[{"data":1,"prerenderedAt":161},["ShallowReactive",2],{"drug-metformin":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":19,"regimens":51,"contraindications":102,"warnings":121,"renal":129,"monitoring":146,"interactions":147,"review":148,"examples":151},"metformin",1,{"fa":7,"en":8},"متفورمین","Metformin","endocrine",{"fa":11,"en":12},"بیگوانید","Biguanide",[14],{"name":15,"market":16},"Glucophage","US",[4,7,18],"گلوکوفاژ",[20,34,42],{"id":21,"form":22,"route":23,"label":24,"concentration":25,"markets":29,"refs":30},"tab-500","tablet","oral","500 mg tablet",{"amount":26,"unit":27,"perUnit":22,"scored":28},500,"mg",false,[16],[31],{"source":32,"section":33},"fda-metformin","3",{"id":35,"form":22,"route":23,"label":36,"concentration":37,"markets":39,"refs":40},"tab-850","850 mg tablet",{"amount":38,"unit":27,"perUnit":22,"scored":28},850,[16],[41],{"source":32,"section":33},{"id":43,"form":22,"route":23,"label":44,"concentration":45,"markets":48,"refs":49},"tab-1000","1000 mg tablet",{"amount":46,"unit":27,"perUnit":22,"scored":47},1000,true,[16],[50],{"source":32,"section":33},[52,82],{"id":53,"disease":54,"label":55,"population":58,"type":64,"unit":27,"dose":65,"refs":70,"notes":75},"child","type-2-diabetes",{"fa":56,"en":57},"کودکان ۱۰ سال به بالا — شروع ۵۰۰ mg دو بار در روز","Children ≥10 years — start 500 mg twice daily",{"minAge":59,"maxAge":62},{"value":60,"unit":61},10,"year",{"value":63,"unit":61},17,"titration",{"dividedDoses":66,"titration":67},2,{"start":46,"increment":26,"incrementEveryDays":68,"max":69},7,2000,[71,73],{"source":32,"section":72},"2.2",{"source":32,"section":74},"8.4",[76],{"text":77,"refs":80},{"fa":78,"en":79},"همراه غذا؛ افزایش هفتگی ۵۰۰ mg بر اساس قند و تحمل، حداکثر ۲۰۰۰ mg\u002Fday در دو نوبت.","With meals; increase by 500 mg weekly per glycemic control and tolerability, max 2000 mg\u002Fday in two doses.",[81],{"source":32,"section":72},{"id":83,"disease":54,"label":84,"population":87,"type":64,"unit":27,"dose":89,"refs":92,"notes":95},"adult",{"fa":85,"en":86},"بزرگسال — شروع ۵۰۰ mg دو بار در روز","Adults — start 500 mg twice daily",{"minAge":88},{"value":63,"unit":61},{"dividedDoses":66,"titration":90},{"start":46,"increment":26,"incrementEveryDays":68,"max":91},2550,[93],{"source":32,"section":94},"2.1",[96],{"text":97,"refs":100},{"fa":98,"en":99},"یا ۸۵۰ mg یک‌بار در روز؛ افزایش ۵۰۰ mg هفتگی یا ۸۵۰ mg هر ۲ هفته؛ حداکثر ۲۵۵۰ mg\u002Fday. بالای ۲۰۰۰ mg بهتر در ۳ نوبت.","Or 850 mg once daily; increase 500 mg weekly or 850 mg every 2 weeks; max 2550 mg\u002Fday; above 2000 mg better tolerated in 3 doses.",[101],{"source":32,"section":94},[103,112],{"id":104,"severity":105,"text":106,"refs":109},"renal","block",{"fa":107,"en":108},"نارسایی شدید کلیه (eGFR کمتر از ۳۰)؛ اسیدوز متابولیک یا کتواسیدوز؛ حساسیت.","Severe renal impairment (eGFR \u003C30); metabolic acidosis incl. DKA; hypersensitivity.",[110],{"source":32,"section":111},"4",{"id":113,"severity":105,"rule":114,"text":116,"refs":119},"under-10",{"maxAge":115},{"value":60,"unit":61},{"fa":117,"en":118},"بی‌خطری زیر ۱۰ سال ثابت نشده است.","Not established under 10 years.",[120],{"source":32,"section":74},[122],{"text":123,"refs":126},{"fa":124,"en":125},"هشدار جعبه‌ای: اسیدوز لاکتیک (می‌تواند کشنده باشد).","Boxed warning: lactic acidosis (can be fatal).",[127],{"source":32,"section":128},"WARNING: LACTIC ACIDOSIS",[130,139],{"egfrBelow":131,"severity":132,"text":133,"refs":136},45,"warn",{"fa":134,"en":135},"شروع در eGFR ۳۰ تا ۴۵ توصیه نمی‌شود؛ زیر ۳۰ منع مصرف.","Initiation not recommended at eGFR 30–45; contraindicated below 30.",[137],{"source":32,"section":138},"2.3",{"egfrBelow":140,"severity":105,"text":141,"refs":144},30,{"fa":142,"en":143},"eGFR کمتر از ۳۰: منع مصرف.","eGFR \u003C30: contraindicated.",[145],{"source":32,"section":138},[],[],{"status":149,"reviewer":150,"date":150},"unverified",null,[152,157],{"regimen":53,"formulation":21,"input":153,"expect":156},{"ageYears":154,"weightKg":155},12,50,{"perDose":26,"tabletsPerDoseRounded":5},{"regimen":83,"formulation":21,"input":158,"expect":160},{"ageYears":155,"weightKg":159},80,{"perDose":26},1792078537774]