[{"data":1,"prerenderedAt":122},["ShallowReactive",2],{"drug-lamotrigine":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":21,"regimens":61,"contraindications":95,"warnings":114,"renal":115,"monitoring":116,"interactions":117,"review":118,"examples":121},"lamotrigine",1,{"fa":7,"en":8},"لاموتریژین","Lamotrigine","neurology",{"fa":11,"en":12},"ضدتشنج \u002F تثبیت‌کننده خلق","Anticonvulsant \u002F mood stabiliser",[14],{"name":15,"market":16},"Lamictal","US",[18,19,7,20],"lamictal","لامیکتال","لاموتریجین",[22,37,45,53],{"id":23,"form":24,"route":25,"label":26,"concentration":27,"markets":32,"refs":33},"tab-25","odt","oral","25 mg tablet",{"amount":28,"unit":29,"perUnit":30,"scored":31},25,"mg","tablet",false,[16],[34],{"source":35,"section":36},"fda-lamotrigine","3",{"id":38,"form":24,"route":25,"label":39,"concentration":40,"markets":42,"refs":43},"tab-50","50 mg tablet",{"amount":41,"unit":29,"perUnit":30,"scored":31},50,[16],[44],{"source":35,"section":36},{"id":46,"form":24,"route":25,"label":47,"concentration":48,"markets":50,"refs":51},"tab-100","100 mg tablet",{"amount":49,"unit":29,"perUnit":30,"scored":31},100,[16],[52],{"source":35,"section":36},{"id":54,"form":24,"route":25,"label":55,"concentration":56,"markets":58,"refs":59},"tab-200","200 mg tablet",{"amount":57,"unit":29,"perUnit":30,"scored":31},200,[16],[60],{"source":35,"section":36},[62,82],{"id":63,"disease":64,"label":65,"population":68,"type":72,"unit":29,"dose":73,"refs":77},"bipolar","bipolar-maintenance",{"fa":66,"en":67},"دوقطبی (نگهدارنده) — بزرگسال","Bipolar maintenance — adults",{"minAge":69},{"value":70,"unit":71},18,"year","notCalculated",{"reason":74},{"fa":75,"en":76},"دوز هدف ۲۰۰ mg\u002Fday؛ با والپروات ۱۰۰ mg\u002Fday؛ با کاربامازپین\u002Fفنی‌توئین\u002Fفنوباربیتال بدون والپروات ۴۰۰ mg\u002Fday. افزایش دوز باید دقیقاً طبق جداول برچسب (بسته به والپروات یا القاکننده‌های آنزیمی) باشد تا خطر راش کشنده کم شود؛ Doz این جداول را محاسبه نمی‌کند.","Target 200 mg\u002Fday; with valproate 100 mg\u002Fday; with carbamazepine\u002Fphenytoin\u002Fphenobarbital without valproate 400 mg\u002Fday. Escalation must follow the label tables exactly (depends on valproate or enzyme inducers) to reduce the risk of fatal rash; Doz does not calculate these tables.",[78,80],{"source":35,"section":79},"2.4",{"source":35,"section":81},"2.4, Table 5",{"id":83,"disease":83,"label":84,"population":87,"type":72,"unit":29,"dose":88,"refs":92},"epilepsy",{"fa":85,"en":86},"صرع — بزرگسال و کودک","Epilepsy — adults and children",{},{"reason":89},{"fa":90,"en":91},"افزایش دوز باید دقیقاً طبق جداول برچسب (بسته به والپروات یا القاکننده‌های آنزیمی) باشد تا خطر راش کشنده کم شود؛ Doz این جداول را محاسبه نمی‌کند.","Escalation must follow the label tables exactly (depends on valproate or enzyme inducers) to reduce the risk of fatal rash; Doz does not calculate these tables.",[93],{"source":35,"section":94},"2.2, Tables 1–2",[96,105],{"id":97,"severity":98,"text":99,"refs":102},"ci","block",{"fa":100,"en":101},"حساسیت (راش، آنژیوادم، کهیر، زخم مخاطی) به لاموتریژین.","Hypersensitivity (rash, angioedema, urticaria, mucosal ulceration) to lamotrigine.",[103],{"source":35,"section":104},"4",{"id":106,"severity":107,"text":108,"refs":111},"rash","warn",{"fa":109,"en":110},"هشدار جعبه‌ای: راش جدی (SJS\u002FTEN)؛ در کودکان ۰٫۳ تا ۰٫۸٪. خطر با والپروات، دوز اولیه بالا یا افزایش سریع بیشتر است.","Boxed warning: serious rash (SJS\u002FTEN); 0.3–0.8% in children. Higher risk with valproate, high starting dose or rapid escalation.",[112],{"source":35,"section":113},"Boxed Warning",[],[],[],[],{"status":119,"reviewer":120,"date":120},"unverified",null,[],1792078536883]