[{"data":1,"prerenderedAt":209},["ShallowReactive",2],{"drug-neostigmine":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":21,"regimens":42,"contraindications":94,"warnings":104,"renal":113,"monitoring":114,"interactions":115,"review":116,"examples":119,"atc":130,"iran":132,"usApproval":156,"links":162,"populations":175},"neostigmine",1,{"fa":7,"en":8},"نئوستیگمین","Neostigmine","nervous-system",{"fa":11,"en":12},"مهارکننده کولین‌استراز","Cholinesterase inhibitor",[14],{"name":15,"market":16},"Bloxiverz","US",[18,19,7,20],"bloxiverz","prostigmin","پروستیگمین",[22,35],{"id":23,"form":24,"route":25,"label":26,"concentration":27,"markets":30,"refs":31},"inj-05","injection","iv","0.5 mg\u002FmL (10 mL vial)",{"amount":28,"unit":29,"perVolumeMl":5},0.5,"mg",[16],[32],{"source":33,"section":34},"fda-neostigmine","3",{"id":36,"form":24,"route":25,"label":37,"concentration":38,"markets":39,"refs":40},"inj-1","1 mg\u002FmL (10 mL vial)",{"amount":5,"unit":29,"perVolumeMl":5},[16],[41],{"source":33,"section":34},[43,73],{"id":44,"disease":45,"label":46,"population":49,"type":50,"unit":29,"dose":51,"refs":54,"limits":57,"durationDays":61,"notes":62},"short","nmb-reversal",{"fa":47,"en":48},"برگرداندن شل‌کننده کوتاه‌اثر یا پاسخ اول TOF خیلی بیشتر از ۱۰٪ — ۰٫۰۳ mg\u002Fkg","Reversal of shorter-acting NMBA, or first twitch well above 10% — 0.03 mg\u002Fkg",{},"weightBased",{"perKgPerDose":52,"intervalHours":53},0.03,24,[55],{"source":33,"section":56},"2.2",{"maxPerDose":58,"refs":59},5,[60],{"source":33,"section":56},{"min":5,"max":5},[63],{"text":64,"refs":67},{"fa":65,"en":66},"فقط وقتی پاسخ اول TOF دست‌کم ۱۰٪ پایه باشد. آتروپین یا گلیکوپیرولات قبل یا همزمان (با سرنگ جدا). کودکان مانند بزرگسال.","Only when the first TOF twitch is at least 10% of baseline. Atropine or glycopyrrolate before or with it (separate syringe). Children dosed as adults.",[68,69,71],{"source":33,"section":56},{"source":33,"section":70},"2.4",{"source":33,"section":72},"2.3",{"id":74,"disease":45,"label":75,"population":78,"type":50,"unit":29,"dose":79,"refs":81,"limits":83,"durationDays":86,"notes":87},"long",{"fa":76,"en":77},"برگرداندن شل‌کننده طولانی‌اثر یا پاسخ اول نزدیک ۱۰٪ — ۰٫۰۷ mg\u002Fkg (حداکثر ۵ mg)","Reversal of longer-acting NMBA, or first twitch near 10% — 0.07 mg\u002Fkg (max 5 mg)",{},{"perKgPerDose":80,"intervalHours":53},0.07,[82],{"source":33,"section":56},{"maxPerDose":58,"refs":84},[85],{"source":33,"section":56},{"min":5,"max":5},[88],{"text":89,"refs":90},{"fa":65,"en":66},[91,92,93],{"source":33,"section":56},{"source":33,"section":70},{"source":33,"section":72},[95],{"id":96,"severity":97,"text":98,"refs":101},"ci","block",{"fa":99,"en":100},"حساسیت به نئوستیگمین؛ پریتونیت یا انسداد مکانیکی روده یا مجاری ادرار.","Hypersensitivity to neostigmine; peritonitis or mechanical obstruction of the intestinal or urinary tract.",[102],{"source":33,"section":103},"4",[105],{"text":106,"refs":109},{"fa":107,"en":108},"برادی‌کاردی، برونکواسپاسم؛ حداکثر کل ۰٫۰۷ mg\u002Fkg یا ۵ mg (هر کدام کمتر).","Bradycardia, bronchospasm; maximum total 0.07 mg\u002Fkg or 5 mg (whichever is less).",[110,112],{"source":33,"section":111},"5",{"source":33,"section":56},[],[],[],{"status":117,"reviewer":118,"date":118},"unverified",null,[120,126],{"regimen":44,"formulation":36,"input":121,"expect":124},{"ageYears":122,"weightKg":123},40,70,{"perDose":125,"mlPerDose":125},2.1,{"regimen":74,"formulation":36,"input":127,"expect":128},{"ageYears":122,"weightKg":123},{"perDose":129,"mlPerDose":129},4.9,[131],"N07AA01",{"status":133,"forms":134,"refs":151},"registered",[135,139,143,147],{"code":136,"en":137,"fa":138},"01817","NEOSTIGMINE BROMIDE 15MG TAB","قرص نئوستیگمین بروماید ۱۵ میلی‌گرم",{"code":140,"en":141,"fa":142},"00893","NEOSTIGMINE METHYLSULFATE 0.5MG\u002F1ML AMP","آمپول نئوستیگمین متیل‌سولفات ۰٫۵ میلی‌گرم \u002F ۱ میلی‌لیتر",{"code":144,"en":145,"fa":146},"00894","NEOSTIGMINE METHYLSULFATE 12.5MG\u002F5ML AMP","آمپول نئوستیگمین متیل‌سولفات ۱۲٫۵ میلی‌گرم \u002F ۵ میلی‌لیتر",{"code":148,"en":149,"fa":150},"00895","NEOSTIGMINE METHYLSULFATE 2.5MG\u002F1ML AMP","آمپول نئوستیگمین متیل‌سولفات ۲٫۵ میلی‌گرم \u002F ۱ میلی‌لیتر",[152],{"source":153,"section":154,"url":155},"darooyab-generic","G-3049\u002FNeostigmine","https:\u002F\u002Fwww.darooyab.ir\u002FG-3049\u002FNeostigmine",{"kind":157,"refs":158,"id":161},"ANDA",[159],{"source":33,"section":160},"SPL approval \u002F marketing category","ANDA208405",[163,166,170,173],{"kind":164,"url":165,"label":161},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=208405",{"kind":167,"url":168,"label":169},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=673140f7-273e-4543-98b5-6b12c59f540b","FDA Neostigmine",{"kind":171,"url":172,"label":131},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=N07AA01",{"kind":174,"url":155,"label":8},"darooyab",{"pregnancy":176,"lactation":185,"pediatric":193,"geriatric":201},{"level":177,"text":178,"quote":181,"refs":182},"caution",{"fa":179,"en":180},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","Risk Summary There are no adequate or well-controlled studies of neostigmine methylsulfate injection in pregnant women.",[183],{"source":33,"section":184},"8.1",{"level":177,"text":186,"quote":189,"refs":190},{"fa":187,"en":188},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","Risk summary Neostigmine methylsulfate has not been studied in lactating women.",[191],{"source":33,"section":192},"8.2",{"level":177,"text":194,"quote":197,"refs":198},{"fa":195,"en":196},"برچسب برای کودکان شرط، محدودیت سنی یا نکته دارد؛ جمله برچسب در زیر آمده است.","The label has conditions, age limits or notes for children; the label sentence is quoted below.","Neostigmine methylsulfate injection is approved for the reversal of the effects of non-depolarizing neuromuscular blocking agents after surgery in pediatric patients of all ages.",[199],{"source":33,"section":200},"8.4",{"level":177,"text":202,"quote":205,"refs":206},{"fa":203,"en":204},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","Because elderly patients are more likely to have decreased renal function, neostigmine methylsulfate injection should be used with caution and monitored for a longer period in elderly patients.",[207],{"source":33,"section":208},"8.5",1792156188561]