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strong CYP3A4 inhibitors (ketoconazole, clarithromycin, ritonavir…); strong CYP3A4 inducers (rifampin, phenytoin, carbamazepine, St John’s wort…).",[175],{"source":33,"section":176},"4",[178,185,191],{"text":179,"refs":182},{"fa":180,"en":181},"هشدار جعبه‌ای: افزایش مرگ در سالمندان با سایکوز ناشی از دمانس.","Boxed warning: increased mortality in elderly patients with dementia-related psychosis.",[183],{"source":33,"section":184},"Boxed Warning",{"text":186,"refs":189},{"fa":187,"en":188},"هشدار جعبه‌ای: افزایش افکار و رفتار خودکشی در کودکان، نوجوانان و جوانان.","Boxed warning: increased suicidal thoughts and behaviour in children, adolescents and young adults.",[190],{"source":33,"section":184},{"text":192,"refs":195},{"fa":193,"en":194},"سندرم نورولپتیک بدخیم؛ دیسکینزی دیررس؛ تغییرات متابولیک.","Neuroleptic malignant syndrome; tardive dyskinesia; metabolic changes.",[196],{"source":33,"section":197},"5",[199],{"egfrBelow":200,"severity":201,"text":202,"refs":205},50,"warn",{"fa":203,"en":204},"ClCr زیر ۵۰: شروع ۲۰ mg، حداکثر ۸۰ mg\u002Fروز.","CrCl \u003C50: start 20 mg, max 80 mg\u002Fday.",[206],{"source":33,"section":207},"2.4",[],[210],{"with":211,"text":212,"refs":215},"cyp3a4-mod",{"fa":213,"en":214},"مهارکننده متوسط CYP3A4 (مثلاً دیلتیازم): نصف دوز؛ شروع ۲۰ mg، حداکثر ۸۰ mg.","Moderate CYP3A4 inhibitor (e.g. diltiazem): halve the dose; start 20 mg, max 80 mg.",[216],{"source":33,"section":217},"2",{"status":219,"reviewer":220,"date":220},"unverified",null,[222,227,232,237],{"regimen":69,"formulation":36,"input":223,"expect":226},{"ageYears":224,"weightKg":225},30,75,{"perDose":39,"tabletsPerDoseRounded":5},{"regimen":116,"formulation":22,"input":228,"expect":231},{"ageYears":229,"weightKg":230},35,70,{"perDose":27,"tabletsPerDoseRounded":5},{"regimen":96,"formulation":36,"input":233,"expect":236},{"ageYears":234,"weightKg":235},15,55,{"perDose":39,"tabletsPerDoseRounded":5},{"regimen":142,"formulation":22,"input":238,"expect":240},{"ageYears":239,"weightKg":39},12,{"perDose":27,"tabletsPerDoseRounded":5},[242],"N05AE05",{"status":244,"forms":245,"refs":250},"registered",[246],{"code":247,"en":248,"fa":249},"18904","LURASIDONE 40MG TAB","قرص لوراسیدون ۴۰ میلی‌گرم",[251],{"source":252,"section":253,"url":254},"darooyab-generic","G-4770\u002FLurasidone","https:\u002F\u002Fwww.darooyab.ir\u002FG-4770\u002FLurasidone",[256,260,264,267,270],{"kind":257,"url":258,"label":259},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=200603","NDA200603",{"kind":261,"url":262,"label":263},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=afad3051-9df2-4c54-9684-e8262a133af8","FDA Latuda",{"kind":265,"url":266,"label":8},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa611016.html",{"kind":268,"url":269,"label":242},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=N05AE05",{"kind":271,"url":254,"label":8},"darooyab",{"pregnancy":273,"lactation":282,"pediatric":290,"geriatric":298},{"level":274,"text":275,"quote":278,"refs":279},"caution",{"fa":276,"en":277},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","Risk Summary Neonates exposed to antipsychotic drugs during the third trimester of pregnancy are at risk for extrapyramidal and\u002For withdrawal symptoms following delivery [see Clinical Considerations ] .",[280],{"source":33,"section":281},"8.1",{"level":274,"text":283,"quote":286,"refs":287},{"fa":284,"en":285},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","Risk Summary Lactation studies have not been conducted to assess the presence of lurasidone in human milk, the effects on the breastfed infant, or the effects on milk production.",[288],{"source":33,"section":289},"8.2",{"level":291,"text":292,"quote":295,"refs":296},"avoid",{"fa":293,"en":294},"هشدار جعبه‌ای برچسب درباره کودکان.","Boxed warning in the label about children.","Antidepressants increased the risk of suicidal thoughts and behavior in pediatric and young adult patients.",[297],{"source":33,"section":184},{"level":291,"text":299,"quote":302,"refs":303},{"fa":300,"en":301},"برچسب: در سالمندان هشدار جدی یا پرهیز.","Label: serious warning or avoid in older adults.","WARNING: INCREASED MORTALITY IN ELDERLY PATIENTS WITH DEMENTIA-RELATED PSYCHOSIS; and SUICIDAL THOUGHTS AND BEHAVIORS See full prescribing information for complete boxed warning.",[304],{"source":33,"section":184},{"kind":306,"refs":307,"id":259},"NDA",[308],{"source":33,"section":309},"SPL approval \u002F marketing category",1792115186984]