[{"data":1,"prerenderedAt":266},["ShallowReactive",2],{"drug-meropenem":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":20,"regimens":43,"contraindications":131,"warnings":141,"renal":149,"monitoring":158,"interactions":159,"review":167,"examples":170,"atc":191,"iran":193,"links":209,"populations":227,"usApproval":261},"meropenem",1,{"fa":7,"en":8},"مروپنم","Meropenem","anti-infectives",{"fa":11,"en":12},"کارباپنم","Carbapenem",[14],{"name":15,"market":16},"Merrem","US",[18,7,19],"merrem","مروپنem",[21,35],{"id":22,"form":23,"route":24,"label":25,"concentration":26,"markets":30,"refs":31},"vial-500","powder-for-injection","iv","500 mg vial",{"amount":27,"unit":28,"perUnit":29},500,"mg","vial",[16],[32],{"source":33,"section":34},"fda-meropenem","3",{"id":36,"form":23,"route":24,"label":37,"concentration":38,"markets":40,"refs":41},"vial-1g","1 g vial",{"amount":39,"unit":28,"perUnit":29},1000,[16],[42],{"source":33,"section":34},[44,65,75,94,108],{"id":45,"disease":46,"label":47,"population":50,"type":52,"unit":28,"dose":53,"refs":55,"notes":58},"cssi","skin-soft-tissue-infection",{"fa":48,"en":49},"عفونت عارضه‌دار پوست و بافت نرم — بزرگسال ۵۰۰ mg هر ۸ ساعت","Complicated skin and skin-structure infection — adult 500 mg every 8 h",{"minWeightKg":51},50.01,"fixed",{"perDose":27,"dosesPerDay":54},3,[56],{"source":33,"section":57},"2.1",[59],{"text":60,"refs":63},{"fa":61,"en":62},"در پسودوموناس آئروژینوزا ۱ g هر ۸ ساعت.","1 g every 8 h if Pseudomonas aeruginosa is suspected or confirmed.",[64],{"source":33,"section":57},{"id":66,"disease":67,"label":68,"population":71,"type":52,"unit":28,"dose":72,"refs":73},"iai","intra-abdominal-infection",{"fa":69,"en":70},"عفونت عارضه‌دار داخل شکم — بزرگسال ۱ g هر ۸ ساعت","Complicated intra-abdominal infection — adult 1 g every 8 h",{"minWeightKg":51},{"perDose":39,"dosesPerDay":54},[74],{"source":33,"section":57},{"id":76,"disease":46,"label":77,"population":80,"type":84,"unit":28,"dose":85,"refs":88,"limits":91},"cssi-child",{"fa":78,"en":79},"عفونت عارضه‌دار پوست — کودک ۳ ماه به بالا: ۱۰ mg\u002Fkg هر ۸ ساعت (حداکثر ۵۰۰ mg)","cSSSI — child ≥3 months: 10 mg\u002Fkg every 8 h (max 500 mg)",{"minAge":81,"maxWeightKg":83},{"value":54,"unit":82},"month",50,"weightBased",{"perKgPerDose":86,"intervalHours":87},10,8,[89],{"source":33,"section":90},"2.3",{"maxPerDose":27,"refs":92},[93],{"source":33,"section":90},{"id":95,"disease":67,"label":96,"population":99,"type":84,"unit":28,"dose":101,"refs":103,"limits":105},"iai-child",{"fa":97,"en":98},"عفونت داخل شکم — کودک ۳ ماه به بالا: ۲۰ mg\u002Fkg هر ۸ ساعت (حداکثر ۱ g)","cIAI — child ≥3 months: 20 mg\u002Fkg every 8 h (max 1 g)",{"minAge":100,"maxWeightKg":83},{"value":54,"unit":82},{"perKgPerDose":102,"intervalHours":87},20,[104],{"source":33,"section":90},{"maxPerDose":39,"refs":106},[107],{"source":33,"section":90},{"id":109,"disease":110,"label":111,"population":114,"type":84,"unit":28,"dose":116,"refs":118,"limits":120,"notes":124},"mening-child","bacterial-meningitis",{"fa":112,"en":113},"مننژیت باکتریایی — کودک ۳ ماه به بالا: ۴۰ mg\u002Fkg هر ۸ ساعت (حداکثر ۲ g)","Bacterial meningitis — child ≥3 months: 40 mg\u002Fkg every 8 h (max 2 g)",{"minAge":115,"maxWeightKg":83},{"value":54,"unit":82},{"perKgPerDose":117,"intervalHours":87},40,[119],{"source":33,"section":90},{"maxPerDose":121,"refs":122},2000,[123],{"source":33,"section":90},[125],{"text":126,"refs":129},{"fa":127,"en":128},"کودک بالای ۵۰ kg: ۲ g هر ۸ ساعت.","Children over 50 kg: 2 g every 8 h.",[130],{"source":33,"section":90},[132],{"id":133,"severity":134,"text":135,"refs":138},"hyper","block",{"fa":136,"en":137},"حساسیت به دارو یا آنافیلاکسی با سایر بتالاکتام‌ها.","Hypersensitivity to the drug or anaphylaxis with other beta-lactams.",[139],{"source":33,"section":140},"4",[142],{"text":143,"refs":146},{"fa":144,"en":145},"واکنش آلرژیک جدی؛ اسهال مرتبط با کلستریدیوم دیفیسیل؛ تشنج (به‌ویژه در نارسایی کلیه).","Serious hypersensitivity; Clostridioides difficile-associated diarrhoea; seizures (especially with renal impairment).",[147],{"source":33,"section":148},"5",[150],{"egfrBelow":83,"severity":151,"text":152,"refs":155},"warn",{"fa":153,"en":154},"ClCr ۲۶ تا ۵۰: دوز معمول هر ۱۲ ساعت؛ ۱۰ تا ۲۵: نصف دوز هر ۱۲ ساعت؛ زیر ۱۰: نصف دوز هر ۲۴ ساعت.","CrCl 26–50: usual dose every 12 h; 10–25: half dose every 12 h; \u003C10: half dose every 24 h.",[156],{"source":33,"section":157},"2.2",[],[160],{"with":161,"text":162,"refs":165},"valproate",{"fa":163,"en":164},"والپروات: کاهش شدید سطح والپروات و خطر تشنج — همزمان توصیه نمی‌شود.","Valproic acid: marked fall in valproate levels and breakthrough seizures — not recommended together.",[166],{"source":33,"section":148},{"status":168,"reviewer":169,"date":169},"unverified",null,[171,175,180,184,188],{"regimen":45,"formulation":22,"input":172,"expect":174},{"ageYears":83,"weightKg":173},70,{"perDose":27,"dosesPerDay":54},{"regimen":76,"formulation":22,"input":176,"expect":178},{"ageYears":177,"weightKg":102},5,{"perDose":179},200,{"regimen":95,"formulation":36,"input":181,"expect":182},{"ageYears":177,"weightKg":102},{"perDose":183},400,{"regimen":109,"formulation":36,"input":185,"expect":186},{"ageYears":177,"weightKg":102},{"perDose":187},800,{"regimen":66,"formulation":36,"input":189,"expect":190},{"ageYears":83,"weightKg":173},{"perDose":39,"dosesPerDay":54},[192],"J01DH02",{"status":194,"forms":195,"refs":204},"registered",[196,200],{"code":197,"en":198,"fa":199},"05629","MEROPENEM 1G VIAL","ویال مروپنم ۱ گرم",{"code":201,"en":202,"fa":203},"03283","MEROPENEM 500MG VIAL","ویال مروپنم ۵۰۰ میلی‌گرم",[205],{"source":206,"section":207,"url":208},"darooyab-generic","G-433\u002FMeropenem","https:\u002F\u002Fwww.darooyab.ir\u002FG-433\u002FMeropenem",[210,214,218,222,225],{"kind":211,"url":212,"label":213},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=210773","ANDA210773",{"kind":215,"url":216,"label":217},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=74ff19b5-6156-4a27-affb-744b0ce1aeec","FDA Meropenem",{"kind":219,"url":220,"label":221},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa696038.html","Meropenem Injection",{"kind":223,"url":224,"label":192},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=J01DH02",{"kind":226,"url":208,"label":8},"darooyab",{"pregnancy":228,"lactation":237,"pediatric":245,"geriatric":253},{"level":229,"text":230,"quote":233,"refs":234},"caution",{"fa":231,"en":232},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","Risk Summary There are insufficient human data to establish whether there is a drug-associated risk of major birth defects or miscarriages with meropenem in pregnant women.",[235],{"source":33,"section":236},"8.1",{"level":229,"text":238,"quote":241,"refs":242},{"fa":239,"en":240},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","Risk Summary Meropenem has been reported to be excreted in human milk.",[243],{"source":33,"section":244},"8.2",{"level":229,"text":246,"quote":249,"refs":250},{"fa":247,"en":248},"برچسب برای کودکان شرط، محدودیت سنی یا نکته دارد؛ جمله برچسب در زیر آمده است.","The label has conditions, age limits or notes for children; the label sentence is quoted below.","The safety and effectiveness of Meropenem for injection have been established for pediatric patients 3 months of age and older with complicated skin and skin structure infections and bacterial meningitis, and for pediatric patients of all ages with complicated intra-abdominal infections.",[251],{"source":33,"section":252},"8.4",{"level":229,"text":254,"quote":257,"refs":258},{"fa":255,"en":256},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","Because elderly patients are more likely to have decreased renal function, care should be taken in dose selection, and it may be useful to monitor renal function.",[259],{"source":33,"section":260},"8.5",{"kind":262,"refs":263,"id":213},"ANDA",[264],{"source":33,"section":265},"SPL approval \u002F marketing category",1792115187885]