[{"data":1,"prerenderedAt":167},["ShallowReactive",2],{"drug-lithium":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":20,"regimens":52,"contraindications":108,"warnings":128,"renal":136,"monitoring":137,"interactions":147,"review":148,"examples":151},"lithium",1,{"fa":7,"en":8},"لیتیوم","Lithium carbonate","psychiatry",{"fa":11,"en":12},"تثبیت‌کننده خلق","Mood stabilizer",[14],{"name":15,"market":16},"Lithobid","US",[18,4,19],"لیتیم","کربنات لیتیوم",[21,35,45],{"id":22,"form":23,"route":24,"label":25,"concentration":26,"markets":30,"refs":31},"tab-300","tablet","oral","300 mg tablet (scored)",{"amount":27,"unit":28,"perUnit":23,"scored":29},300,"mg",true,[16],[32],{"source":33,"section":34},"fda-lithium","3",{"id":36,"form":37,"route":24,"label":38,"concentration":39,"markets":42,"refs":43},"cap-150","capsule","150 mg capsule",{"amount":40,"unit":28,"perUnit":37,"scored":41},150,false,[16],[44],{"source":33,"section":34},{"id":46,"form":37,"route":24,"label":47,"concentration":48,"markets":49,"refs":50},"cap-300","300 mg capsule",{"amount":27,"unit":28,"perUnit":37,"scored":41},[16],[51],{"source":33,"section":34},[53,83],{"id":54,"disease":55,"label":56,"population":59,"type":64,"unit":28,"dose":65,"refs":71,"notes":74},"over30","bipolar-mania",{"fa":57,"en":58},"دوقطبی نوع ۱ — بزرگسال و کودک بالای ۳۰ kg: شروع ۳۰۰ mg سه بار در روز","Bipolar I — adults and children >30 kg: start 300 mg three times daily",{"minAge":60,"minWeightKg":63},{"value":61,"unit":62},7,"year",30.01,"titration",{"dividedDoses":66,"titration":67},3,{"start":68,"increment":27,"incrementEveryDays":66,"targetMin":69,"targetMax":70,"max":70},900,1200,1800,[72],{"source":33,"section":73},"2.2, Table 1",[75],{"text":76,"refs":79},{"fa":77,"en":78},"هدف حاد: ۶۰۰ mg دو تا سه بار در روز (سطح ۰٫۸ تا ۱٫۲ mEq\u002FL)؛ نگهدارنده ۳۰۰ تا ۶۰۰ mg دو تا سه بار در روز (۰٫۸ تا ۱٫۰). سطح سرمی ۳ روز بعد، ۱۲ ساعت پس از دوز.","Acute goal: 600 mg 2–3 times daily (0.8–1.2 mEq\u002FL); maintenance 300–600 mg 2–3 times daily (0.8–1.0). Check serum level after 3 days, 12 h post-dose.",[80,81],{"source":33,"section":73},{"source":33,"section":82},"2.2",{"id":84,"disease":55,"label":85,"population":88,"type":64,"unit":28,"dose":94,"refs":99,"notes":101},"20-30kg",{"fa":86,"en":87},"دوقطبی نوع ۱ — کودک ۲۰ تا ۳۰ kg: شروع ۳۰۰ mg دو بار در روز","Bipolar I — children 20–30 kg: start 300 mg twice daily",{"minAge":89,"maxAge":90,"minWeightKg":92,"maxWeightKg":93},{"value":61,"unit":62},{"value":91,"unit":62},18,20,30,{"dividedDoses":95,"titration":96},2,{"start":97,"increment":27,"incrementEveryDays":61,"targetMin":97,"targetMax":98,"max":98},600,1500,[100],{"source":33,"section":73},[102],{"text":103,"refs":106},{"fa":104,"en":105},"حاد: ۶۰۰ تا ۱۵۰۰ mg\u002Fday منقسم؛ نگهدارنده ۶۰۰ تا ۱۲۰۰ mg\u002Fday.","Acute: 600–1500 mg\u002Fday divided; maintenance 600–1200 mg\u002Fday.",[107],{"source":33,"section":73},[109,120],{"id":110,"severity":111,"rule":112,"text":114,"refs":117},"under-7","block",{"maxAge":113},{"value":61,"unit":62},{"fa":115,"en":116},"بی‌خطری زیر ۷ سال ثابت نشده است.","Not established under 7 years.",[118],{"source":33,"section":119},"8.4",{"id":121,"severity":111,"text":122,"refs":125},"hypersensitivity",{"fa":123,"en":124},"حساسیت به اجزای فرآورده.","Hypersensitivity to any inactive ingredient.",[126],{"source":33,"section":127},"4",[129],{"text":130,"refs":133},{"fa":131,"en":132},"هشدار جعبه‌ای: مسمومیت لیتیوم نزدیک به سطوح درمانی رخ می‌دهد؛ امکان اندازه‌گیری سطح سرمی پیش از شروع لازم است.","Boxed warning: lithium toxicity can occur close to therapeutic levels; serum level testing must be available before starting.",[134],{"source":33,"section":135},"WARNING: LITHIUM TOXICITY",[],[138],{"text":139,"refs":142},{"fa":140,"en":141},"پیش از شروع: کلیه، علائم حیاتی، الکترولیت، تیروئید، بارداری. سطح سرمی پس از هر تغییر دوز یا داروهای همراه (دیورتیک، NSAID، ARB\u002FACEI، مترونیدازول).","Before start: renal function, vitals, electrolytes, thyroid, pregnancy. Check serum level after any dose change or new interacting drug (diuretics, NSAIDs, RAS antagonists, metronidazole).",[143,145],{"source":33,"section":144},"2.1",{"source":33,"section":146},"2.3",[],{"status":149,"reviewer":150,"date":150},"unverified",null,[152,156,161],{"regimen":54,"formulation":22,"input":153,"expect":155},{"ageYears":93,"weightKg":154},70,{"perDose":27,"tabletsPerDoseRounded":5},{"regimen":84,"formulation":22,"input":157,"expect":160},{"ageYears":158,"weightKg":159},9,25,{"perDose":27},{"regimen":54,"formulation":22,"input":162,"expect":165},{"ageYears":163,"weightKg":164},6,35,{"status":166},"blocked",1792078537247]