[{"data":1,"prerenderedAt":144},["ShallowReactive",2],{"drug-melatonin":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":20,"regimens":35,"contraindications":63,"warnings":73,"renal":80,"monitoring":81,"interactions":82,"review":83,"examples":86,"atc":92,"iran":94,"links":110,"populations":120},"melatonin",1,{"fa":7,"en":8},"ملاتونین","Melatonin","nervous-system",{"fa":11,"en":12},"آگونیست گیرنده ملاتونین","Melatonin receptor agonist",[14],{"name":15,"market":16},"Circadin","UK",[18,19,7],"circadin","سیرکادین",[21],{"id":22,"form":23,"route":24,"label":25,"concentration":26,"markets":30,"refs":31},"pr-2","tablet","oral","2 mg prolonged-release tablet (swallow whole)",{"amount":27,"unit":28,"perUnit":23,"scored":29},2,"mg",false,[16],[32],{"source":33,"section":34},"emc-circadin","6.5",[36],{"id":37,"disease":37,"label":38,"population":41,"type":45,"unit":28,"dose":46,"refs":47,"durationDays":52,"notes":54},"insomnia",{"fa":39,"en":40},"بی‌خوابی اولیه (۵۵ سال به بالا) — ۲ mg یک بار، ۱ تا ۲ ساعت پیش از خواب پس از غذا","Primary insomnia (≥55 y) — 2 mg once, 1–2 h before bedtime after food",{"minAge":42},{"value":43,"unit":44},55,"year","fixed",{"perDose":27,"dosesPerDay":5},[48,50],{"source":33,"section":49},"4.2",{"source":33,"section":51},"4.1",{"min":5,"max":53},91,[55],{"text":56,"refs":59},{"fa":57,"en":58},"تا ۱۳ هفته. قرص کامل بلعیده شود. در نارسایی کبد توصیه نمی‌شود؛ بیماری خودایمنی: توصیه نمی‌شود.","Up to 13 weeks. Swallow whole. Not recommended with hepatic impairment or autoimmune disease.",[60,61],{"source":33,"section":49},{"source":33,"section":62},"4.4",[64],{"id":65,"severity":66,"text":67,"refs":70},"hyper","block",{"fa":68,"en":69},"حساسیت به ملاتونین یا اجزای فرآورده.","Hypersensitivity to melatonin or excipients.",[71],{"source":33,"section":72},"4.3",[74],{"text":75,"refs":78},{"fa":76,"en":77},"خواب‌آلودگی؛ در رانندگی احتیاط.","Drowsiness; caution when driving.",[79],{"source":33,"section":62},[],[],[],{"status":84,"reviewer":85,"date":85},"unverified",null,[87],{"regimen":37,"formulation":22,"input":88,"expect":91},{"ageYears":89,"weightKg":90},65,70,{"perDose":27,"tabletsPerDoseRounded":5},[93],"N05CH01",{"status":95,"forms":96,"refs":105},"registered",[97,101],{"code":98,"en":99,"fa":100},"08807","MELATONIN 5MG SL TAB","قرص ملاتونین ۵ میلی‌گرم SL",{"code":102,"en":103,"fa":104},"04482","MELATONIN 3MG TAB","قرص ملاتونین ۳ میلی‌گرم",[106],{"source":107,"section":108,"url":109},"darooyab-generic","G-3997\u002FMelatonin","https:\u002F\u002Fwww.darooyab.ir\u002FG-3997\u002FMelatonin",[111,114,116],{"kind":112,"url":113,"label":93},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=N05CH01",{"kind":115,"url":109,"label":8},"darooyab",{"kind":117,"url":118,"label":119},"emc","https:\u002F\u002Fwww.medicines.org.uk\u002Femc\u002Fproduct\u002F2809\u002Fsmpc","eMC Circadin",{"pregnancy":121,"lactation":130,"pediatric":137},{"level":122,"text":123,"quote":126,"refs":127},"caution",{"fa":124,"en":125},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","For melatonin, no clinical data on exposed pregnancies are available.",[128],{"source":33,"section":129},"4.6",{"level":122,"text":131,"quote":134,"refs":135},{"fa":132,"en":133},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","Endogenous melatonin was measured in human breast milk thus exogenous melatonin is probably secreted into human milk.",[136],{"source":33,"section":129},{"level":122,"text":138,"quote":141,"refs":142},{"fa":139,"en":140},"برچسب برای کودکان شرط، محدودیت سنی یا نکته دارد؛ جمله برچسب در زیر آمده است.","The label has conditions, age limits or notes for children; the label sentence is quoted below.","Paediatric population The safety and efficacy of Circadin in children aged 0 to 18 years has not yet been established.",[143],{"source":33,"section":49},1792115187584]