[{"data":1,"prerenderedAt":200},["ShallowReactive",2],{"drug-methyldopa":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":22,"regimens":45,"contraindications":92,"warnings":102,"renal":103,"monitoring":104,"interactions":112,"review":113,"examples":116,"atc":126,"iran":128,"links":144,"populations":161,"usApproval":195},"methyldopa",1,{"fa":7,"en":8},"متیل‌دوپا","Methyldopa","cardiovascular",{"fa":11,"en":12},"آگونیست آلفا-۲ مرکزی","Central alpha-2 agonist",[14],{"name":15,"market":16},"Aldomet","US",[18,19,20,21],"aldomet","آلدومت","متیل دوپا","فشار بارداری",[23,37],{"id":24,"form":25,"route":26,"label":27,"concentration":28,"markets":32,"refs":33},"tab-250","tablet","oral","250 mg tablet",{"amount":29,"unit":30,"perUnit":25,"scored":31},250,"mg",false,[16],[34],{"source":35,"section":36},"fda-methyldopa","How Supplied",{"id":38,"form":25,"route":26,"label":39,"concentration":40,"markets":42,"refs":43},"tab-500","500 mg tablet",{"amount":41,"unit":30,"perUnit":25,"scored":31},500,[16],[44],{"source":35,"section":36},[46,74],{"id":47,"disease":48,"label":49,"population":52,"type":56,"unit":30,"dose":57,"refs":59,"limits":62,"notes":67},"adult","hypertension",{"fa":50,"en":51},"فشار خون — شروع ۲۵۰ mg دو تا سه بار در روز","Hypertension — start 250 mg two to three times daily",{"minAge":53},{"value":54,"unit":55},18,"year","fixed",{"perDose":29,"dosesPerDay":58},3,[60],{"source":35,"section":61},"Dosage and Administration — Adults",{"maxPerDay":63,"refs":64},3000,[65],{"source":35,"section":66},"Dosage and Administration — Maintenance",[68],{"text":69,"refs":72},{"fa":70,"en":71},"نگهدارنده ۵۰۰ mg تا ۲ گرم در ۲ تا ۴ دوز؛ حداکثر ۳ گرم در روز.","Maintenance 500 mg–2 g in 2–4 doses; max 3 g\u002Fday.",[73],{"source":35,"section":66},{"id":75,"disease":48,"label":76,"population":79,"type":81,"unit":30,"dose":82,"refs":85,"limits":88},"child",{"fa":77,"en":78},"کودکان — ۱۰ mg\u002Fkg\u002Fروز در ۲ تا ۴ دوز","Children — 10 mg\u002Fkg\u002Fday in 2–4 doses",{"maxAge":80},{"value":54,"unit":55},"weightBased",{"perKgPerDay":83,"dividedDoses":84},10,2,[86],{"source":35,"section":87},"Dosage and Administration — Pediatric Patients",{"maxPerKgPerDay":89,"maxPerDay":63,"refs":90},65,[91],{"source":35,"section":87},[93],{"id":94,"severity":95,"text":96,"refs":99},"ci","block",{"fa":97,"en":98},"بیماری فعال کبد (هپاتیت حاد، سیروز فعال)؛ اختلال کبدی قبلی با متیل‌دوپا؛ مصرف مهارکننده MAO؛ حساسیت.","Active liver disease (acute hepatitis, active cirrhosis); previous methyldopa liver disorder; MAO inhibitors; hypersensitivity.",[100],{"source":35,"section":101},"Contraindications",[],[],[105],{"text":106,"refs":109},{"fa":107,"en":108},"آزمون کومبس مثبت و کم‌خونی همولیتیک؛ آزمایش کبد در هفته‌های اول.","Positive Coombs test and haemolytic anaemia; liver tests in the first weeks.",[110],{"source":35,"section":111},"Warnings",[],{"status":114,"reviewer":115,"date":115},"unverified",null,[117,121],{"regimen":47,"formulation":24,"input":118,"expect":120},{"ageYears":119,"weightKg":89},30,{"perDose":29,"tabletsPerDoseRounded":5},{"regimen":75,"formulation":24,"input":122,"expect":125},{"ageYears":123,"weightKg":124},12,50,{"perDose":29,"tabletsPerDoseRounded":5},[127],"C02AB01",{"status":129,"forms":130,"refs":139},"registered",[131,135],{"code":132,"en":133,"fa":134},"11408","METHYL DOPA 500MG TAB","قرص متیل دوپا ۵۰۰ میلی‌گرم",{"code":136,"en":137,"fa":138},"00832","METHYLDOPA 250MG TAB","قرص متیل‌دوپا ۲۵۰ میلی‌گرم",[140],{"source":141,"section":142,"url":143},"darooyab-generic","G-1761\u002FMethyldopa","https:\u002F\u002Fwww.darooyab.ir\u002FG-1761\u002FMethyldopa",[145,149,153,156,159],{"kind":146,"url":147,"label":148},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=070076","ANDA070076",{"kind":150,"url":151,"label":152},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=9e22e1d8-04ec-4b67-92ea-b09c706f2703","FDA Methyldopa",{"kind":154,"url":155,"label":8},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa682242.html",{"kind":157,"url":158,"label":127},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=C02AB01",{"kind":160,"url":143,"label":8},"darooyab",{"pregnancy":162,"lactation":171,"pediatric":179,"geriatric":187},{"level":163,"text":164,"quote":167,"refs":168},"caution",{"fa":165,"en":166},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","Because animal reproduction studies are not always predictive of human response, methyldopa should be used during pregnancy only if clearly needed.",[169],{"source":35,"section":170},"Pregnancy",{"level":163,"text":172,"quote":175,"refs":176},{"fa":173,"en":174},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","Therefore, caution should be exercised when methyldopa is given to a nursing woman.",[177],{"source":35,"section":178},"Nursing Mothers",{"level":163,"text":180,"quote":183,"refs":184},{"fa":181,"en":182},"برچسب برای کودکان شرط، محدودیت سنی یا نکته دارد؛ جمله برچسب در زیر آمده است.","The label has conditions, age limits or notes for children; the label sentence is quoted below.","There are no well-controlled clinical trials in pediatric patients.",[185],{"source":35,"section":186},"Pediatric Use",{"level":163,"text":188,"quote":191,"refs":192},{"fa":189,"en":190},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","Because elderly patients are more likely to have decreased renal function, care should be taken in dose selection and it may be useful to monitor renal function.",[193],{"source":35,"section":194},"Geriatric Use",{"kind":196,"refs":197,"id":148},"ANDA",[198],{"source":35,"section":199},"SPL approval \u002F marketing category",1792092039403]