[{"data":1,"prerenderedAt":184},["ShallowReactive",2],{"drug-mexiletine":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":16,"formulations":19,"regimens":50,"contraindications":75,"warnings":85,"renal":93,"monitoring":94,"interactions":95,"review":96,"examples":99,"atc":105,"iran":107,"usApproval":135,"links":141,"populations":157},"mexiletine",1,{"fa":7,"en":8},"مگزیلتین","Mexiletine","cardiovascular",{"fa":11,"en":12},"ضدآریتمی کلاس IB","Class IB antiarrhythmic",[14],{"name":8,"market":15},"US",[17,18,7],"mexitil","مکزیلتین",[20,34,42],{"id":21,"form":22,"route":23,"label":24,"concentration":25,"markets":29,"refs":30},"cap-200","capsule","oral","200 mg capsule",{"amount":26,"unit":27,"perUnit":22,"scored":28},200,"mg",false,[15],[31],{"source":32,"section":33},"fda-mexiletine","How Supplied",{"id":35,"form":22,"route":23,"label":36,"concentration":37,"markets":39,"refs":40},"cap-150","150 mg capsule",{"amount":38,"unit":27,"perUnit":22,"scored":28},150,[15],[41],{"source":32,"section":33},{"id":43,"form":22,"route":23,"label":44,"concentration":45,"markets":47,"refs":48},"cap-250","250 mg capsule",{"amount":46,"unit":27,"perUnit":22,"scored":28},250,[15],[49],{"source":32,"section":33},[51],{"id":52,"disease":53,"label":54,"population":57,"type":61,"unit":27,"dose":62,"refs":65,"notes":68},"va","ventricular-arrhythmia",{"fa":55,"en":56},"آریتمی بطنی تهدیدکننده حیات — شروع ۲۰۰ mg هر ۸ ساعت با غذا","Life-threatening ventricular arrhythmia — start 200 mg every 8 h with food",{"minAge":58},{"value":59,"unit":60},18,"year","fixed",{"perDose":26,"perDoseMax":63,"dosesPerDay":64},300,3,[66],{"source":32,"section":67},"Dosage and Administration",[69],{"text":70,"refs":73},{"fa":71,"en":72},"بیشتر بیماران با ۲۰۰ تا ۳۰۰ mg هر ۸ ساعت کنترل می‌شوند؛ تغییر ۵۰ یا ۱۰۰ mg با فاصله ۲ تا ۳ روز. کنترل سریع: بارگذاری ۴۰۰ mg و ۸ ساعت بعد ۲۰۰ mg. ECG و هولتر.","Most are controlled by 200–300 mg every 8 h; adjust by 50 or 100 mg every 2–3 days. Rapid control: 400 mg loading then 200 mg 8 h later. ECG and Holter monitoring.",[74],{"source":32,"section":67},[76],{"id":77,"severity":78,"text":79,"refs":82},"ci","block",{"fa":80,"en":81},"شوک کاردیوژنیک؛ بلوک AV درجه ۲ یا ۳ بدون پیس‌میکر.","Cardiogenic shock; second- or third-degree AV block without a pacemaker.",[83],{"source":32,"section":84},"Contraindications",[86],{"text":87,"refs":90},{"fa":88,"en":89},"هشدار جعبه‌ای: افزایش مرگ با ضدآریتمی‌های کلاس I پس از MI (مطالعه CAST) — فقط برای آریتمی بطنی تهدیدکننده حیات.","Boxed warning: increased mortality with class I antiarrhythmics after MI (CAST) — reserve for life-threatening ventricular arrhythmia.",[91],{"source":32,"section":92},"Boxed Warning",[],[],[],{"status":97,"reviewer":98,"date":98},"unverified",null,[100],{"regimen":52,"formulation":21,"input":101,"expect":104},{"ageYears":102,"weightKg":103},60,75,{"perDose":26,"tabletsPerDoseRounded":5},[106],"C01BB02",{"status":108,"forms":109,"refs":130},"registered",[110,114,118,122,126],{"code":111,"en":112,"fa":113},"00848","MEXILETINE HCL 100MG CAP","کپسول مکزیلتین هیدروکلراید ۱۰۰ میلی‌گرم",{"code":115,"en":116,"fa":117},"14557","MEXILETINE HCL 100MG TAB","قرص مکزیلتین هیدروکلراید ۱۰۰ میلی‌گرم",{"code":119,"en":120,"fa":121},"00849","MEXILETINE HCL 200MG CAP","کپسول مکزیلتین هیدروکلراید ۲۰۰ میلی‌گرم",{"code":123,"en":124,"fa":125},"17782","MEXILETINE HCL 200MG TAB","قرص مکزیلتین هیدروکلراید ۲۰۰ میلی‌گرم",{"code":127,"en":128,"fa":129},"09574","MEXILETINE HCL 50MG TAB","قرص مکزیلتین هیدروکلراید ۵۰ میلی‌گرم",[131],{"source":132,"section":133,"url":134},"darooyab-generic","G-1769\u002FMexiletine","https:\u002F\u002Fwww.darooyab.ir\u002FG-1769\u002FMexiletine",{"kind":136,"refs":137,"id":140},"ANDA",[138],{"source":32,"section":139},"SPL approval \u002F marketing category","ANDA214089",[142,145,149,152,155],{"kind":143,"url":144,"label":140},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=214089",{"kind":146,"url":147,"label":148},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=58b7a7f5-5ae0-2f60-e063-6394a90a37dd","FDA Mexiletine",{"kind":150,"url":151,"label":8},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa607064.html",{"kind":153,"url":154,"label":106},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=C01BB02",{"kind":156,"url":134,"label":8},"darooyab",{"pregnancy":158,"lactation":167,"pediatric":175},{"level":159,"text":160,"quote":163,"refs":164},"caution",{"fa":161,"en":162},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","Teratogenic Effects Reproduction studies performed with mexiletine in rats, mice and rabbits at doses up to four times the maximum human oral dose (24 mg\u002Fkg in a 50 kg patient) revealed no evidence of teratogenicity or impaired fertility but did show an increase in fetal resorption.",[165],{"source":32,"section":166},"Precautions\u002FWarnings – Pregnancy",{"level":159,"text":168,"quote":171,"refs":172},{"fa":169,"en":170},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","Mexiletine appears in human milk in concentrations similar to those observed in plasma.",[173],{"source":32,"section":174},"Precautions\u002FWarnings – Nursing Mothers",{"level":176,"text":177,"quote":180,"refs":181},"not-established",{"fa":178,"en":179},"برچسب: ایمنی و اثربخشی در کودکان ثابت نشده است.","Label: safety and effectiveness in children have not been established.","Safety and effectiveness in pediatric patients have not been established.",[182],{"source":32,"section":183},"Precautions\u002FWarnings – Pediatric Use",1792444411293]