],{"text":82,"refs":85},{"fa":83,"en":84},"پایش دقیق در آنژین، نارسایی قلب، کبد یا کلیه؛ از وریدهای کوچک دست استفاده نشود (ترومبوز و فلبیت)؛ از تزریق داخل شریان یا نشت پرهیز.","Monitor closely in angina, heart failure, hepatic or renal impairment; avoid small hand\u002Fwrist veins (thrombosis, phlebitis); avoid intra-arterial injection or extravasation.",[86],{"source":33,"section":87},"5",[],[],[],{"status":92,"reviewer":93,"date":93},"unverified",null,[95],{"regimen":45,"formulation":23,"input":96,"expect":99},{"ageYears":97,"weightKg":98},60,80,{"mlPerHour":100,"upperMlPerHour":101},50,150,[103],"C08CA04",{"status":105,"forms":106,"refs":111},"registered",[107],{"code":108,"en":109,"fa":110},"52516","NICARDIPINE HYDROCHLORIDE CAPSULE ORAL 20 mg","کپسول نیکاردیپین هیدروکلراید ۲۰ میلی‌گرم",[112],{"source":113,"section":114,"url":115},"darooyab-generic","G-1790\u002FNicardipine","https:\u002F\u002Fwww.darooyab.ir\u002FG-1790\u002FNicardipine",{"kind":117,"refs":118,"id":121},"NDA",[119],{"source":33,"section":120},"SPL approval \u002F marketing category","NDA019734",[123,126,130,134,137],{"kind":124,"url":125,"label":121},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=019734",{"kind":127,"url":128,"label":129},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=5499cfac-9147-4d5d-a8cb-f8d64f1481af","FDA Cardene IV",{"kind":131,"url":132,"label":133},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa695032.html","Nicardipine",{"kind":135,"url":136,"label":103},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=C08CA04",{"kind":138,"url":115,"label":133},"darooyab",{"pregnancy":140,"lactation":149,"pediatric":157,"geriatric":165},{"level":141,"text":142,"quote":145,"refs":146},"caution",{"fa":143,"en":144},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","Risk Summary Available data from published literature (clinical trials and case series) over decades of use of intravenous nicardipine during pregnancy have not identified a drug-associated risk of major birth defects or miscarriage.",[147],{"source":33,"section":148},"8.1",{"level":141,"text":150,"quote":153,"refs":154},{"fa":151,"en":152},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","Risk Summary Nicardipine is present in human milk in low amounts.",[155],{"source":33,"section":156},"8.2",{"level":141,"text":158,"quote":161,"refs":162},{"fa":159,"en":160},"برچسب برای کودکان شرط، محدودیت سنی یا نکته دارد؛ جمله برچسب در زیر آمده است.","The label has conditions, age limits or notes for children; the label sentence is quoted below.","The safety and effectiveness of CARDENE I.V. have not been established in pediatric patients.",[163],{"source":33,"section":164},"8.4",{"level":141,"text":166,"quote":169,"refs":170},{"fa":167,"en":168},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","The steady-state pharmacokinetics of nicardipine are similar in elderly hypertensive patients (>65 years) and young healthy adults.",[171],{"source":33,"section":172},"8.5",1792191557074]