[{"data":1,"prerenderedAt":155},["ShallowReactive",2],{"drug-isoflurane":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":21,"regimens":34,"contraindications":55,"warnings":65,"renal":73,"monitoring":74,"interactions":75,"review":76,"examples":79,"atc":80,"iran":82,"usApproval":102,"links":108,"populations":121},"isoflurane",1,{"fa":7,"en":8},"ایزوفلوران","Isoflurane","nervous-system",{"fa":11,"en":12},"هوشبر استنشاقی هالوژنه","Halogenated inhalational anaesthetic",[14],{"name":15,"market":16},"Forane","US",[18,19,20,7],"forane","terrell","فوران",[22],{"id":23,"form":24,"route":25,"label":26,"concentration":27,"markets":29,"refs":30},"liq","solution","inhaled","Volatile liquid for vaporizer (100%)",{"amount":5,"unit":28,"perUnit":28},"application",[16],[31],{"source":32,"section":33},"fda-terrell","3",[35],{"id":36,"disease":37,"label":38,"population":41,"type":42,"unit":43,"dose":44,"refs":48},"ga","general-anesthesia",{"fa":39,"en":40},"القا و نگهداری بیهوشی عمومی — غلظت دمی ۱٫۵ تا ۳٪ برای القا (۷ تا ۱۰ دقیقه)؛ نگهداری بر اساس MAC سن","Induction and maintenance of general anaesthesia — inspired 1.5–3% for induction (7–10 min); maintenance by age-specific MAC",{},"notCalculated","mg",{"reason":45},{"fa":46,"en":47},"دوز درصد غلظت دمی است، نه وزنی. القا ممکن است سرفه، حبس نفس و لارنگواسپاسم بدهد. فقط با ویپوریزر ویژه ایزوفلوران.","Dosed as inspired %, not by weight. Induction may cause coughing, breath-holding and laryngospasm. Only with an isoflurane-specific vaporizer.",[49,51,53],{"source":32,"section":50},"2.3",{"source":32,"section":52},"2.4",{"source":32,"section":54},"2.1",[56],{"id":57,"severity":58,"text":59,"refs":62},"ci","block",{"fa":60,"en":61},"استعداد ژنتیکی (شناخته یا مشکوک) هیپرترمی بدخیم؛ حساسیت به این دارو یا سایر هوشبرهای هالوژنه؛ موارد منع بیهوشی عمومی؛ سابقه هپاتیت ناشی از هوشبر هالوژنه.","Known or suspected genetic susceptibility to malignant hyperthermia; sensitivity to this or other halogenated anaesthetics; patients in whom general anaesthesia is contraindicated; prior hepatitis from a halogenated anaesthetic.",[63],{"source":32,"section":64},"4",[66],{"text":67,"refs":70},{"fa":68,"en":69},"هیپرترمی بدخیم؛ هیپرکالمی حین عمل (به‌ویژه میوپاتی‌ها)؛ طولانی شدن QT؛ آسیب کبد؛ نوروتوکسیسیتی احتمالی در کودک زیر ۳ سال با بیهوشی طولانی.","Malignant hyperthermia; perioperative hyperkalaemia (especially myopathies); QT prolongation; hepatic injury; possible neurotoxicity in children under 3 with prolonged anaesthesia.",[71],{"source":32,"section":72},"5",[],[],[],{"status":77,"reviewer":78,"date":78},"unverified",null,[],[81],"N01AB06",{"status":83,"forms":84,"refs":97},"registered",[85,89,93],{"code":86,"en":87,"fa":88},"01943","ISOFLURANE 100ML SOL FOR INHALATION","محلول ایزوفلوران ۱۰۰ میلی‌لیتر",{"code":90,"en":91,"fa":92},"01557","ISOFLURANE 100ML SPRAY","اسپری ایزوفلوران ۱۰۰ میلی‌لیتر",{"code":94,"en":95,"fa":96},"53048","ISOFLURANE INHALANT RESPIRATORY 100 % 250 mL","ایزوفلوران اینهالانت ۱۰۰ درصد ۲۵۰ میلی‌لیتر",[98],{"source":99,"section":100,"url":101},"darooyab-generic","G-2670\u002FIsoflurane","https:\u002F\u002Fwww.darooyab.ir\u002FG-2670\u002FIsoflurane",{"kind":103,"refs":104,"id":107},"ANDA",[105],{"source":32,"section":106},"SPL approval \u002F marketing category","ANDA074416",[109,112,116,119],{"kind":110,"url":111,"label":107},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=074416",{"kind":113,"url":114,"label":115},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=dfb26527-c5ab-44d0-9236-24b1600e0db4","FDA Terrell (isoflurane)",{"kind":117,"url":118,"label":81},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=N01AB06",{"kind":120,"url":101,"label":8},"darooyab",{"pregnancy":122,"lactation":131,"pediatric":139,"geriatric":147},{"level":123,"text":124,"quote":127,"refs":128},"caution",{"fa":125,"en":126},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","Risk Summary There are no adequate and well-controlled studies in pregnant women.",[129],{"source":32,"section":130},"8.1",{"level":123,"text":132,"quote":135,"refs":136},{"fa":133,"en":134},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","Due to insufficient information regarding the excretion of isoflurane in human milk, the potential risks and benefits for each specific patient should be carefully considered before isoflurane is administered to nursing women.",[137],{"source":32,"section":138},"8.2",{"level":123,"text":140,"quote":143,"refs":144},{"fa":141,"en":142},"برچسب برای کودکان شرط، محدودیت سنی یا نکته دارد؛ جمله برچسب در زیر آمده است.","The label has conditions, age limits or notes for children; the label sentence is quoted below.","During the induction of anesthesia, saliva flow and tracheobronchial secretion can increase and can be the cause of larynogospasm, particularly in children.",[145],{"source":32,"section":146},"8.4",{"level":123,"text":148,"quote":151,"refs":152},{"fa":149,"en":150},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","The minimum alveolar concentration (MAC) of isoflurane decreases with increasing patient age.",[153],{"source":32,"section":154},"8.5",1792444404961]