[{"data":1,"prerenderedAt":223},["ShallowReactive",2],{"drug-goserelin":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":20,"regimens":35,"contraindications":99,"warnings":109,"renal":117,"monitoring":118,"interactions":119,"review":120,"examples":123,"atc":139,"iran":141,"usApproval":165,"links":171,"populations":188},"goserelin",1,{"fa":7,"en":8},"گوسرلین","Goserelin","antineoplastic-immunomodulating",{"fa":11,"en":12},"آگونیست GnRH (ایمپلنت)","GnRH agonist (implant)",[14],{"name":15,"market":16},"Zoladex","US",[18,19,7],"zoladex","زولادکس",[21],{"id":22,"form":23,"route":24,"label":25,"concentration":26,"markets":30,"refs":31},"impl-3-6","injection","sc","3.6 mg implant in prefilled syringe",{"amount":27,"unit":28,"perUnit":29},3.6,"mg","application",[16],[32],{"source":33,"section":34},"fda-zoladex","3",[36,62,76],{"id":37,"disease":38,"label":39,"population":42,"type":46,"unit":28,"dose":47,"refs":48,"durationDays":53,"notes":54},"pca","prostate-cancer",{"fa":40,"en":41},"سرطان پروستات — ۳٫۶ mg زیرجلد شکم هر ۲۸ روز","Prostate cancer — 3.6 mg SC into the abdominal wall every 28 days",{"minAge":43},{"value":44,"unit":45},18,"year","fixed",{"perDose":27,"dosesPerDay":5},[49,51],{"source":33,"section":50},"2",{"source":33,"section":52},"2.2",{"min":5,"max":5},[55],{"text":56,"refs":59},{"fa":57,"en":58},"همراه رادیوتراپی و فلوتامید (T2b-T4): ۸ هفته پیش از رادیوتراپی شروع شود.","With radiotherapy and flutamide (T2b–T4): start 8 weeks before radiotherapy.",[60],{"source":33,"section":61},"2.1",{"id":63,"disease":64,"label":65,"population":68,"type":46,"unit":28,"dose":70,"refs":71,"durationDays":75},"bca","breast-cancer",{"fa":66,"en":67},"سرطان پیشرفته پستان — ۳٫۶ mg زیرجلد هر ۲۸ روز","Advanced breast cancer — 3.6 mg SC every 28 days",{"minAge":69},{"value":44,"unit":45},{"perDose":27,"dosesPerDay":5},[72,73],{"source":33,"section":50},{"source":33,"section":74},"2.5",{"min":5,"max":5},{"id":77,"disease":78,"label":79,"population":82,"type":46,"unit":28,"dose":84,"refs":85,"durationDays":89,"notes":90},"endo","endometriosis",{"fa":80,"en":81},"اندومتریوز — ۳٫۶ mg زیرجلد هر ۲۸ روز، ۶ ماه","Endometriosis — 3.6 mg SC every 28 days for 6 months",{"minAge":83},{"value":44,"unit":45},{"perDose":27,"dosesPerDay":5},[86,87],{"source":33,"section":50},{"source":33,"section":88},"2.3",{"min":5,"max":5},[91],{"text":92,"refs":95},{"fa":93,"en":94},"بیش از ۶ ماه و درمان مجدد توصیه نمی‌شود (داده ایمنی نیست). نازک کردن آندومتر پیش از ابلیشن: ۱ یا ۲ دوز با ۴ هفته فاصله.","Not beyond 6 months and no retreatment (no safety data). Endometrial thinning before ablation: 1 or 2 depots 4 weeks apart.",[96,97],{"source":33,"section":88},{"source":33,"section":98},"2.4",[100],{"id":101,"severity":102,"text":103,"refs":106},"ci","block",{"fa":104,"en":105},"حساسیت؛ بارداری مگر برای درمان سرطان پیشرفته پستان.","Hypersensitivity; pregnancy unless used for advanced breast cancer.",[107],{"source":33,"section":108},"4",[110],{"text":111,"refs":114},{"fa":112,"en":113},"پیش از شروع بارداری رد شود و پیشگیری غیرهورمونی؛ شعله‌ور شدن تومور؛ هیپرگلیسمی؛ بیماری قلبی‌عروقی؛ هیپرکلسمی؛ QT؛ آسیب محل تزریق (عروق اپی‌گاستریک)؛ افسردگی.","Exclude pregnancy and use non-hormonal contraception; tumour flare; hyperglycaemia; cardiovascular disease; hypercalcaemia; QT; injection-site injury (epigastric vessels); depression.",[115],{"source":33,"section":116},"5",[],[],[],{"status":121,"reviewer":122,"date":122},"unverified",null,[124,129,134],{"regimen":37,"formulation":22,"input":125,"expect":128},{"ageYears":126,"weightKg":127},70,75,{"perDose":27},{"regimen":63,"formulation":22,"input":130,"expect":133},{"ageYears":131,"weightKg":132},50,65,{"perDose":27},{"regimen":77,"formulation":22,"input":135,"expect":138},{"ageYears":136,"weightKg":137},30,60,{"perDose":27},[140],"L02AE03",{"status":142,"forms":143,"refs":160},"registered",[144,148,152,156],{"code":145,"en":146,"fa":147},"07969","GOSERELIN ACETATE 10.8MG SYRINGE","سرنگ گوسرلین استات ۱۰٫۸ میلی‌گرم",{"code":149,"en":150,"fa":151},"09506","GOSERELIN ACETATE 3.6MG AMP","آمپول گوسرلین استات ۳٫۶ میلی‌گرم",{"code":153,"en":154,"fa":155},"50097","GOSERELIN (AS ACETATE) IMPLANT PARENTERAL 10.8 mg","ایمپلنت گوسرلین (معادل استات) ۱۰٫۸ میلی‌گرم",{"code":157,"en":158,"fa":159},"50096","GOSERELIN (AS ACETATE) IMPLANT PARENTERAL 3.6 mg","ایمپلنت گوسرلین (معادل استات) ۳٫۶ میلی‌گرم",[161],{"source":162,"section":163,"url":164},"darooyab-generic","G-2699\u002FGoserelin","https:\u002F\u002Fwww.darooyab.ir\u002FG-2699\u002FGoserelin",{"kind":166,"refs":167,"id":170},"NDA",[168],{"source":33,"section":169},"SPL approval \u002F marketing category","NDA019726",[172,175,179,183,186],{"kind":173,"url":174,"label":170},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=019726",{"kind":176,"url":177,"label":178},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=294b168b-6e5f-4db9-bf70-d599271458b3","FDA Zoladex 3.6",{"kind":180,"url":181,"label":182},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa601002.html","Goserelin Implant",{"kind":184,"url":185,"label":140},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=L02AE03",{"kind":187,"url":164,"label":8},"darooyab",{"pregnancy":189,"lactation":197,"pediatric":206,"geriatric":215},{"level":190,"text":191,"quote":194,"refs":195},"contraindicated",{"fa":192,"en":193},"برچسب: در بارداری منع مصرف دارد.","Label: contraindicated in pregnancy.","…  agonist analogues or any of the components in ZOLADEX [see Warnings and Precautions ( 5.6 )]. 4.2 Pregnancy ZOLADEX is contraindicated during pregnancy unless ZOLADEX is being used for palliative treatment of advanced breast cancer.",[196],{"source":33,"section":108},{"level":198,"text":199,"quote":202,"refs":203},"caution",{"fa":200,"en":201},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","It is not known if goserelin is excreted in human milk.",[204],{"source":33,"section":205},"8.3",{"level":207,"text":208,"quote":211,"refs":212},"not-established",{"fa":209,"en":210},"برچسب: ایمنی و اثربخشی در کودکان ثابت نشده است.","Label: safety and effectiveness in children have not been established.","Safety and effectiveness in pediatric patients have not been established.",[213],{"source":33,"section":214},"8.4",{"level":198,"text":216,"quote":219,"refs":220},{"fa":217,"en":218},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","There is no need for any dosage adjustment when administering ZOLADEX to male geriatric patients.",[221],{"source":33,"section":222},"8.5",1792191547216]