[{"data":1,"prerenderedAt":172},["ShallowReactive",2],{"drug-metronidazole":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":20,"regimens":44,"contraindications":107,"warnings":131,"renal":146,"monitoring":147,"interactions":148,"review":149,"examples":152},"metronidazole",1,{"fa":7,"en":8},"مترونیدازول","Metronidazole","antiparasitic",{"fa":11,"en":12},"نیتروایمیدازول؛ ضدتک‌یاخته و ضدبی‌هوازی","Nitroimidazole antiprotozoal\u002Fantibacterial",[14],{"name":15,"market":16},"Flagyl","US",[18,19,7],"فلاژیل","flagyl",[21,35],{"id":22,"form":23,"route":24,"label":25,"concentration":26,"markets":30,"refs":31},"tab-250","tablet","oral","250 mg tablet",{"amount":27,"unit":28,"perUnit":23,"scored":29},250,"mg",false,[16],[32],{"source":33,"section":34},"fda-metronidazole-tab","Description",{"id":36,"form":23,"route":24,"label":37,"concentration":38,"markets":40,"refs":41},"tab-500","500 mg tablet",{"amount":39,"unit":28,"perUnit":23,"scored":29},500,[16],[42],{"source":33,"section":43},"How Supplied",[45,74,88],{"id":46,"disease":47,"label":48,"population":51,"type":55,"unit":28,"dose":56,"refs":60,"durationDays":65,"notes":67},"amebiasis-child","intestinal-amebiasis",{"fa":49,"en":50},"آمیبیاز (روده‌ای و آبسه کبدی) — کودکان: ۳۵ تا ۵۰ mg\u002Fkg\u002Fday در ۳ نوبت، ۱۰ روز","Amebiasis — children: 35–50 mg\u002Fkg\u002Fday in 3 doses, 10 days",{"maxAge":52},{"value":53,"unit":54},18,"year","weightBased",{"perKgPerDay":57,"perKgPerDayMax":58,"dividedDoses":59},35,50,3,[61,63],{"source":33,"section":62},"Dosage and Administration",{"source":33,"section":64},"Pediatric Use",{"min":66,"max":66},10,[68],{"text":69,"refs":72},{"fa":70,"en":71},"فقط برای آمیبیاز در کودکان بی‌خطری ثابت شده است. شکل مایع در این برچسب نیست.","In children safety is established only for amebiasis. No liquid form in this label.",[73],{"source":33,"section":64},{"id":75,"disease":47,"label":76,"population":79,"type":81,"unit":28,"dose":82,"refs":84,"durationDays":86},"amebiasis-adult",{"fa":77,"en":78},"آمیبیاز روده‌ای حاد — بزرگسال: ۷۵۰ mg سه بار در روز","Acute intestinal amebiasis — adults: 750 mg three times daily",{"minAge":80},{"value":53,"unit":54},"fixed",{"perDose":83,"dosesPerDay":59},750,[85],{"source":33,"section":62},{"min":87,"max":66},5,{"id":89,"disease":90,"label":91,"population":94,"type":55,"unit":28,"dose":96,"refs":99,"limits":101,"durationDays":105},"anaerobic-adult","serious-anaerobic-infection",{"fa":92,"en":93},"عفونت بی‌هوازی جدی — بزرگسال: ۷٫۵ mg\u002Fkg هر ۶ ساعت","Serious anaerobic infection — adults: 7.5 mg\u002Fkg every 6 h",{"minAge":95},{"value":53,"unit":54},{"perKgPerDose":97,"intervalHours":98},7.5,6,[100],{"source":33,"section":62},{"maxPerDay":102,"refs":103},4000,[104],{"source":33,"section":62},{"min":106,"max":66},7,[108,117,124],{"id":109,"severity":110,"text":111,"refs":114},"hypersensitivity","block",{"fa":112,"en":113},"حساسیت به مترونیدازول یا سایر نیتروایمیدازول‌ها.","Hypersensitivity to metronidazole or other nitroimidazoles.",[115],{"source":33,"section":116},"Contraindications",{"id":118,"severity":110,"text":119,"refs":122},"disulfiram-alcohol",{"fa":120,"en":121},"مصرف دی‌سولفیرام در ۲ هفته اخیر؛ الکل یا پروپیلن گلیکول تا ۳ روز پس از درمان.","Disulfiram within the last two weeks; alcohol or propylene glycol during and for 3 days after therapy.",[123],{"source":33,"section":116},{"id":125,"severity":110,"text":126,"refs":129},"cockayne",{"fa":127,"en":128},"سندرم کاکاین (نارسایی کبدی کشنده).","Cockayne syndrome (fatal hepatotoxicity).",[130],{"source":33,"section":116},[132,139],{"text":133,"refs":136},{"fa":134,"en":135},"هشدار جعبه‌ای: در موش و رت سرطان‌زا؛ از مصرف غیرضروری پرهیز شود.","Boxed warning: carcinogenic in mice and rats; avoid unnecessary use.",[137],{"source":33,"section":138},"WARNING (boxed)",{"text":140,"refs":143},{"fa":141,"en":142},"واکنش‌های شدید پوستی (SJS، TEN، DRESS)؛ انسفالوپاتی و نوروپاتی محیطی؛ تشنج.","Severe cutaneous reactions (SJS, TEN, DRESS); encephalopathy and peripheral neuropathy; seizures.",[144],{"source":33,"section":145},"Warnings",[],[],[],{"status":150,"reviewer":151,"date":151},"unverified",null,[153,157,163,168],{"regimen":46,"formulation":22,"input":154,"expect":155},{"ageYears":87,"weightKg":53},{"status":156},"blocked",{"regimen":46,"formulation":22,"input":158,"expect":161},{"ageYears":159,"weightKg":160},8,21.4,{"perDose":162,"tabletsPerDoseRounded":5},249.67,{"regimen":75,"formulation":22,"input":164,"expect":167},{"ageYears":165,"weightKg":166},30,70,{"tabletsPerDoseRounded":59},{"regimen":89,"formulation":36,"input":169,"expect":170},{"ageYears":165,"weightKg":166},{"perDose":171},525,1792078538078]