[{"data":1,"prerenderedAt":184},["ShallowReactive",2],{"drug-loxapine":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":19,"regimens":58,"contraindications":86,"warnings":96,"renal":104,"monitoring":105,"interactions":106,"review":107,"examples":110,"atc":117,"iran":119,"links":126,"populations":143,"usApproval":179},"loxapine",1,{"fa":7,"en":8},"لوکساپین","Loxapine","nervous-system",{"fa":11,"en":12},"دی‌بنزوکسازپین (ضدروان‌پریشی تیپیک)","Dibenzoxazepine (typical antipsychotic)",[14],{"name":15,"market":16},"Loxitane","US",[18,7],"loxitane",[20,34,42,50],{"id":21,"form":22,"route":23,"label":24,"concentration":25,"markets":29,"refs":30},"cap-10","capsule","oral","10 mg capsule",{"amount":26,"unit":27,"perUnit":22,"scored":28},10,"mg",false,[16],[31],{"source":32,"section":33},"fda-loxapine","How Supplied",{"id":35,"form":22,"route":23,"label":36,"concentration":37,"markets":39,"refs":40},"cap-25","25 mg capsule",{"amount":38,"unit":27,"perUnit":22,"scored":28},25,[16],[41],{"source":32,"section":33},{"id":43,"form":22,"route":23,"label":44,"concentration":45,"markets":47,"refs":48},"cap-5","5 mg capsule",{"amount":46,"unit":27,"perUnit":22,"scored":28},5,[16],[49],{"source":32,"section":33},{"id":51,"form":22,"route":23,"label":52,"concentration":53,"markets":55,"refs":56},"cap-50","50 mg capsule",{"amount":54,"unit":27,"perUnit":22,"scored":28},50,[16],[57],{"source":32,"section":33},[59],{"id":60,"disease":61,"label":62,"population":65,"type":69,"unit":27,"dose":70,"refs":72,"limits":75,"notes":79},"scz","schizophrenia",{"fa":63,"en":64},"اسکیزوفرنی بزرگسال — شروع ۱۰ mg دو بار در روز","Schizophrenia, adults — start 10 mg twice daily",{"minAge":66},{"value":67,"unit":68},18,"year","fixed",{"perDose":26,"dosesPerDay":71},2,[73],{"source":32,"section":74},"Dosage and Administration",{"maxPerDay":76,"refs":77},250,[78],{"source":32,"section":74},[80],{"text":81,"refs":84},{"fa":82,"en":83},"افزایش طی ۷ تا ۱۰ روز؛ محدوده معمول ۶۰ تا ۱۰۰ mg\u002Fروز در ۲ تا ۴ دوز؛ بیش از ۲۵۰ mg\u002Fروز نه. نگهدارنده اغلب ۲۰ تا ۶۰ mg\u002Fروز.","Increase over 7–10 days; usual range 60–100 mg\u002Fday in 2–4 doses; not above 250 mg\u002Fday. Maintenance often 20–60 mg\u002Fday.",[85],{"source":32,"section":74},[87],{"id":88,"severity":89,"text":90,"refs":93},"ci","block",{"fa":91,"en":92},"کما یا افسردگی شدید ناشی از دارو (الکل، باربیتورات، مخدر)؛ حساسیت به دی‌بنزوکسازپین‌ها.","Coma or severe drug-induced depressed states (alcohol, barbiturates, opioids); hypersensitivity to dibenzoxazepines.",[94],{"source":32,"section":95},"Contraindications",[97],{"text":98,"refs":101},{"fa":99,"en":100},"هشدار جعبه‌ای: افزایش مرگ در سالمندان مبتلا به سایکوز ناشی از دمانس — برای این کاربرد تأیید نشده.","Boxed warning: increased mortality in elderly patients with dementia-related psychosis — not approved for this use.",[102],{"source":32,"section":103},"Warnings",[],[],[],{"status":108,"reviewer":109,"date":109},"unverified",null,[111],{"regimen":60,"formulation":21,"input":112,"expect":115},{"ageYears":113,"weightKg":114},35,70,{"perDose":26,"tabletsPerDoseRounded":5,"perDay":116},20,[118],"N05AH01",{"status":120,"refs":121},"not-found",[122],{"source":123,"section":124,"url":125},"darooyab-generic","G-1297\u002FLoxapine","https:\u002F\u002Fwww.darooyab.ir\u002FG-1297\u002FLoxapine",[127,131,135,138,141],{"kind":128,"url":129,"label":130},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=072204","ANDA072204",{"kind":132,"url":133,"label":134},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=a6107bb1-3e23-4c5d-bbf4-5e29deff6728","FDA Loxapine",{"kind":136,"url":137,"label":8},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa682311.html",{"kind":139,"url":140,"label":118},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=N05AH01",{"kind":142,"url":125,"label":8},"darooyab",{"pregnancy":144,"lactation":153,"pediatric":161,"geriatric":170},{"level":145,"text":146,"quote":149,"refs":150},"caution",{"fa":147,"en":148},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","Loxapine succinate should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.",[151],{"source":32,"section":152},"Pregnancy",{"level":145,"text":154,"quote":157,"refs":158},{"fa":155,"en":156},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","The extent of the excretion of loxapine or its metabolites in human milk is not known.",[159],{"source":32,"section":160},"Nursing Mothers",{"level":162,"text":163,"quote":166,"refs":167},"not-established",{"fa":164,"en":165},"برچسب: ایمنی و اثربخشی در کودکان ثابت نشده است.","Label: safety and effectiveness in children have not been established.","Safety and effectiveness of loxapine in pediatric patients have not been established.",[168],{"source":32,"section":169},"Pediatric Use",{"level":171,"text":172,"quote":175,"refs":176},"avoid",{"fa":173,"en":174},"برچسب: در سالمندان هشدار جدی یا پرهیز.","Label: serious warning or avoid in older adults.","Increased Mortality in Elderly Patients with Dementia-Related Psychosis Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death.",[177],{"source":32,"section":178},"Boxed Warning",{"kind":180,"refs":181,"id":130},"ANDA",[182],{"source":32,"section":183},"SPL approval \u002F marketing category",1792191553284]