[{"data":1,"prerenderedAt":279},["ShallowReactive",2],{"drug-leuprolide":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":24,"regimens":63,"contraindications":127,"warnings":137,"renal":145,"monitoring":146,"interactions":147,"review":148,"examples":151,"atc":166,"iran":168,"links":212,"populations":231,"usApproval":274},"leuprolide",1,{"fa":7,"en":8},"لوپرولید","Leuprolide","antineoplastic-immunomodulating",{"fa":11,"en":12},"آگونیست GnRH","GnRH agonist",[14],{"name":15,"market":16},"Lupron Depot","US",[18,19,20,21,22,23],"lupron","لوپرون","لوپرولین","leuprorelin","لوپرورلین","eligard",[25,39,47,55],{"id":26,"form":27,"route":28,"label":29,"concentration":30,"markets":34,"refs":35},"dep-7-5","powder-for-injection","im","7.5 mg depot kit (1-month)",{"amount":31,"unit":32,"perUnit":33},7.5,"mg","vial",[16],[36],{"source":37,"section":38},"fda-lupron-depot","3",{"id":40,"form":27,"route":28,"label":41,"concentration":42,"markets":44,"refs":45},"dep-22-5","22.5 mg depot kit (3-month)",{"amount":43,"unit":32,"perUnit":33},22.5,[16],[46],{"source":37,"section":38},{"id":48,"form":27,"route":28,"label":49,"concentration":50,"markets":52,"refs":53},"dep-30","30 mg depot kit (4-month)",{"amount":51,"unit":32,"perUnit":33},30,[16],[54],{"source":37,"section":38},{"id":56,"form":27,"route":28,"label":57,"concentration":58,"markets":60,"refs":61},"dep-45","45 mg depot kit (6-month)",{"amount":59,"unit":32,"perUnit":33},45,[16],[62],{"source":37,"section":38},[64,88,101,114],{"id":65,"disease":66,"label":67,"population":70,"type":74,"unit":32,"dose":75,"refs":76,"durationDays":79,"allowedFormulations":80,"notes":81},"m1","prostate-cancer",{"fa":68,"en":69},"سرطان پیشرفته پروستات — ۷٫۵ mg عضلانی هر ۴ هفته","Advanced prostate cancer — 7.5 mg IM every 4 weeks",{"minAge":71},{"value":72,"unit":73},18,"year","fixed",{"perDose":31,"dosesPerDay":5},[77],{"source":37,"section":78},"2.1",{"min":5,"max":5},[26],[82],{"text":83,"refs":86},{"fa":84,"en":85},"فقط توسط کادر درمان؛ دوزهای کسری یا ترکیب فرآورده‌های دپو مجاز نیست (رهش متفاوت).","Healthcare provider only; no fractional doses or combinations of depot products (different release).",[87],{"source":37,"section":78},{"id":89,"disease":66,"label":90,"population":93,"type":74,"unit":32,"dose":95,"refs":96,"durationDays":99,"allowedFormulations":100},"m3",{"fa":91,"en":92},"سرطان پیشرفته پروستات — ۲۲٫۵ mg عضلانی هر ۱۲ هفته","Advanced prostate cancer — 22.5 mg IM every 12 weeks",{"minAge":94},{"value":72,"unit":73},{"perDose":43,"dosesPerDay":5},[97],{"source":37,"section":98},"2.2",{"min":5,"max":5},[40],{"id":102,"disease":66,"label":103,"population":106,"type":74,"unit":32,"dose":108,"refs":109,"durationDays":112,"allowedFormulations":113},"m4",{"fa":104,"en":105},"سرطان پیشرفته پروستات — ۳۰ mg عضلانی هر ۱۶ هفته","Advanced prostate cancer — 30 mg IM every 16 weeks",{"minAge":107},{"value":72,"unit":73},{"perDose":51,"dosesPerDay":5},[110],{"source":37,"section":111},"2.3",{"min":5,"max":5},[48],{"id":115,"disease":66,"label":116,"population":119,"type":74,"unit":32,"dose":121,"refs":122,"durationDays":125,"allowedFormulations":126},"m6",{"fa":117,"en":118},"سرطان پیشرفته پروستات — ۴۵ mg عضلانی هر ۲۴ هفته","Advanced prostate cancer — 45 mg IM every 24 weeks",{"minAge":120},{"value":72,"unit":73},{"perDose":59,"dosesPerDay":5},[123],{"source":37,"section":124},"2.4",{"min":5,"max":5},[56],[128],{"id":129,"severity":130,"text":131,"refs":134},"hyper","block",{"fa":132,"en":133},"حساسیت به GnRH، آگونیست‌های GnRH یا اجزای فرآورده.","Hypersensitivity to GnRH, GnRH agonists or any excipient.",[135],{"source":37,"section":136},"4",[138],{"text":139,"refs":142},{"fa":140,"en":141},"افزایش گذرای تستوسترون و شعله‌ور شدن تومور (درد استخوان، فشار نخاع، انسداد ادراری) در هفته‌های اول؛ سندرم متابولیک و دیابت؛ بیماری قلبی‌عروقی؛ طولانی شدن QT؛ تشنج.","Transient testosterone surge and tumour flare (bone pain, spinal cord compression, urinary obstruction) in the first weeks; metabolic syndrome and diabetes; cardiovascular disease; QT prolongation; convulsions.",[143],{"source":37,"section":144},"5",[],[],[],{"status":149,"reviewer":150,"date":150},"unverified",null,[152,157,160,163],{"regimen":65,"formulation":26,"input":153,"expect":156},{"ageYears":154,"weightKg":155},70,75,{"perDose":31},{"regimen":89,"formulation":40,"input":158,"expect":159},{"ageYears":154,"weightKg":155},{"perDose":43},{"regimen":102,"formulation":48,"input":161,"expect":162},{"ageYears":154,"weightKg":155},{"perDose":51},{"regimen":115,"formulation":56,"input":164,"expect":165},{"ageYears":154,"weightKg":155},{"perDose":59},[167],"L02AE02",{"status":169,"forms":170,"refs":207},"registered",[171,175,179,183,187,191,195,199,203],{"code":172,"en":173,"fa":174},"16637","LEUPROLIDE 7.5MG AMP","آمپول لوپرولاید ۷٫۵ میلی‌گرم",{"code":176,"en":177,"fa":178},"18097","LEUPRORELIN ACETATE 2.8 MG  VIAL","ویال لوپرورلین استات ۲٫۸ میلی‌گرم",{"code":180,"en":181,"fa":182},"18438","LEUPRORELIN ACETATE 3.75MG SYRINGE","سرنگ لوپرورلین استات ۳٫۷۵ میلی‌گرم",{"code":184,"en":185,"fa":186},"01570","LEUPRORELIN ACETATE 3.75MG VIAL","ویال لوپرورلین استات ۳٫۷۵ میلی‌گرم",{"code":188,"en":189,"fa":190},"17435","LEUPRORELIN ACETATE 7.5MG INJ","فرآورده تزریقی لوپرورلین استات ۷٫۵ میلی‌گرم",{"code":192,"en":193,"fa":194},"00000","LEUPRORELIN ACETATE 22.5MG  VIAL","ویال لوپرورلین استات ۲۲٫۵ میلی‌گرم",{"code":196,"en":197,"fa":198},"22422","LEUPRORELIN ACETATE INJECTION, POWDER, FOR SUSPENSION, EXTENDED RELEASE PARENTERAL 7.5 mg","پودر تزریقی لوپرورلین استات ۷٫۵ میلی‌گرم",{"code":200,"en":201,"fa":202},"50346","LEUPRORELIN ACETATE INJECTION, POWDER, FOR SUSPENSION, EXTENDED RELEASE PARENTERAL 22.5 mg","پودر تزریقی لوپرورلین استات ۲۲٫۵ میلی‌گرم",{"code":204,"en":205,"fa":206},"50541","LEUPRORELIN ACETATE INJECTION, POWDER, FOR SUSPENSION, EXTENDED RELEASE PARENTERAL 45 mg","پودر تزریقی لوپرورلین استات ۴۵ میلی‌گرم",[208],{"source":209,"section":210,"url":211},"darooyab-generic","G-2704\u002FLeuprorelin","https:\u002F\u002Fwww.darooyab.ir\u002FG-2704\u002FLeuprorelin",[213,217,221,225,228],{"kind":214,"url":215,"label":216},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=020517","NDA020517",{"kind":218,"url":219,"label":220},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=cbc8f94e-7330-4465-05ad-16d64493a5dd","FDA Lupron Depot",{"kind":222,"url":223,"label":224},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa685040.html","Leuprolide Injection",{"kind":226,"url":227,"label":167},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=L02AE02",{"kind":229,"url":211,"label":230},"darooyab","Leuprorelin",{"pregnancy":232,"lactation":241,"pediatric":250,"geriatric":258,"reproductive":266},{"level":233,"text":234,"quote":237,"refs":238},"avoid",{"fa":235,"en":236},"برچسب: می‌تواند به جنین آسیب بزند. در بارداری خطرناک است.","Label: can cause fetal harm. Dangerous in pregnancy.","Risk Summary Based on findings in animal studies and mechanism of action, LUPRON DEPOT may cause fetal harm when administered to a pregnant woman [see Clinical Pharmacology ( 12.1 )] .",[239],{"source":37,"section":240},"8.1",{"level":242,"text":243,"quote":246,"refs":247},"caution",{"fa":244,"en":245},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","The safety and efficacy of LUPRON DEPOT have not been established in females.",[248],{"source":37,"section":249},"8.2",{"level":242,"text":251,"quote":254,"refs":255},{"fa":252,"en":253},"برچسب برای کودکان شرط، محدودیت سنی یا نکته دارد؛ جمله برچسب در زیر آمده است.","The label has conditions, age limits or notes for children; the label sentence is quoted below.","See LUPRON DEPOT-PED ® (leuprolide acetate for depot suspension) labeling for the safety and effectiveness in children with central precocious puberty.",[256],{"source":37,"section":257},"8.4",{"level":242,"text":259,"quote":262,"refs":263},{"fa":260,"en":261},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","In the clinical trials for LUPRON DEPOT in prostate cancer 80% of the subjects studied were at least 65 years of age.",[264],{"source":37,"section":265},"8.5",{"level":242,"text":267,"quote":270,"refs":271},{"fa":268,"en":269},"برچسب نکته‌ای درباره بارداری، پیشگیری یا باروری زنان و مردان دارد.","Label has advice on pregnancy testing, contraception or fertility for females and males.","Infertility Males Based on findings in animals and mechanism of action, LUPRON DEPOT may impair fertility in males of reproductive potential [see Nonclinical Toxicology ( 13.1 )] .",[272],{"source":37,"section":273},"8.3",{"kind":275,"refs":276,"id":216},"NDA",[277],{"source":37,"section":278},"SPL approval \u002F marketing category",1792191551812]