[{"data":1,"prerenderedAt":214},["ShallowReactive",2],{"drug-linezolid":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":20,"regimens":35,"contraindications":76,"warnings":86,"renal":94,"monitoring":95,"interactions":96,"review":104,"examples":107,"atc":113,"iran":115,"links":147,"populations":167,"usApproval":209},"linezolid",1,{"fa":7,"en":8},"لاینزولید","Linezolid","anti-infectives",{"fa":11,"en":12},"اکسازولیدینون","Oxazolidinone",[14],{"name":15,"market":16},"Zyvox","US",[18,7,19],"zyvox","لینزولید",[21],{"id":22,"form":23,"route":24,"label":25,"concentration":26,"markets":30,"refs":31},"tab-600","tablet","oral","600 mg tablet",{"amount":27,"unit":28,"perUnit":23,"scored":29},600,"mg",false,[16],[32],{"source":33,"section":34},"fda-linezolid","3",[36,62],{"id":37,"disease":38,"label":39,"population":42,"type":46,"unit":28,"dose":47,"refs":49,"durationDays":52,"notes":55},"adult","hospital-acquired-pneumonia",{"fa":40,"en":41},"پنومونی بیمارستانی یا اکتسابی، عفونت عارضه‌دار پوست، VRE — ۱۲ سال به بالا ۶۰۰ mg هر ۱۲ ساعت","Nosocomial or community pneumonia, cSSSI, VRE — ≥12 y 600 mg every 12 h",{"minAge":43},{"value":44,"unit":45},12,"year","fixed",{"perDose":27,"dosesPerDay":48},2,[50],{"source":33,"section":51},"2.1",{"min":53,"max":54},10,14,[56],{"text":57,"refs":60},{"fa":58,"en":59},"VRE: ۱۴ تا ۲۸ روز. عفونت پوستی بدون عارضه بزرگسال: ۴۰۰ mg هر ۱۲ ساعت (قرص ۴۰۰ در این برچسب نیست).","VRE: 14–28 days. Uncomplicated SSSI in adults: 400 mg every 12 h (no 400 mg tablet in this label).",[61],{"source":33,"section":51},{"id":63,"disease":38,"label":64,"population":67,"type":69,"unit":28,"dose":70,"refs":74},"child",{"fa":65,"en":66},"کودک زیر ۱۲ سال — ۱۰ mg\u002Fkg هر ۸ ساعت (فرم مایع)","Child \u003C12 y — 10 mg\u002Fkg every 8 h (liquid form)",{"maxAge":68},{"value":44,"unit":45},"notCalculated",{"reason":71},{"fa":72,"en":73},"برچسب: ۱۰ mg\u002Fkg هر ۸ ساعت (عفونت پوستی بدون عارضه: زیر ۵ سال هر ۸ و ۵ تا ۱۱ سال هر ۱۲ ساعت). این برچسب فقط قرص ۶۰۰ mg دارد؛ برای کودک از سوسپانسیون استفاده شود.","Label: 10 mg\u002Fkg every 8 h (uncomplicated SSSI: \u003C5 y every 8 h, 5–11 y every 12 h). This label only has the 600 mg tablet; children need the oral suspension.",[75],{"source":33,"section":51},[77],{"id":78,"severity":79,"text":80,"refs":83},"ci","block",{"fa":81,"en":82},"حساسیت به لاینزولید؛ مصرف MAOI یا ظرف ۲ هفته پس از آن.","Hypersensitivity to linezolid; MAOIs now or within 2 weeks.",[84],{"source":33,"section":85},"4",[87],{"text":88,"refs":91},{"fa":89,"en":90},"سرکوب مغز استخوان (CBC هفتگی)؛ سندرم سروتونین با داروهای سروتونرژیک؛ نوروپاتی محیطی و بینایی در مصرف بیش از ۲۸ روز؛ اسیدوز لاکتیک؛ هیپوگلیسمی.","Myelosuppression (weekly CBC); serotonin syndrome with serotonergic drugs; peripheral and optic neuropathy beyond 28 days; lactic acidosis; hypoglycaemia.",[92],{"source":33,"section":93},"5",[],[],[97],{"with":98,"text":99,"refs":102},"ssri",{"fa":100,"en":101},"SSRI، SNRI، تریپتان‌ها و سایر داروهای سروتونرژیک: سندرم سروتونین.","SSRIs, SNRIs, triptans and other serotonergic drugs: serotonin syndrome.",[103],{"source":33,"section":93},{"status":105,"reviewer":106,"date":106},"unverified",null,[108],{"regimen":37,"formulation":22,"input":109,"expect":112},{"ageYears":110,"weightKg":111},50,70,{"perDose":27,"tabletsPerDoseRounded":5},[114],"J01XX08",{"status":116,"forms":117,"refs":142},"registered",[118,122,126,130,134,138],{"code":119,"en":120,"fa":121},"09250","LINEZOLID 2mg\u002Fml 300ML SOLUTION","محلول لاینزولید ۲ میلی‌گرم \u002F میلی‌لیتر ۳۰۰ میلی‌لیتر",{"code":123,"en":124,"fa":125},"21942","LINEZOLID 400MG TAB","قرص لاینزولید ۴۰۰ میلی‌گرم",{"code":127,"en":128,"fa":129},"08301","LINEZOLID 600MG INJ","فرآورده تزریقی لاینزولید ۶۰۰ میلی‌گرم",{"code":131,"en":132,"fa":133},"08300","LINEZOLID 600MG TAB","قرص لاینزولید ۶۰۰ میلی‌گرم",{"code":135,"en":136,"fa":137},"50114","LINEZOLID INJECTION, SOLUTION PARENTERAL 2 mg\u002F1mL 300 mL","محلول تزریقی لاینزولید ۲ میلی‌گرم \u002F ۱ میلی‌لیتر ۳۰۰ میلی‌لیتر",{"code":139,"en":140,"fa":141},"52928","LINEZOLID INJECTION, SOLUTION PARENTERAL 2 mg\u002F1mL 100 mL","محلول تزریقی لاینزولید ۲ میلی‌گرم \u002F ۱ میلی‌لیتر ۱۰۰ میلی‌لیتر",[143],{"source":144,"section":145,"url":146},"darooyab-generic","G-423\u002FLinezolid","https:\u002F\u002Fwww.darooyab.ir\u002FG-423\u002FLinezolid",[148,152,156,159,162,165],{"kind":149,"url":150,"label":151},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=078845","ANDA078845",{"kind":153,"url":154,"label":155},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=bf4fa35d-93c9-41c3-a2ae-0298014b8a9f","FDA Linezolid tab",{"kind":157,"url":158,"label":8},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa602004.html",{"kind":157,"url":160,"label":161},"https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa612002.html","Linezolid Injection",{"kind":163,"url":164,"label":114},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=J01XX08",{"kind":166,"url":146,"label":8},"darooyab",{"pregnancy":168,"lactation":177,"pediatric":185,"geriatric":193,"reproductive":201},{"level":169,"text":170,"quote":173,"refs":174},"caution",{"fa":171,"en":172},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","Risk Summary Available data from published and postmarketing case reports with linezolid use in pregnant women have not identified a drug-associated risk of major birth defects, miscarriage, or adverse maternal or fetal outcomes.",[175],{"source":33,"section":176},"8.1",{"level":169,"text":178,"quote":181,"refs":182},{"fa":179,"en":180},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","Risk Summary Linezolid is present in breast milk.",[183],{"source":33,"section":184},"8.2",{"level":169,"text":186,"quote":189,"refs":190},{"fa":187,"en":188},"برچسب برای کودکان شرط، محدودیت سنی یا نکته دارد؛ جمله برچسب در زیر آمده است.","The label has conditions, age limits or notes for children; the label sentence is quoted below.","… y in patients ranging in age from 8 months through 12 years) • vancomycin-resistant Enterococcus faecium infections The safety and effectiveness of linezolid for the treatment of pediatric patients with the following infection have been established in a comparator-controlled study in pediatric patients ranging in …",[191],{"source":33,"section":192},"8.4",{"level":169,"text":194,"quote":197,"refs":198},{"fa":195,"en":196},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","Of the 2,046 patients treated with linezolid in Phase 3 comparator-controlled clinical trials, 589 (29%) were 65 years or older and 253 (12%) were 75 years or older.",[199],{"source":33,"section":200},"8.5",{"level":169,"text":202,"quote":205,"refs":206},{"fa":203,"en":204},"برچسب نکته‌ای درباره بارداری، پیشگیری یا باروری زنان و مردان دارد.","Label has advice on pregnancy testing, contraception or fertility for females and males.","Infertility Males Based on findings from studies in rats, linezolid may reversibly impair fertility in male patients [ see Nonclinical Toxicology (13.1) ].",[207],{"source":33,"section":208},"8.3",{"kind":210,"refs":211,"id":151},"ANDA",[212],{"source":33,"section":213},"SPL approval \u002F marketing category",1792115186289]