[{"data":1,"prerenderedAt":163},["ShallowReactive",2],{"drug-letrozole":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":20,"regimens":35,"contraindications":59,"warnings":69,"renal":70,"monitoring":71,"interactions":72,"review":73,"examples":76,"atc":82,"iran":84,"links":96,"populations":113,"usApproval":158},"letrozole",1,{"fa":7,"en":8},"لتروزول","Letrozole","antineoplastic-immunomodulating",{"fa":11,"en":12},"مهارکننده آروماتاز","Aromatase inhibitor",[14],{"name":15,"market":16},"Femara","US",[18,19,7],"femara","فمارا",[21],{"id":22,"form":23,"route":24,"label":25,"concentration":26,"markets":30,"refs":31},"tab-2-5","tablet","oral","2.5 mg tablet",{"amount":27,"unit":28,"perUnit":23,"scored":29},2.5,"mg",false,[16],[32],{"source":33,"section":34},"fda-letrozole","3",[36],{"id":37,"disease":38,"label":39,"population":42,"type":46,"unit":28,"dose":47,"refs":48,"notes":51},"bc","breast-cancer",{"fa":40,"en":41},"سرطان پستان پس از یائسگی — ۲٫۵ mg روزانه","Postmenopausal breast cancer — 2.5 mg once daily",{"minAge":43},{"value":44,"unit":45},18,"year","fixed",{"perDose":27,"dosesPerDay":5},[49],{"source":33,"section":50},"2.1",[52],{"text":53,"refs":56},{"fa":54,"en":55},"سیروز یا نارسایی شدید کبد: ۲٫۵ mg یک روز در میان. کاربرد در ناباروری در برچسب FDA نیست.","Cirrhosis or severe hepatic impairment: 2.5 mg every other day. Use for infertility is not in the FDA label.",[57],{"source":33,"section":58},"2.5",[60],{"id":61,"severity":62,"text":63,"refs":66},"ci","block",{"fa":64,"en":65},"بارداری (آسیب جنین)؛ حساسیت.","Pregnancy (fetal harm); hypersensitivity.",[67],{"source":33,"section":68},"4",[],[],[],[],{"status":74,"reviewer":75,"date":75},"unverified",null,[77],{"regimen":37,"formulation":22,"input":78,"expect":81},{"ageYears":79,"weightKg":80},60,70,{"perDose":27,"tabletsPerDoseRounded":5},[83],"L02BG04",{"status":85,"forms":86,"refs":91},"registered",[87],{"code":88,"en":89,"fa":90},"01922","LETROZOLE 2.5MG TAB","قرص لتروزول ۲٫۵ میلی‌گرم",[92],{"source":93,"section":94,"url":95},"darooyab-generic","G-1019\u002FLetrozole","https:\u002F\u002Fwww.darooyab.ir\u002FG-1019\u002FLetrozole",[97,101,105,108,111],{"kind":98,"url":99,"label":100},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=200161","ANDA200161",{"kind":102,"url":103,"label":104},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=63e54b62-a30d-4a56-9215-75e7a0b0bf02","FDA Letrozole",{"kind":106,"url":107,"label":8},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa698004.html",{"kind":109,"url":110,"label":83},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=L02BG04",{"kind":112,"url":95,"label":8},"darooyab",{"pregnancy":114,"lactation":122,"pediatric":131,"geriatric":140,"reproductive":149},{"level":115,"text":116,"quote":119,"refs":120},"contraindicated",{"fa":117,"en":118},"برچسب: در بارداری منع مصرف دارد.","Label: contraindicated in pregnancy.","Pregnancy: Letrozole can cause fetal harm [see Use in Specific Populations (8.1) ] .",[121],{"source":33,"section":68},{"level":123,"text":124,"quote":127,"refs":128},"avoid",{"fa":125,"en":126},"برچسب: شیردهی توصیه نمی‌شود یا باید بین دارو و شیردهی یکی انتخاب شود.","Label: breastfeeding not recommended, or choose between the drug and breastfeeding.","Because of the potential for serious adverse reactions in breastfed infants from letrozole, advise lactating women not to breastfeed while taking letrozole and for at least 3 weeks after the last dose.",[129],{"source":33,"section":130},"8.2",{"level":132,"text":133,"quote":136,"refs":137},"not-established",{"fa":134,"en":135},"برچسب: ایمنی و اثربخشی در کودکان ثابت نشده است.","Label: safety and effectiveness in children have not been established.","The safety and effectiveness in pediatric patients have not been established.",[138],{"source":33,"section":139},"8.4",{"level":141,"text":142,"quote":145,"refs":146},"ok",{"fa":143,"en":144},"برچسب: در سالمندان تفاوت یا تنظیم دوز خاصی ذکر نشده.","Label: no specific difference or dose adjustment stated for older adults.","However, in comparison to tamoxifen, no overall differences with regards to the safety and efficacy profiles were observed between elderly patients and younger patients.",[147],{"source":33,"section":148},"8.5",{"level":150,"text":151,"quote":154,"refs":155},"caution",{"fa":152,"en":153},"برچسب نکته‌ای درباره بارداری، پیشگیری یا باروری زنان و مردان دارد.","Label has advice on pregnancy testing, contraception or fertility for females and males.","Contraception Females Based on animal studies, letrozole tablets can cause fetal harm when administered to a pregnant woman [see Use in Specific Populations (8.1) ] .",[156],{"source":33,"section":157},"8.3",{"kind":159,"refs":160,"id":100},"ANDA",[161],{"source":33,"section":162},"SPL approval \u002F marketing category",1792092037455]