[{"data":1,"prerenderedAt":210},["ShallowReactive",2],{"drug-imipenem-cilastatin":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":22,"regimens":37,"contraindications":93,"warnings":103,"renal":111,"monitoring":121,"interactions":122,"review":130,"examples":133,"atc":145,"iran":147,"links":154,"populations":170,"usApproval":205},"imipenem-cilastatin",1,{"fa":7,"en":8},"ایمی‌پنم-سیلاستاتین","Imipenem-cilastatin","anti-infectives",{"fa":11,"en":12},"کارباپنم","Carbapenem",[14],{"name":15,"market":16},"Primaxin","US",[18,19,20,21],"primaxin","tienam","تینام","ایمی پنم",[23],{"id":24,"form":25,"route":26,"label":27,"concentration":28,"markets":32,"refs":33},"vial-500","powder-for-injection","iv","500 mg imipenem + 500 mg cilastatin vial (dose = imipenem)",{"amount":29,"unit":30,"perUnit":31},500,"mg","vial",[16],[34],{"source":35,"section":36},"fda-imipenem","3",[38,65],{"id":39,"disease":40,"label":41,"population":44,"type":48,"unit":30,"dose":49,"refs":51,"limits":54,"notes":58},"adult","sepsis",{"fa":42,"en":43},"عفونت‌های شدید بزرگسال (ClCr ≥۹۰) — ۵۰۰ mg هر ۶ ساعت (یا ۱ g هر ۸ ساعت)","Serious infections, adult (CrCl ≥90) — 500 mg every 6 h (or 1 g every 8 h)",{"minAge":45},{"value":46,"unit":47},18,"year","fixed",{"perDose":29,"dosesPerDay":50},4,[52],{"source":35,"section":53},"2.1",{"maxPerDay":55,"refs":56},4000,[57],{"source":35,"section":53},[59],{"text":60,"refs":63},{"fa":61,"en":62},"برای ارگانیسم با حساسیت کمتر: ۱ g هر ۶ ساعت. دوز بر حسب ایمی‌پنم.","Less susceptible organisms: 1 g every 6 h. Dose refers to imipenem.",[64],{"source":35,"section":53},{"id":66,"disease":40,"label":67,"population":70,"type":75,"unit":30,"dose":76,"refs":80,"limits":83,"notes":86},"child",{"fa":68,"en":69},"کودک ۳ ماه به بالا (غیر CNS) — ۱۵ تا ۲۵ mg\u002Fkg هر ۶ ساعت","Child ≥3 months (non-CNS) — 15–25 mg\u002Fkg every 6 h",{"minAge":71,"maxAge":74},{"value":72,"unit":73},3,"month",{"value":46,"unit":47},"weightBased",{"perKgPerDose":77,"perKgPerDoseMax":78,"intervalHours":79},15,25,6,[81],{"source":35,"section":82},"2.2",{"maxPerDay":55,"refs":84},[85],{"source":35,"section":82},[87],{"text":88,"refs":91},{"fa":89,"en":90},"برای عفونت CNS کودکان توصیه نمی‌شود (خطر تشنج).","Not recommended for pediatric CNS infections (seizure risk).",[92],{"source":35,"section":82},[94],{"id":95,"severity":96,"text":97,"refs":100},"hyper","block",{"fa":98,"en":99},"حساسیت به هر جزء فرآورده.","Hypersensitivity to any component.",[101],{"source":35,"section":102},"4",[104],{"text":105,"refs":108},{"fa":106,"en":107},"واکنش آلرژیک جدی؛ اسهال مرتبط با کلستریدیوم دیفیسیل؛ تشنج (به‌ویژه در نارسایی کلیه).","Serious hypersensitivity; Clostridioides difficile-associated diarrhoea; seizures (especially with renal impairment).",[109],{"source":35,"section":110},"5",[112],{"egfrBelow":113,"severity":114,"text":115,"refs":118},90,"warn",{"fa":116,"en":117},"ClCr زیر ۹۰ طبق جدول برچسب کاهش یابد؛ ClCr زیر ۱۵ فقط با دیالیز.","Reduce per label table when CrCl \u003C90; CrCl \u003C15 only if dialysis is started within 48 h.",[119],{"source":35,"section":120},"2.3",[],[123],{"with":124,"text":125,"refs":128},"valproate",{"fa":126,"en":127},"والپروات: کاهش سطح و خطر تشنج — همزمان توصیه نمی‌شود.","Valproic acid: reduced levels and seizure risk — not recommended.",[129],{"source":35,"section":110},{"status":131,"reviewer":132,"date":132},"unverified",null,[134,139],{"regimen":39,"formulation":24,"input":135,"expect":138},{"ageYears":136,"weightKg":137},50,70,{"perDose":29,"dosesPerDay":50},{"regimen":66,"formulation":24,"input":140,"expect":143},{"ageYears":141,"weightKg":142},5,20,{"perDose":144,"upperPerDose":29},300,[146],"J01DH51",{"status":148,"refs":149},"not-found",[150],{"source":151,"section":152,"url":153},"darooyab-generic","search","https:\u002F\u002Fwww.darooyab.ir\u002FSearch?q=Imipenem-cilastatin",[155,159,163,167],{"kind":156,"url":157,"label":158},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=050587","NDA050587",{"kind":160,"url":161,"label":162},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=f41d8abd-7792-4918-1b93-bd83ea01955e","FDA Primaxin",{"kind":164,"url":165,"label":166},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa686013.html","Imipenem and Cilastatin Injection",{"kind":168,"url":169,"label":146},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=J01DH51",{"pregnancy":171,"lactation":180,"pediatric":188,"geriatric":197},{"level":172,"text":173,"quote":176,"refs":177},"caution",{"fa":174,"en":175},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","Risk Summary Available data from a small number of postmarketing cases with PRIMAXIN use in pregnancy are not sufficient to identify any drug-associated risks for major birth defects, miscarriage, or adverse maternal or fetal outcomes.",[178],{"source":35,"section":179},"8.1",{"level":172,"text":181,"quote":184,"refs":185},{"fa":182,"en":183},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","Risk Summary There are insufficient data on the presence of imipenem\u002Fcilastatin in human milk, and no data on the effects on the breastfed child, or the effects on milk production.",[186],{"source":35,"section":187},"8.2",{"level":189,"text":190,"quote":193,"refs":194},"not-established",{"fa":191,"en":192},"برچسب: ایمنی و اثربخشی در کودکان ثابت نشده است.","Label: safety and effectiveness in children have not been established.","PRIMAXIN is not recommended in pediatric patients with CNS infections because of the risk of seizures.",[195],{"source":35,"section":196},"8.4",{"level":172,"text":198,"quote":201,"refs":202},{"fa":199,"en":200},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","Because elderly patients are more likely to have decreased renal function, care should be taken in dose selection, and it may be useful to monitor renal function.",[203],{"source":35,"section":204},"8.5",{"kind":206,"refs":207,"id":158},"NDA",[208],{"source":35,"section":209},"SPL approval \u002F marketing category",1792115183686]