[{"data":1,"prerenderedAt":217},["ShallowReactive",2],{"drug-indomethacin":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":12,"synonyms":16,"formulations":19,"regimens":42,"contraindications":70,"warnings":80,"renal":88,"monitoring":89,"interactions":90,"review":91,"examples":94,"atc":103,"iran":105,"usApproval":149,"links":155,"populations":174},"indomethacin",1,{"fa":7,"en":8},"ایندومتاسین","Indomethacin","musculoskeletal",{"fa":11,"en":11},"NSAID",[13],{"name":14,"market":15},"Indocin","US",[17,7,18],"indocin","اندومتاسین",[20,34],{"id":21,"form":22,"route":23,"label":24,"concentration":25,"markets":29,"refs":30},"cap-25","capsule","oral","25 mg capsule",{"amount":26,"unit":27,"perUnit":22,"scored":28},25,"mg",false,[15],[31],{"source":32,"section":33},"fda-indomethacin","3",{"id":35,"form":22,"route":23,"label":36,"concentration":37,"markets":39,"refs":40},"cap-50","50 mg capsule",{"amount":38,"unit":27,"perUnit":22,"scored":28},50,[15],[41],{"source":32,"section":33},[43,59],{"id":44,"disease":45,"label":46,"population":49,"type":53,"unit":27,"dose":54,"refs":56},"arthritis","rheumatoid-arthritis",{"fa":47,"en":48},"آرتریت روماتوئید، استئوآرتریت، اسپوندیلیت — ۲۵ mg دو یا سه بار در روز","RA, OA, ankylosing spondylitis — 25 mg two or three times daily",{"minAge":50},{"value":51,"unit":52},18,"year","fixed",{"perDose":26,"dosesPerDay":55},3,[57],{"source":32,"section":58},"2.2",{"id":60,"disease":60,"label":61,"population":64,"type":53,"unit":27,"dose":66,"refs":67},"gout",{"fa":62,"en":63},"حمله حاد نقرس — ۵۰ mg سه بار در روز","Acute gouty arthritis — 50 mg three times daily",{"minAge":65},{"value":51,"unit":52},{"perDose":38,"dosesPerDay":55},[68],{"source":32,"section":69},"2.4",[71],{"id":72,"severity":73,"text":74,"refs":77},"nsaid","block",{"fa":75,"en":76},"حساسیت؛ سابقه آسم، کهیر یا واکنش آلرژیک با آسپرین یا NSAID؛ درد حین جراحی CABG.","Hypersensitivity; history of asthma, urticaria or allergic reaction to aspirin or NSAIDs; perioperative pain in CABG.",[78],{"source":32,"section":79},"4",[81],{"text":82,"refs":85},{"fa":83,"en":84},"هشدار جعبه‌ای: خطر حوادث قلبی‌عروقی ترومبوتیک و خونریزی، زخم و سوراخ شدن دستگاه گوارش.","Boxed warning: risk of serious thrombotic cardiovascular events and GI bleeding, ulceration and perforation.",[86],{"source":32,"section":87},"Boxed Warning",[],[],[],{"status":92,"reviewer":93,"date":93},"unverified",null,[95,99],{"regimen":44,"formulation":21,"input":96,"expect":98},{"ageYears":38,"weightKg":97},70,{"perDose":26,"tabletsPerDoseRounded":5},{"regimen":60,"formulation":35,"input":100,"expect":102},{"ageYears":38,"weightKg":101},80,{"perDose":38,"tabletsPerDoseRounded":5},[104],"M01AB01",{"status":106,"forms":107,"refs":144},"registered",[108,112,116,120,124,128,132,136,140],{"code":109,"en":110,"fa":111},"01541","INDOMETHACIN 1% OPH DROP","قطره چشمی ایندومتاسین ۱ درصد",{"code":113,"en":114,"fa":115},"00668","INDOMETHACIN 100MG SUPP","شیاف ایندومتاسین ۱۰۰ میلی‌گرم",{"code":117,"en":118,"fa":119},"06467","INDOMETHACIN 100ML SUSP","سوسپانسیون ایندومتاسین ۱۰۰ میلی‌لیتر",{"code":121,"en":122,"fa":123},"00669","INDOMETHACIN 25MG CAP","کپسول ایندومتاسین ۲۵ میلی‌گرم",{"code":125,"en":126,"fa":127},"00670","INDOMETHACIN 50MG SUPP","شیاف ایندومتاسین ۵۰ میلی‌گرم",{"code":129,"en":130,"fa":131},"19235","INDOMETHACIN 50MG\u002F2ML INJ","فرآورده تزریقی ایندومتاسین ۵۰ میلی‌گرم \u002F ۲ میلی‌لیتر",{"code":133,"en":134,"fa":135},"01542","INDOMETHACIN AMP","آمپول ایندومتاسین",{"code":137,"en":138,"fa":139},"00671","INDOMETHACIN SR 75MG TAB","قرص آهسته‌رهش ایندومتاسین ۷۵ میلی‌گرم",{"code":141,"en":142,"fa":143},"02139","INDOMETHACIN SR 80MG TAB","قرص آهسته‌رهش ایندومتاسین ۸۰ میلی‌گرم",[145],{"source":146,"section":147,"url":148},"darooyab-generic","G-104\u002FIndomethacin","https:\u002F\u002Fwww.darooyab.ir\u002FG-104\u002FIndomethacin",{"kind":150,"refs":151,"id":154},"ANDA",[152],{"source":32,"section":153},"SPL approval \u002F marketing category","ANDA091276",[156,159,163,166,169,172],{"kind":157,"url":158,"label":154},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=091276",{"kind":160,"url":161,"label":162},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=f7ed39e2-5431-4e47-935c-c7441d058f94","FDA Indomethacin",{"kind":164,"url":165,"label":8},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa681027.html",{"kind":164,"url":167,"label":168},"https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa621040.html","Indomethacin Rectal",{"kind":170,"url":171,"label":104},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=M01AB01",{"kind":173,"url":148,"label":8},"darooyab",{"pregnancy":175,"lactation":184,"pediatric":193,"geriatric":202,"reproductive":209},{"level":176,"text":177,"quote":180,"refs":181},"avoid",{"fa":178,"en":179},"برچسب: می‌تواند به جنین آسیب بزند. در بارداری خطرناک است.","Label: can cause fetal harm. Dangerous in pregnancy.","Clinical Considerations Fetal\u002FNeonatal Adverse Reactions Premature Closure of Fetal Ductus Arteriosus: Avoid use of NSAIDs in women at about 30 weeks gestation and later in pregnancy, because NSAIDs, including indomethacin capsules, can cause premature closure of the fetal ductus arteriosus ( see Data ).",[182],{"source":32,"section":183},"8.1",{"level":185,"text":186,"quote":189,"refs":190},"caution",{"fa":187,"en":188},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","Risk Summary Based on available published clinical data, indomethacin may be present in human milk.",[191],{"source":32,"section":192},"8.2",{"level":194,"text":195,"quote":198,"refs":199},"not-established",{"fa":196,"en":197},"برچسب: ایمنی و اثربخشی در کودکان ثابت نشده است.","Label: safety and effectiveness in children have not been established.","Safety and effectiveness in pediatric patients 14 years of age and younger has not been established.",[200],{"source":32,"section":201},"8.4",{"level":185,"text":203,"quote":206,"refs":207},{"fa":204,"en":205},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","Elderly patients and patients with a prior history of peptic ulcer disease and\u002For GI bleeding are at greater risk for serious GI events ( 5.2 ) Cardiovascular Thrombotic Events • Nonsteroidal anti-inflammatory drugs (NSAIDs) cause an increased risk of serious cardiovascular thrombotic events, including myocardial …",[208],{"source":32,"section":87},{"level":185,"text":210,"quote":213,"refs":214},{"fa":211,"en":212},"برچسب نکته‌ای درباره بارداری، پیشگیری یا باروری زنان و مردان دارد.","Label has advice on pregnancy testing, contraception or fertility for females and males.","Infertility Females Based on the mechanism of action, the use of prostaglandin-mediated NSAIDs, including indomethacin capsules, may delay or prevent rupture of ovarian follicles, which has been associated with reversible infertility in some women.",[215],{"source":32,"section":216},"8.3",1792111457132]