[{"data":1,"prerenderedAt":196},["ShallowReactive",2],{"drug-hydromorphone":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":19,"regimens":51,"contraindications":79,"warnings":89,"renal":99,"monitoring":108,"interactions":109,"review":110,"examples":113,"atc":119,"iran":121,"links":128,"populations":148,"usApproval":191},"hydromorphone",1,{"fa":7,"en":8},"هیدرومورفون","Hydromorphone","nervous-system",{"fa":11,"en":12},"آگونیست اپیوئیدی","Opioid agonist",[14],{"name":15,"market":16},"Dilaudid","US",[18,7],"dilaudid",[20,34,42],{"id":21,"form":22,"route":23,"label":24,"concentration":25,"markets":29,"refs":30},"tab-2","tablet","oral","2 mg tablet",{"amount":26,"unit":27,"perUnit":22,"scored":28},2,"mg",false,[16],[31],{"source":32,"section":33},"fda-hydromorphone-tab","3",{"id":35,"form":22,"route":23,"label":36,"concentration":37,"markets":39,"refs":40},"tab-4","4 mg tablet",{"amount":38,"unit":27,"perUnit":22,"scored":28},4,[16],[41],{"source":32,"section":33},{"id":43,"form":22,"route":23,"label":44,"concentration":45,"markets":48,"refs":49},"tab-8","8 mg tablet (scored)",{"amount":46,"unit":27,"perUnit":22,"scored":47},8,true,[16],[50],{"source":32,"section":33},[52],{"id":53,"disease":54,"label":55,"population":58,"type":62,"unit":27,"dose":63,"refs":64,"notes":67},"pain","severe-pain",{"fa":56,"en":57},"درد شدید (بیمار بدون مصرف قبلی اپیوئید) — ۲ تا ۴ mg هر ۴ تا ۶ ساعت در صورت نیاز","Severe pain (opioid-naive) — 2–4 mg every 4–6 h as needed",{"minAge":59},{"value":60,"unit":61},18,"year","fixed",{"perDose":26,"perDoseMax":38,"dosesPerDay":38},[65],{"source":32,"section":66},"2.3",[68],{"text":69,"refs":72},{"fa":70,"en":71},"کمترین دوز مؤثر در کوتاه‌ترین مدت. «هر ۴ تا ۶ ساعت در صورت نیاز»؛ عدد دفعات در ماشین‌حساب برای ۶ ساعت است. نارسایی کبد یا کلیه: شروع با یک‌چهارم تا نصف دوز.","Lowest effective dose for the shortest time. “Every 4–6 h as needed”; the calculator shows 6-hourly. Hepatic or renal impairment: start at one-quarter to one-half the dose.",[73,75,77],{"source":32,"section":74},"2.1",{"source":32,"section":76},"2.4",{"source":32,"section":78},"2.5",[80],{"id":81,"severity":82,"text":83,"refs":86},"ci","block",{"fa":84,"en":85},"دپرسیون تنفسی قابل‌توجه؛ آسم حاد یا شدید بدون پایش؛ انسداد گوارشی یا ایلئوس فلجی؛ حساسیت.","Significant respiratory depression; acute or severe asthma without monitoring; GI obstruction or paralytic ileus; hypersensitivity.",[87],{"source":32,"section":88},"4",[90],{"text":91,"refs":94},{"fa":92,"en":93},"هشدار جعبه‌ای: اعتیاد و سوءمصرف، دپرسیون تنفسی کشنده، مصرف تصادفی در کودک، سندرم ترک نوزادی، تداخل با بنزودیازپین‌ها و مهارکننده‌های CYP3A4. نالوکسان در دسترس باشد.","Boxed warning: addiction and misuse, life-threatening respiratory depression, accidental ingestion in children, neonatal opioid withdrawal, interactions with benzodiazepines and CYP3A4 inhibitors. Keep naloxone available.",[95,97],{"source":32,"section":96},"Boxed Warning",{"source":32,"section":98},"2.2",[100],{"egfrBelow":101,"severity":102,"text":103,"refs":106},60,"warn",{"fa":104,"en":105},"شروع با یک‌چهارم تا نصف دوز معمول بسته به شدت نارسایی.","Start at one-quarter to one-half the usual dose depending on the degree of impairment.",[107],{"source":32,"section":78},[],[],{"status":111,"reviewer":112,"date":112},"unverified",null,[114],{"regimen":53,"formulation":21,"input":115,"expect":118},{"ageYears":116,"weightKg":117},50,70,{"perDose":26,"upperPerDose":38},[120],"N02AA03",{"status":122,"refs":123},"not-found",[124],{"source":125,"section":126,"url":127},"darooyab-generic","G-100\u002FHydromorphone","https:\u002F\u002Fwww.darooyab.ir\u002FG-100\u002FHydromorphone",[129,133,137,140,143,146],{"kind":130,"url":131,"label":132},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=076855","ANDA076855",{"kind":134,"url":135,"label":136},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=4c5c1cc8-c42b-46e3-ad68-8e22f57101f2","FDA Hydromorphone tab",{"kind":138,"url":139,"label":8},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa682013.html",{"kind":138,"url":141,"label":142},"https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa601148.html","Hydromorphone Injection",{"kind":144,"url":145,"label":120},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=N02AA03",{"kind":147,"url":127,"label":8},"darooyab",{"pregnancy":149,"lactation":157,"pediatric":166,"geriatric":175,"reproductive":183},{"level":150,"text":151,"quote":154,"refs":155},"avoid",{"fa":152,"en":153},"برچسب: می‌تواند به جنین آسیب بزند. در بارداری خطرناک است.","Label: can cause fetal harm. Dangerous in pregnancy.","Neonatal Opioid Withdrawal Syndrome (NOWS) Advise pregnant women using opioids for an extended period of time of the risk of Neonatal Opioid Withdrawal Syndrome, which may be life-threatening if not recognized and treated.",[156],{"source":32,"section":96},{"level":158,"text":159,"quote":162,"refs":163},"caution",{"fa":160,"en":161},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","Risk Summary Low levels of opioid analgesics have been detected in human milk.",[164],{"source":32,"section":165},"8.2",{"level":167,"text":168,"quote":171,"refs":172},"not-established",{"fa":169,"en":170},"برچسب: ایمنی و اثربخشی در کودکان ثابت نشده. مصرف تصادفی حتی یک دوز در کودک می‌تواند کشنده باشد.","Label: not established in children. Accidental ingestion of even one dose by a child can be fatal.","The safety and effectiveness of hydromorphone hydrochloride tablets in pediatric patients have not been established.",[173],{"source":32,"section":174},"8.4",{"level":158,"text":176,"quote":179,"refs":180},{"fa":177,"en":178},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","In general, use caution when selecting a dosage for an elderly patient, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function and of concomitant disease or other drug therapy.",[181],{"source":32,"section":182},"8.5",{"level":158,"text":184,"quote":187,"refs":188},{"fa":185,"en":186},"برچسب نکته‌ای درباره بارداری، پیشگیری یا باروری زنان و مردان دارد.","Label has advice on pregnancy testing, contraception or fertility for females and males.","Infertility Use of opioids for an extended period of time may cause reduced fertility in females and males of reproductive potential.",[189],{"source":32,"section":190},"8.3",{"kind":192,"refs":193,"id":132},"ANDA",[194],{"source":32,"section":195},"SPL approval \u002F marketing category",1792156181293]