[{"data":1,"prerenderedAt":143},["ShallowReactive",2],{"drug-insulin-glulisine":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":21,"regimens":35,"contraindications":54,"warnings":64,"renal":72,"monitoring":73,"interactions":74,"review":75,"examples":78,"atc":79,"iran":81,"usApproval":88,"links":94,"populations":109},"insulin-glulisine",1,{"fa":7,"en":8},"انسولین گلولیزین","Insulin glulisine","alimentary-metabolism",{"fa":11,"en":12},"انسولین سریع‌الاثر","Rapid-acting insulin",[14],{"name":15,"market":16},"Apidra","US",[18,19,20],"apidra","آپیدرا","گلولیزین",[22],{"id":23,"form":24,"route":25,"label":26,"concentration":27,"markets":30,"refs":31},"u100","injection","sc","100 units\u002FmL vial or SoloStar pen",{"amount":28,"unit":29,"perVolumeMl":5},100,"unit",[16],[32],{"source":33,"section":34},"fda-apidra","3",[36],{"id":37,"disease":38,"label":39,"population":42,"type":43,"unit":44,"dose":45,"refs":49},"dm","type-1-diabetes",{"fa":40,"en":41},"دیابت — دوز فردی همراه غذا","Diabetes — individualised mealtime dose",{},"notCalculated","mg",{"reason":46},{"fa":47,"en":48},"برچسب: دوز بر اساس نیاز متابولیک، پایش قند و هدف درمان فردی شود؛ زیرجلدی ظرف ۱۵ دقیقه قبل یا ۲۰ دقیقه پس از شروع غذا؛ معمولاً همراه انسولین پایه.","Label: individualise by metabolic needs, glucose monitoring and goals; SC within 15 min before or within 20 min after starting a meal; usually with a basal insulin.",[50,52],{"source":33,"section":51},"2.3",{"source":33,"section":53},"2",[55],{"id":56,"severity":57,"text":58,"refs":61},"ci","block",{"fa":59,"en":60},"هنگام هیپوگلیسمی؛ حساسیت به انسولین گلولیزین.","During hypoglycaemia; hypersensitivity to insulin glulisine.",[62],{"source":33,"section":63},"4",[65],{"text":66,"refs":69},{"fa":67,"en":68},"هیپوگلیسمی؛ هیپوکالمی؛ قلم مشترک ممنوع.","Hypoglycaemia; hypokalaemia; never share pens.",[70],{"source":33,"section":71},"5",[],[],[],{"status":76,"reviewer":77,"date":77},"unverified",null,[],[80],"A10AB06",{"status":82,"refs":83},"not-found",[84],{"source":85,"section":86,"url":87},"darooyab-generic","search","https:\u002F\u002Fwww.darooyab.ir\u002FSearch?q=Insulin%20glulisine",{"kind":89,"refs":90,"id":93},"BLA",[91],{"source":33,"section":92},"SPL approval \u002F marketing category","BLA021629",[95,98,102,106],{"kind":96,"url":97,"label":93},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=021629",{"kind":99,"url":100,"label":101},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=e7af6a7a-8046-4fb4-9979-4ec4230b23aa","FDA Apidra",{"kind":103,"url":104,"label":105},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa607033.html","Insulin Glulisine (rDNA origin) Injection",{"kind":107,"url":108,"label":80},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=A10AB06",{"pregnancy":110,"lactation":119,"pediatric":127,"geriatric":135},{"level":111,"text":112,"quote":115,"refs":116},"caution",{"fa":113,"en":114},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","Risk Summary Available pharmacovigilance data have not established an association with insulin glulisine use during pregnancy and major birth defects, miscarriage or adverse maternal or fetal outcomes.",[117],{"source":33,"section":118},"8.1",{"level":111,"text":120,"quote":123,"refs":124},{"fa":121,"en":122},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","Risk Summary Available data from published literature suggest that human insulin products, including APIDRA, are transferred into human milk.",[125],{"source":33,"section":126},"8.2",{"level":111,"text":128,"quote":131,"refs":132},{"fa":129,"en":130},"برچسب برای کودکان شرط، محدودیت سنی یا نکته دارد؛ جمله برچسب در زیر آمده است.","The label has conditions, age limits or notes for children; the label sentence is quoted below.","The safety and effectiveness of APIDRA to improve glycemic control have been established in pediatric patients.",[133],{"source":33,"section":134},"8.4",{"level":111,"text":136,"quote":139,"refs":140},{"fa":137,"en":138},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","Nevertheless, caution should be exercised when APIDRA is administered to geriatric patients.",[141],{"source":33,"section":142},"8.5",1792156182618]