[{"data":1,"prerenderedAt":248},["ShallowReactive",2],{"drug-fluorouracil":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":22,"regimens":36,"contraindications":97,"warnings":98,"renal":113,"monitoring":114,"interactions":115,"review":116,"examples":119,"atc":136,"iran":138,"usApproval":178,"links":184,"populations":204},"fluorouracil",1,{"fa":7,"en":8},"فلوئورویوراسیل","Fluorouracil","antineoplastic-immunomodulating",{"fa":11,"en":12},"آنتی‌متابولیت پیریمیدین","Pyrimidine antimetabolite",[14],{"name":15,"market":16},"Adrucil","US",[18,19,20,21],"5-FU","adrucil","فلورواوراسیل","فلوئورواوراسیل",[23],{"id":24,"form":25,"route":26,"label":27,"concentration":28,"markets":31,"refs":32},"vial-50","injection","iv","50 mg\u002FmL (2.5 g\u002F50 mL pharmacy bulk)",{"amount":29,"unit":30,"perVolumeMl":5},50,"mg",[16],[33],{"source":34,"section":35},"fda-fluorouracil","3",[37,70,84],{"id":38,"disease":39,"label":40,"population":43,"type":47,"unit":30,"dose":48,"refs":50,"durationDays":53,"notes":54},"crc","colorectal-cancer",{"fa":41,"en":42},"سرطان کولورکتال (رژیم انفوزیونی با لکوورین) — بولوس ۴۰۰ mg\u002Fm² روز ۱، سپس ۲۴۰۰ تا ۳۰۰۰ mg\u002Fm² انفوزیون ۴۶ ساعته هر ۲ هفته","Colorectal cancer (infusional with leucovorin) — 400 mg\u002Fm² bolus day 1, then 2400–3000 mg\u002Fm² over 46 h every 2 weeks",{"minAge":44},{"value":45,"unit":46},18,"year","bsa",{"perM2PerDay":49,"dividedDoses":5},400,[51],{"source":34,"section":52},"2.3",{"min":5,"max":5},[55,63],{"text":56,"refs":59},{"fa":57,"en":58},"عدد ماشین‌حساب بولوس است. رژیم بولوس: ۵۰۰ mg\u002Fm² روزهای ۱، ۸، ۱۵، ۲۲، ۲۹، ۳۶ در دوره ۸ هفته‌ای. پیش از شروع ژنوتیپ DPYD.","The calculator gives the bolus. Bolus regimen: 500 mg\u002Fm² on days 1, 8, 15, 22, 29, 36 of 8-week cycles. Test DPYD before starting.",[60,61],{"source":34,"section":52},{"source":34,"section":62},"2.1",{"text":64,"refs":67},{"fa":65,"en":66},"فقط زیر نظر پزشک متخصص شیمی‌درمانی و در مرکز مجهز. عدد ماشین‌حساب = mg\u002Fm² برچسب × سطح بدن (Mosteller)؛ پروتکل، فاصله دوره‌ها، تنظیم بر اساس CBC و عملکرد کلیه\u002Fکبد با تیم انکولوژی.","Only under an oncologist in an equipped centre. Calculator = label mg\u002Fm² × BSA (Mosteller); protocol, cycle interval and adjustment for CBC and renal\u002Fhepatic function rest with the oncology team.",[68],{"source":34,"section":69},"2.2",{"id":71,"disease":72,"label":73,"population":76,"type":47,"unit":30,"dose":78,"refs":80,"durationDays":83},"breast","breast-cancer",{"fa":74,"en":75},"سرطان پستان (رژیم بر پایه سیکلوفسفامید) — ۵۰۰ یا ۶۰۰ mg\u002Fm² روزهای ۱ و ۸ هر ۲۸ روز، ۶ دوره","Breast cancer (cyclophosphamide-based) — 500 or 600 mg\u002Fm² on days 1 and 8 every 28 days for 6 cycles",{"minAge":77},{"value":45,"unit":46},{"perM2PerDay":79,"dividedDoses":5},500,[81],{"source":34,"section":82},"2.4",{"min":5,"max":5},{"id":85,"disease":86,"label":87,"population":90,"type":47,"unit":30,"dose":92,"refs":93,"durationDays":96},"pancreas","pancreatic-cancer",{"fa":88,"en":89},"سرطان پانکراس — بولوس ۴۰۰ mg\u002Fm² روز ۱، سپس ۲۴۰۰ mg\u002Fm² طی ۴۶ ساعت هر ۲ هفته","Pancreatic cancer — 400 mg\u002Fm² bolus day 1, then 2400 mg\u002Fm² over 46 h every 2 weeks",{"minAge":91},{"value":45,"unit":46},{"perM2PerDay":49,"dividedDoses":5},[94],{"source":34,"section":95},"2.6",{"min":5,"max":5},[],[99,106],{"text":100,"refs":103},{"fa":101,"en":102},"هشدار جعبه‌ای: واکنش جدی یا مرگ در کمبود کامل DPD — پیش از شروع ژنوتیپ DPYD.","Boxed warning: serious reactions or death with complete DPD deficiency — test DPYD variants first.",[104],{"source":34,"section":105},"Boxed Warning",{"text":107,"refs":110},{"fa":108,"en":109},"سمیت قلبی؛ انسفالوپاتی هیپرآمونمیک؛ سمیت عصبی؛ اسهال؛ سندرم دست-پا؛ سرکوب مغز استخوان؛ موکوزیت؛ افزایش INR با وارفارین.","Cardiotoxicity; hyperammonaemic encephalopathy; neurotoxicity; diarrhoea; hand-foot syndrome; myelosuppression; mucositis; raised INR with warfarin.",[111],{"source":34,"section":112},"5",[],[],[],{"status":117,"reviewer":118,"date":118},"unverified",null,[120,128,133],{"regimen":38,"formulation":24,"input":121,"expect":125},{"ageYears":122,"weightKg":123,"heightCm":124},55,80,180,{"perDose":126,"mlPerDose":127},800,16,{"regimen":71,"formulation":24,"input":129,"expect":130},{"ageYears":122,"weightKg":123,"heightCm":124},{"perDose":131,"mlPerDose":132},1000,20,{"regimen":85,"formulation":24,"input":134,"expect":135},{"ageYears":122,"weightKg":123,"heightCm":124},{"perDose":126,"mlPerDose":127},[137],"L01BC02",{"status":139,"forms":140,"refs":173},"registered",[141,145,149,153,157,161,165,169],{"code":142,"en":143,"fa":144},"14530","FLUOROURACIL 1G\u002F20ML AMP","آمپول فلورواوراسیل ۱ گرم \u002F ۲۰ میلی‌لیتر",{"code":146,"en":147,"fa":148},"19435","FLUOROURACIL 2500MG\u002F50ML INJ","فرآورده تزریقی فلورواوراسیل ۲۵۰۰ میلی‌گرم \u002F ۵۰ میلی‌لیتر",{"code":150,"en":151,"fa":152},"00550","FLUOROURACIL 250MG\u002F5ML AMP","آمپول فلورواوراسیل ۲۵۰ میلی‌گرم \u002F ۵ میلی‌لیتر",{"code":154,"en":155,"fa":156},"00549","FLUOROURACIL 5% 20GR CREAM","کرم فلورواوراسیل ۵ درصد ۲۰ گرم",{"code":158,"en":159,"fa":160},"12007","FLUOROURACIL 5% OINT","پماد فلورواوراسیل ۵ درصد",{"code":162,"en":163,"fa":164},"14528","FLUOROURACIL 500MG\u002F10ML AMP","آمپول فلورواوراسیل ۵۰۰ میلی‌گرم \u002F ۱۰ میلی‌لیتر",{"code":166,"en":167,"fa":168},"20330","FLUOROURACIL 50MG\u002F5ML AMP","آمپول فلورواوراسیل ۵۰ میلی‌گرم \u002F ۵ میلی‌لیتر",{"code":170,"en":171,"fa":172},"21001","FLUOROURACIL 5G\u002F100ML INJ","فرآورده تزریقی فلورواوراسیل ۵ گرم \u002F ۱۰۰ میلی‌لیتر",[174],{"source":175,"section":176,"url":177},"darooyab-generic","G-1003\u002FFluorouracil","https:\u002F\u002Fwww.darooyab.ir\u002FG-1003\u002FFluorouracil",{"kind":179,"refs":180,"id":183},"ANDA",[181],{"source":34,"section":182},"SPL approval \u002F marketing category","ANDA217295",[185,188,192,196,199,202],{"kind":186,"url":187,"label":183},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=217295",{"kind":189,"url":190,"label":191},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=6b34cbf2-66f9-48a4-b41f-deb84ba8e8c4","FDA Fluorouracil",{"kind":193,"url":194,"label":195},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa682708.html","Fluorouracil Injection",{"kind":193,"url":197,"label":198},"https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa605010.html","Fluorouracil Topical",{"kind":200,"url":201,"label":137},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=L01BC02",{"kind":203,"url":177,"label":8},"darooyab",{"pregnancy":205,"lactation":214,"pediatric":222,"geriatric":231,"reproductive":240},{"level":206,"text":207,"quote":210,"refs":211},"avoid",{"fa":208,"en":209},"برچسب: می‌تواند به جنین آسیب بزند. در بارداری خطرناک است.","Label: can cause fetal harm. Dangerous in pregnancy.","Based on its mechanism of action, Fluorouracil can cause fetal harm when administered to a pregnant woman.",[212],{"source":34,"section":213},"8.1",{"level":206,"text":215,"quote":218,"refs":219},{"fa":216,"en":217},"برچسب: شیردهی توصیه نمی‌شود یا باید بین دارو و شیردهی یکی انتخاب شود.","Label: breastfeeding not recommended, or choose between the drug and breastfeeding.","Because many drugs are present in human milk and because of the potential for serious adverse reactions in nursing infants from Fluorouracil, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.",[220],{"source":34,"section":221},"8.3",{"level":223,"text":224,"quote":227,"refs":228},"not-established",{"fa":225,"en":226},"برچسب: ایمنی و اثربخشی در کودکان ثابت نشده است.","Label: safety and effectiveness in children have not been established.","The safety and effectiveness in pediatric patients have not been established.",[229],{"source":34,"section":230},"8.4",{"level":232,"text":233,"quote":236,"refs":237},"caution",{"fa":234,"en":235},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","Reported clinical experience has not identified differences in safety or effectiveness between the elderly and younger patients.",[238],{"source":34,"section":239},"8.5",{"level":232,"text":241,"quote":244,"refs":245},{"fa":242,"en":243},"برچسب نکته‌ای درباره بارداری، پیشگیری یا باروری زنان و مردان دارد.","Label has advice on pregnancy testing, contraception or fertility for females and males.","Contraception Females Based on its mechanism of action, Fluorouracil can cause fetal harm when administered to a pregnant woman.",[246],{"source":34,"section":247},"8.6",1792444399638]