[{"data":1,"prerenderedAt":188},["ShallowReactive",2],{"drug-modafinil":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":20,"regimens":44,"contraindications":80,"warnings":90,"renal":98,"monitoring":99,"interactions":100,"review":101,"examples":104,"atc":113,"iran":115,"usApproval":131,"links":137,"populations":153},"modafinil",1,{"fa":7,"en":8},"مودافینیل","Modafinil","nervous-system",{"fa":11,"en":12},"محرک بیداری","Wakefulness-promoting agent",[14],{"name":15,"market":16},"Provigil","US",[18,19,7],"provigil","پروویژیل",[21,35],{"id":22,"form":23,"route":24,"label":25,"concentration":26,"markets":30,"refs":31},"tab-100","tablet","oral","100 mg tablet",{"amount":27,"unit":28,"perUnit":23,"scored":29},100,"mg",false,[16],[32],{"source":33,"section":34},"fda-modafinil","3",{"id":36,"form":23,"route":24,"label":37,"concentration":38,"markets":41,"refs":42},"tab-200","200 mg tablet (scored)",{"amount":39,"unit":28,"perUnit":23,"scored":40},200,true,[16],[43],{"source":33,"section":34},[45,69],{"id":46,"disease":47,"label":48,"population":51,"type":55,"unit":28,"dose":56,"refs":57,"notes":60},"narco","narcolepsy",{"fa":49,"en":50},"نارکولپسی یا آپنه انسدادی خواب — ۲۰۰ mg یک بار صبح","Narcolepsy or obstructive sleep apnoea — 200 mg once in the morning",{"minAge":52},{"value":53,"unit":54},18,"year","fixed",{"perDose":39,"dosesPerDay":5},[58],{"source":33,"section":59},"2.1",[61],{"text":62,"refs":65},{"fa":63,"en":64},"تا ۴۰۰ mg تحمل شده ولی سود بیشتری ثابت نشده. نارسایی شدید کبد: نصف دوز. سالمند: دوز کمتر.","Up to 400 mg tolerated but no consistent extra benefit. Severe hepatic impairment: half dose. Elderly: consider lower dose.",[66,67],{"source":33,"section":59},{"source":33,"section":68},"2",{"id":70,"disease":47,"label":71,"population":74,"type":55,"unit":28,"dose":76,"refs":77},"swd",{"fa":72,"en":73},"اختلال کار شیفتی — ۲۰۰ mg حدود ۱ ساعت قبل از شروع شیفت","Shift work disorder — 200 mg about 1 h before the shift",{"minAge":75},{"value":53,"unit":54},{"perDose":39,"dosesPerDay":5},[78],{"source":33,"section":79},"2.2",[81],{"id":82,"severity":83,"text":84,"refs":87},"hyper","block",{"fa":85,"en":86},"حساسیت به مودافینیل یا آرمودافینیل.","Hypersensitivity to modafinil or armodafinil.",[88],{"source":33,"section":89},"4",[91],{"text":92,"refs":95},{"fa":93,"en":94},"بثورات جدی پوستی (SJS) — قطع با اولین بثورات؛ آنژیوادم و آنافیلاکسی؛ حساسیت چندارگانی؛ خواب‌آلودگی پایدار؛ علائم روانی.","Serious rash (SJS) — stop at the first rash; angioedema and anaphylaxis; multi-organ hypersensitivity; persistent sleepiness; psychiatric symptoms.",[96],{"source":33,"section":97},"5",[],[],[],{"status":102,"reviewer":103,"date":103},"unverified",null,[105,110],{"regimen":46,"formulation":36,"input":106,"expect":109},{"ageYears":107,"weightKg":108},30,70,{"perDose":39,"tabletsPerDoseRounded":5},{"regimen":70,"formulation":36,"input":111,"expect":112},{"ageYears":107,"weightKg":108},{"perDose":39,"tabletsPerDoseRounded":5},[114],"N06BA07",{"status":116,"forms":117,"refs":126},"registered",[118,122],{"code":119,"en":120,"fa":121},"06579","MODAFINIL 100MG TAB","قرص مودافینیل ۱۰۰ میلی‌گرم",{"code":123,"en":124,"fa":125},"08504","MODAFINIL 200MG TAB","قرص مودافینیل ۲۰۰ میلی‌گرم",[127],{"source":128,"section":129,"url":130},"darooyab-generic","G-3393\u002FModafinil","https:\u002F\u002Fwww.darooyab.ir\u002FG-3393\u002FModafinil",{"kind":132,"refs":133,"id":136},"ANDA",[134],{"source":33,"section":135},"SPL approval \u002F marketing category","ANDA207196",[138,141,145,148,151],{"kind":139,"url":140,"label":136},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=207196",{"kind":142,"url":143,"label":144},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=1a309416-bd6a-45b1-982f-b689b097453d","FDA Modafinil",{"kind":146,"url":147,"label":8},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa602016.html",{"kind":149,"url":150,"label":114},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=N06BA07",{"kind":152,"url":130,"label":8},"darooyab",{"pregnancy":154,"lactation":163,"pediatric":171,"geriatric":180},{"level":155,"text":156,"quote":159,"refs":160},"caution",{"fa":157,"en":158},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","Pregnancy Category C There are no adequate and well-controlled studies of modafinil in pregnant women.",[161],{"source":33,"section":162},"8.1",{"level":155,"text":164,"quote":167,"refs":168},{"fa":165,"en":166},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","Because many drugs are excreted in human milk, caution should be exercised when modafinil tablets are administered to a nursing woman.",[169],{"source":33,"section":170},"8.3",{"level":172,"text":173,"quote":176,"refs":177},"not-established",{"fa":174,"en":175},"برچسب: ایمنی و اثربخشی در کودکان ثابت نشده است.","Label: safety and effectiveness in children have not been established.","Safety and effectiveness in pediatric patients have not been established.",[178],{"source":33,"section":179},"8.4",{"level":155,"text":181,"quote":184,"refs":185},{"fa":182,"en":183},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","Therefore, consideration should be given to the use of lower doses and close monitoring in this population [see Dosage and Administration (2.4) and Clinical Pharmacology (12.3)].",[186],{"source":33,"section":187},"8.5",1792156187860]