[{"data":1,"prerenderedAt":172},["ShallowReactive",2],{"drug-insulin-detemir":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":21,"regimens":35,"contraindications":76,"warnings":86,"renal":94,"monitoring":95,"interactions":96,"review":97,"examples":100,"atc":107,"iran":109,"usApproval":116,"links":122,"populations":137},"insulin-detemir",1,{"fa":7,"en":8},"انسولین دتمیر","Insulin detemir","alimentary-metabolism",{"fa":11,"en":12},"انسولین پایه طولانی‌اثر","Long-acting basal insulin",[14],{"name":15,"market":16},"Levemir","US",[18,19,20],"levemir","لومیر","دتمیر",[22],{"id":23,"form":24,"route":25,"label":26,"concentration":27,"markets":30,"refs":31},"u100","injection","sc","100 units\u002FmL FlexPen or vial",{"amount":28,"unit":29,"perVolumeMl":5},100,"unit",[16],[32],{"source":33,"section":34},"fda-levemir","3",[36,61],{"id":37,"disease":38,"label":39,"population":42,"type":46,"unit":29,"dose":47,"refs":49,"notes":52},"t2","type-2-diabetes",{"fa":40,"en":41},"دیابت نوع ۲ — ۱۰ واحد (یا ۰٫۱ تا ۰٫۲ واحد\u002Fkg) یک بار عصر","Type 2 diabetes — 10 units (or 0.1–0.2 units\u002Fkg) once daily in the evening",{"minAge":43},{"value":44,"unit":45},18,"year","fixed",{"perDose":48,"dosesPerDay":5},10,[50],{"source":33,"section":51},"2.3",[53],{"text":54,"refs":57},{"fa":55,"en":56},"یک بار با شام یا هنگام خواب، یا تقسیم دو بار در روز. تنظیم بر اساس قند.","Once with the evening meal or at bedtime, or split twice daily. Titrate by glucose.",[58,60],{"source":33,"section":59},"2.2",{"source":33,"section":51},{"id":62,"disease":63,"label":64,"population":67,"type":68,"unit":69,"dose":70,"refs":74},"t1","type-1-diabetes",{"fa":65,"en":66},"دیابت نوع ۱ — یک‌سوم تا نیمی از کل انسولین روزانه","Type 1 diabetes — one-third to one-half of total daily insulin",{},"notCalculated","mg",{"reason":71},{"fa":72,"en":73},"کل انسولین روزانه به‌طور کلی ۰٫۲ تا ۰٫۴ واحد\u002Fkg؛ یک‌سوم تا نیمی دتمیر و بقیه انسولین کوتاه‌اثر با غذا.","Total daily insulin generally 0.2–0.4 units\u002Fkg; one-third to one-half as detemir, the rest as short-acting with meals.",[75],{"source":33,"section":51},[77],{"id":78,"severity":79,"text":80,"refs":83},"ci","block",{"fa":81,"en":82},"هنگام هیپوگلیسمی؛ حساسیت به انسولین دتمیر.","During hypoglycaemia; hypersensitivity to insulin detemir.",[84],{"source":33,"section":85},"4",[87],{"text":88,"refs":91},{"fa":89,"en":90},"هیپوگلیسمی؛ هیپوکالمی؛ قلم مشترک ممنوع.","Hypoglycaemia; hypokalaemia; never share pens.",[92],{"source":33,"section":93},"5",[],[],[],{"status":98,"reviewer":99,"date":99},"unverified",null,[101],{"regimen":37,"formulation":23,"input":102,"expect":105},{"ageYears":103,"weightKg":104},55,90,{"perDose":48,"mlPerDose":106},0.1,[108],"A10AE05",{"status":110,"refs":111},"not-found",[112],{"source":113,"section":114,"url":115},"darooyab-generic","search","https:\u002F\u002Fwww.darooyab.ir\u002FSearch?q=Insulin%20detemir",{"kind":117,"refs":118,"id":121},"BLA",[119],{"source":33,"section":120},"SPL approval \u002F marketing category","BLA021536",[123,126,130,134],{"kind":124,"url":125,"label":121},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=021536",{"kind":127,"url":128,"label":129},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=82192527-99aa-4b53-8ce9-9173668d309c","FDA Levemir",{"kind":131,"url":132,"label":133},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa606012.html","Insulin Detemir (rDNA Origin) Injection",{"kind":135,"url":136,"label":108},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=A10AE05",{"pregnancy":138,"lactation":147,"pediatric":155,"geriatric":163},{"level":139,"text":140,"quote":143,"refs":144},"caution",{"fa":141,"en":142},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","Risk Summary Available data from published studies and postmarketing case reports with LEVEMIR use in pregnant women have not identified a drug-associated risk of major birth defects, miscarriage, or adverse maternal or fetal outcomes.",[145],{"source":33,"section":146},"8.1",{"level":139,"text":148,"quote":151,"refs":152},{"fa":149,"en":150},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","Risk Summary Available data from published literature demonstrate that exogenous human insulin products, including biosynthetic insulins such as insulin detemir, are transferred into human milk.",[153],{"source":33,"section":154},"8.2",{"level":139,"text":156,"quote":159,"refs":160},{"fa":157,"en":158},"برچسب برای کودکان شرط، محدودیت سنی یا نکته دارد؛ جمله برچسب در زیر آمده است.","The label has conditions, age limits or notes for children; the label sentence is quoted below.","The safety and effectiveness of LEVEMIR to improve glycemic control in pediatric patients with diabetes mellitus have been established.",[161],{"source":33,"section":162},"8.4",{"level":164,"text":165,"quote":168,"refs":169},"ok",{"fa":166,"en":167},"برچسب: در سالمندان تفاوت یا تنظیم دوز خاصی ذکر نشده.","Label: no specific difference or dose adjustment stated for older adults.","No overall differences in safety or effectiveness were observed between these patients and younger patients, but small sample sizes limits conclusions.",[170],{"source":33,"section":171},"8.5",1792156182529]