[{"data":1,"prerenderedAt":180},["ShallowReactive",2],{"drug-mesna":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":21,"regimens":46,"contraindications":67,"warnings":77,"renal":87,"monitoring":88,"interactions":89,"review":90,"examples":93,"atc":94,"iran":96,"usApproval":112,"links":118,"populations":137},"mesna",1,{"fa":7,"en":8},"مسنا","Mesna","various",{"fa":11,"en":12},"محافظ مثانه (ضد اکرولئین)","Uroprotective agent",[14],{"name":15,"market":16},"Mesnex","US",[18,19,7,20],"mesnex","uromitexan","اورومیتکسان",[22,35],{"id":23,"form":24,"route":25,"label":26,"concentration":27,"markets":30,"refs":31},"vial-100","injection","iv","100 mg\u002FmL (1 g multidose vial)",{"amount":28,"unit":29,"perVolumeMl":5},100,"mg",[16],[32],{"source":33,"section":34},"fda-mesna","3",{"id":36,"form":37,"route":38,"label":39,"concentration":40,"markets":43,"refs":44},"tab-400","tablet","oral","400 mg tablet (scored)",{"amount":41,"unit":29,"perUnit":37,"scored":42},400,true,[16],[45],{"source":33,"section":34},[47],{"id":48,"disease":49,"label":50,"population":53,"type":57,"unit":29,"dose":58,"refs":62},"ifos","hemorrhagic-cystitis-prevention",{"fa":51,"en":52},"پیشگیری از سیستیت هموراژیک ناشی از ایفوسفامید — وریدی ۲۰٪ دوز ایفوسفامید در ساعت ۰، ۴ و ۸","Prevention of ifosfamide-induced haemorrhagic cystitis — IV 20% of the ifosfamide dose at 0, 4 and 8 h",{"minAge":54},{"value":55,"unit":56},18,"year","notCalculated",{"reason":59},{"fa":60,"en":61},"دوز نسبتی از دوز ایفوسفامید است (نه وزن): وریدی ۲۰٪ (w\u002Fw) در زمان ایفوسفامید و ۴ و ۸ ساعت بعد (جمع ۶۰٪)؛ یا وریدی ۲۰٪ در ساعت ۰ و قرص ۴۰٪ در ساعت ۲ و ۶ (جمع ۱۰۰٪). هر روز ایفوسفامید تکرار. مثال برچسب: ایفوسفامید ۱٫۲ g\u002Fm² → مسنا ۲۴۰ mg\u002Fm² × ۳.","Dose is a ratio of the ifosfamide dose (not weight): IV 20% (w\u002Fw) at ifosfamide time and 4 and 8 h later (total 60%); or IV 20% at 0 h plus tablets 40% at 2 and 6 h (total 100%). Repeat each ifosfamide day. Label example: ifosfamide 1.2 g\u002Fm² → mesna 240 mg\u002Fm² × 3.",[63,65],{"source":33,"section":64},"2.1",{"source":33,"section":66},"2.2",[68],{"id":69,"severity":70,"text":71,"refs":74},"hyper","block",{"fa":72,"en":73},"حساسیت به مسنا یا اجزا از جمله بنزیل الکل.","Hypersensitivity to mesna or excipients including benzyl alcohol.",[75],{"source":33,"section":76},"4",[78],{"text":79,"refs":82},{"fa":80,"en":81},"واکنش حساسیتی؛ واکنش پوستی؛ سمیت بنزیل الکل (نوزاد)؛ کتون مثبت کاذب ادرار. هیدراتاسیون کافی و پایش هماچوری.","Hypersensitivity; dermatologic toxicity; benzyl alcohol toxicity (neonates); false-positive urine ketones. Maintain hydration and monitor for haematuria.",[83,85],{"source":33,"section":84},"5",{"source":33,"section":86},"2.3",[],[],[],{"status":91,"reviewer":92,"date":92},"unverified",null,[],[95],"V03AF01",{"status":97,"forms":98,"refs":107},"registered",[99,103],{"code":100,"en":101,"fa":102},"09601","MESNA 200MG\u002F2ML AMP","آمپول مسنا ۲۰۰ میلی‌گرم \u002F ۲ میلی‌لیتر",{"code":104,"en":105,"fa":106},"00814","MESNA 400MG\u002F4ML AMP","آمپول مسنا ۴۰۰ میلی‌گرم \u002F ۴ میلی‌لیتر",[108],{"source":109,"section":110,"url":111},"darooyab-generic","G-1963\u002FMesna","https:\u002F\u002Fwww.darooyab.ir\u002FG-1963\u002FMesna",{"kind":113,"refs":114,"id":117},"NDA",[115],{"source":33,"section":116},"SPL approval \u002F marketing category","NDA019884",[119,122,126,129,132,135],{"kind":120,"url":121,"label":117},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=019884",{"kind":123,"url":124,"label":125},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=a880160b-fa82-453a-a971-29ab897876a7","FDA Mesna",{"kind":127,"url":128,"label":8},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa613013.html",{"kind":127,"url":130,"label":131},"https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa695034.html","Mesna Injection",{"kind":133,"url":134,"label":95},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=V03AF01",{"kind":136,"url":111,"label":8},"darooyab",{"pregnancy":138,"lactation":147,"pediatric":156,"geriatric":164,"reproductive":172},{"level":139,"text":140,"quote":143,"refs":144},"caution",{"fa":141,"en":142},"برچسب: مسنا همراه ایفوسفامید یا سایر سیتوتوکسیک‌ها مصرف می‌شود؛ خطر جنینی از ایفوسفامید است (برچسب آن را ببینید).","Label: mesna is used with ifosfamide or other cytotoxics; fetal harm comes from ifosfamide (see its label).","Mesna is used in combination with ifosfamide or other cytotoxic agents. Ifosfamide can cause fetal harm when administered to a pregnant woman.",[145],{"source":33,"section":146},"8.1",{"level":148,"text":149,"quote":152,"refs":153},"avoid",{"fa":150,"en":151},"برچسب: شیردهی توصیه نمی‌شود یا باید بین دارو و شیردهی یکی انتخاب شود.","Label: breastfeeding not recommended, or choose between the drug and breastfeeding.","Because of the potential for serious adverse reactions in a breastfed child, advise lactating women not to breastfeed during treatment and for 1 week after the last dose of mesna or Ifosfamide.",[154],{"source":33,"section":155},"8.2",{"level":139,"text":157,"quote":160,"refs":161},{"fa":158,"en":159},"برچسب برای کودکان شرط، محدودیت سنی یا نکته دارد؛ جمله برچسب در زیر آمده است.","The label has conditions, age limits or notes for children; the label sentence is quoted below.","Mesna injection contains the preservative benzyl alcohol which has been associated with serious adverse reactions and death when administered intravenously to premature neonates and low birth weight infants .",[162],{"source":33,"section":163},"8.4",{"level":139,"text":165,"quote":168,"refs":169},{"fa":166,"en":167},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","In general, dose selection for an elderly patient should be cautious, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy.",[170],{"source":33,"section":171},"8.5",{"level":139,"text":173,"quote":176,"refs":177},{"fa":174,"en":175},"برچسب نکته‌ای درباره بارداری، پیشگیری یا باروری زنان و مردان دارد.","Label has advice on pregnancy testing, contraception or fertility for females and males.","Refer to the ifosfamide prescribing information for more information on contraception and effects on fertility.",[178],{"source":33,"section":179},"8.3",1792444410343]