[{"data":1,"prerenderedAt":208},["ShallowReactive",2],{"drug-galantamine":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":21,"regimens":52,"contraindications":78,"warnings":88,"renal":96,"monitoring":106,"interactions":107,"review":108,"examples":111,"atc":117,"iran":119,"usApproval":159,"links":165,"populations":181},"galantamine",1,{"fa":7,"en":8},"گالانتامین","Galantamine","nervous-system",{"fa":11,"en":12},"مهارکننده کولین‌استراز","Cholinesterase inhibitor",[14],{"name":15,"market":16},"Razadyne","US",[18,19,20,7],"razadyne","reminyl","رمینیل",[22,36,44],{"id":23,"form":24,"route":25,"label":26,"concentration":27,"markets":31,"refs":32},"tab-4","tablet","oral","4 mg tablet",{"amount":28,"unit":29,"perUnit":24,"scored":30},4,"mg",false,[16],[33],{"source":34,"section":35},"fda-galantamine","3",{"id":37,"form":24,"route":25,"label":38,"concentration":39,"markets":41,"refs":42},"tab-8","8 mg tablet",{"amount":40,"unit":29,"perUnit":24,"scored":30},8,[16],[43],{"source":34,"section":35},{"id":45,"form":24,"route":25,"label":46,"concentration":47,"markets":49,"refs":50},"tab-12","12 mg tablet",{"amount":48,"unit":29,"perUnit":24,"scored":30},12,[16],[51],{"source":34,"section":35},[53],{"id":54,"disease":55,"label":56,"population":59,"type":63,"unit":29,"dose":64,"refs":66,"notes":69},"ad","alzheimers",{"fa":57,"en":58},"دمانس خفیف تا متوسط آلزایمر — نگهدارنده ۸ mg دو بار (تا ۱۲ mg دو بار)؛ شروع ۴ mg دو بار","Mild to moderate Alzheimer dementia — maintenance 8 mg twice daily (up to 12 mg twice daily); start 4 mg twice daily",{"minAge":60},{"value":61,"unit":62},18,"year","fixed",{"perDose":40,"perDoseMax":48,"dosesPerDay":65},2,[67],{"source":34,"section":68},"2.2",[70],{"text":71,"refs":74},{"fa":72,"en":73},"شروع ۴ mg دو بار، پس از دست‌کم ۴ هفته ۸ mg دو بار و پس از ۴ هفته دیگر تا ۱۲ mg دو بار. با غذا و مایعات کافی. نارسایی متوسط کبد حداکثر ۱۶ mg\u002Fروز؛ شدید توصیه نمی‌شود.","Start 4 mg twice daily; after ≥4 weeks 8 mg twice daily; after another 4 weeks up to 12 mg twice daily. With meals and adequate fluids. Moderate hepatic impairment max 16 mg\u002Fday; severe not recommended.",[75,76],{"source":34,"section":68},{"source":34,"section":77},"2.3",[79],{"id":80,"severity":81,"text":82,"refs":85},"hyper","block",{"fa":83,"en":84},"حساسیت به گالانتامین.","Hypersensitivity to galantamine.",[86],{"source":34,"section":87},"4",[89],{"text":90,"refs":93},{"fa":91,"en":92},"واکنش پوستی شدید (SJS)؛ برادیکاردی و بلوک قلبی؛ خونریزی گوارشی؛ انسداد ادراری؛ تشنج؛ تشدید آسم\u002FCOPD؛ تشدید شل‌کننده‌های عضلانی سوکسینیل‌کولینی در بیهوشی.","Serious skin reactions (SJS); bradycardia and heart block; GI bleeding; urinary outflow obstruction; seizures; asthma\u002FCOPD; exaggerates succinylcholine-type relaxation in anaesthesia.",[94],{"source":34,"section":95},"5",[97],{"egfrBelow":98,"severity":99,"text":100,"refs":103},60,"warn",{"fa":101,"en":102},"ClCr ۹ تا ۵۹: حداکثر ۱۶ mg\u002Fروز؛ زیر ۹ توصیه نمی‌شود.","CrCl 9–59: max 16 mg\u002Fday; below 9 not recommended.",[104],{"source":34,"section":105},"2.4",[],[],{"status":109,"reviewer":110,"date":110},"unverified",null,[112],{"regimen":54,"formulation":23,"input":113,"expect":116},{"ageYears":114,"weightKg":115},75,65,{"perDose":40,"tabletsPerDoseRounded":65,"upperPerDose":48},[118],"N06DA04",{"status":120,"forms":121,"refs":154},"registered",[122,126,130,134,138,142,146,150],{"code":123,"en":124,"fa":125},"21701","GALANTAMINE 12MG CAP","کپسول گالانتامین ۱۲ میلی‌گرم",{"code":127,"en":128,"fa":129},"04956","GALANTAMINE 12MG TAB","قرص گالانتامین ۱۲ میلی‌گرم",{"code":131,"en":132,"fa":133},"16777","GALANTAMINE 16MG ER CAP","کپسول آهسته‌رهش گالانتامین ۱۶ میلی‌گرم",{"code":135,"en":136,"fa":137},"16778","GALANTAMINE 24MG ER CAP","کپسول آهسته‌رهش گالانتامین ۲۴ میلی‌گرم",{"code":139,"en":140,"fa":141},"04954","GALANTAMINE 4MG TAB","قرص گالانتامین ۴ میلی‌گرم",{"code":143,"en":144,"fa":145},"16776","GALANTAMINE 8MG ER CAP","کپسول آهسته‌رهش گالانتامین ۸ میلی‌گرم",{"code":147,"en":148,"fa":149},"04955","GALANTAMINE 8MG TAB","قرص گالانتامین ۸ میلی‌گرم",{"code":151,"en":152,"fa":153},"51328","GALANTAMINE (AS HYDROBROMIDE) SOLUTION ORAL 4 mg\u002F1mL","محلول خوراکی گالانتامین (معادل هیدروبروماید) ۴ میلی‌گرم \u002F ۱ میلی‌لیتر",[155],{"source":156,"section":157,"url":158},"darooyab-generic","G-3046\u002FGalantamine","https:\u002F\u002Fwww.darooyab.ir\u002FG-3046\u002FGalantamine",{"kind":160,"refs":161,"id":164},"ANDA",[162],{"source":34,"section":163},"SPL approval \u002F marketing category","ANDA077604",[166,169,173,176,179],{"kind":167,"url":168,"label":164},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=077604",{"kind":170,"url":171,"label":172},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=10497273-d907-0514-e063-6294a90a1362","FDA Galantamine",{"kind":174,"url":175,"label":8},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa699058.html",{"kind":177,"url":178,"label":118},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=N06DA04",{"kind":180,"url":158,"label":8},"darooyab",{"pregnancy":182,"pediatric":191,"geriatric":200},{"level":183,"text":184,"quote":187,"refs":188},"caution",{"fa":185,"en":186},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","Risk Summary There are no adequate data on the developmental risk associated with the use of galantamine tablets in pregnant women.",[189],{"source":34,"section":190},"8.1",{"level":192,"text":193,"quote":196,"refs":197},"not-established",{"fa":194,"en":195},"برچسب: ایمنی و اثربخشی در کودکان ثابت نشده است.","Label: safety and effectiveness in children have not been established.","The safety and effectiveness in pediatric patients have not been established.",[198],{"source":34,"section":199},"8.4",{"level":183,"text":201,"quote":204,"refs":205},{"fa":202,"en":203},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","Eight double-blind, placebo-controlled clinical trials and 5 open-label trials in a total of 6519 patients have investigated galantamine tablets in the treatment of mild to moderate dementia of the Alzheimer’s type [see Adverse Reactions (6.1) and Clinical Studies (14) ] .",[206],{"source":34,"section":207},"8.5",1792191546311]